دورية أكاديمية
أعرض في EDS

Toroidal topology of population activity in grid cells.

التفاصيل البيبلوغرافية
العنوان: Toroidal topology of population activity in grid cells.
المؤلفون: Gardner RJ; Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Trondheim, Norway. richard.gardner@ntnu.no., Hermansen E; Department of Mathematical Sciences, Norwegian University of Science and Technology, Trondheim, Norway., Pachitariu M; HHMI Janelia Research Campus, Ashburn, VA, USA., Burak Y; Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.; Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem, Israel., Baas NA; Department of Mathematical Sciences, Norwegian University of Science and Technology, Trondheim, Norway. nils.baas@ntnu.no., Dunn BA; Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Trondheim, Norway. benjamin.dunn@ntnu.no.; Department of Mathematical Sciences, Norwegian University of Science and Technology, Trondheim, Norway. benjamin.dunn@ntnu.no., Moser MB; Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Trondheim, Norway., Moser EI; Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Trondheim, Norway. edvard.moser@ntnu.no.
المصدر: Nature [Nature] 2022 Feb; Vol. 602 (7895), pp. 123-128. Date of Electronic Publication: 2022 Jan 12.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
أسماء مطبوعة: Publication: Basingstoke : Nature Publishing Group
Original Publication: London, Macmillan Journals ltd.
مواضيع طبية MeSH: Models, Neurological*, Grid Cells/*physiology, Action Potentials ; Animals ; Entorhinal Cortex/anatomy & histology ; Entorhinal Cortex/cytology ; Entorhinal Cortex/physiology ; Grid Cells/classification ; Male ; Rats ; Rats, Long-Evans ; Sleep/physiology ; Space Perception/physiology ; Wakefulness/physiology
مستخلص: The medial entorhinal cortex is part of a neural system for mapping the position of an individual within a physical environment 1 . Grid cells, a key component of this system, fire in a characteristic hexagonal pattern of locations 2 , and are organized in modules 3 that collectively form a population code for the animal's allocentric position 1 . The invariance of the correlation structure of this population code across environments 4,5 and behavioural states 6,7 , independent of specific sensory inputs, has pointed to intrinsic, recurrently connected continuous attractor networks (CANs) as a possible substrate of the grid pattern 1,8-11 . However, whether grid cell networks show continuous attractor dynamics, and how they interface with inputs from the environment, has remained unclear owing to the small samples of cells obtained so far. Here, using simultaneous recordings from many hundreds of grid cells and subsequent topological data analysis, we show that the joint activity of grid cells from an individual module resides on a toroidal manifold, as expected in a two-dimensional CAN. Positions on the torus correspond to positions of the moving animal in the environment. Individual cells are preferentially active at singular positions on the torus. Their positions are maintained between environments and from wakefulness to sleep, as predicted by CAN models for grid cells but not by alternative feedforward models 12 . This demonstration of network dynamics on a toroidal manifold provides a population-level visualization of CAN dynamics in grid cells.
(© 2022. The Author(s).)
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معلومات مُعتمدة: International ERC_ European Research Council
تواريخ الأحداث: Date Created: 20220113 Date Completed: 20220309 Latest Revision: 20221025
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8810387
DOI: 10.1038/s41586-021-04268-7
PMID: 35022611
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-4687
DOI:10.1038/s41586-021-04268-7