دورية أكاديمية
أعرض في EDS

Mitochondrial DNA sequence variation and risk of glioma.

التفاصيل البيبلوغرافية
العنوان: Mitochondrial DNA sequence variation and risk of glioma.
المؤلفون: Samanic CM; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, FL, United States., Teer JK; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, FL, United States., Thompson ZJ; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, FL, United States., Creed JH; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, FL, United States., Fridley BL; Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, FL, United States., Burt Nabors L; Division of NeuroOncology, Department of Neurology, University of Alabama at Birmingham, 510 20th Street South, Faculty Office Tower Suite 1020 Birmingham, Birmingham, AL, United States., Williams SL; UM-CFAR/Sylvester CCC Argentina Consortium for Research and Training in Virally Induced AIDS-Malignancies University of Miami Miller School of Medicine, Miami, FL, United States; Neurology Basic Science Division, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States., Egan KM; Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, FL, United States.
المصدر: Mitochondrion [Mitochondrion] 2022 Mar; Vol. 63, pp. 32-36. Date of Electronic Publication: 2022 Jan 12.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100968751 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8278 (Electronic) Linking ISSN: 15677249 NLM ISO Abbreviation: Mitochondrion Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; New York : Elsevier Science, c2001-
مواضيع طبية MeSH: Brain Neoplasms*/genetics , Glioblastoma*/genetics , Glioma*/genetics, Adult ; Case-Control Studies ; DNA, Mitochondrial/genetics ; Humans
مستخلص: Background: Malignant gliomas are the most common primary adult brain tumors, with a poor prognosis and ill-defined etiology. Mitochondrial DNA (mtDNA) sequence variation has been linked with certain cancers; however, research on glioma is lacking.
Methods: We examined the association of common (minor allele frequency ≥ 5%) germline mtDNA variants and haplogroups with glioma risk in 1,566 glioma cases and 1,017 controls from a US case-control study, and 425 glioma cases and 1,534 matched controls from the UK Biobank cohort (UKB). DNA samples were genotyped using the UK Biobank array that included a set of common and rare mtDNA variants. Risk associations were examined separately for glioblastoma (GBM) and lower grade tumors (non-GBM).
Results: In the US study, haplogroup W was inversely associated with glioma when compared with haplogroup H (OR = 0.43, 95%CI: 0.23-0.79); this association was not demonstrated in the UKB (OR = 1.07, 95%CI: 0.47-2.43). In the UKB, the variant m.3010G > A was significantly associated with GBM (OR = 1.32; 95%CI: 1.01-1.73; p = 0.04), but not non-GBM (1.23; 95%CI: 0.78-1.95; p = 0.38); no similar association was observed in the US study. In the US study, the variant m.14798 T > C, was significantly associated with non-GBM (OR = 0.72; 95%CI: 0.53-0.99), but not GBM (OR = 0.86; 95%CI: 0.66-1.11), whereas in the UKB, a positive association was observed between this variant and GBM (OR = 1.46; 95%CI: 1.06-2.02) but not non-GBM (OR = 0.92; 95%CI: 0.52-1.63). None of these associations were significant after adjustment for multiple testing.
Conclusion: The association of inherited mtDNA variation, including rare and singleton variants, with glioma risk merits further study.
(Copyright © 2022 Elsevier B.V. and Mitochondria Research Society. All rights reserved.)
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معلومات مُعتمدة: P30 CA076292 United States CA NCI NIH HHS; R01 CA116174 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: Glioblastoma; Glioma; Mitochondrial DNA; UK Biobank
المشرفين على المادة: 0 (DNA, Mitochondrial)
تواريخ الأحداث: Date Created: 20220115 Date Completed: 20220428 Latest Revision: 20230302
رمز التحديث: 20230302
مُعرف محوري في PubMed: PMC8885975
DOI: 10.1016/j.mito.2022.01.002
PMID: 35032707
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-8278
DOI:10.1016/j.mito.2022.01.002