دورية أكاديمية
Timing is everything: Circadian rhythms and their role in the control of sleep.
| العنوان: | Timing is everything: Circadian rhythms and their role in the control of sleep. |
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| المؤلفون: | Pandi-Perumal SR; Somnogen Canada Inc, College Street, Toronto, ON, Canada; Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India. Electronic address: Pandiperumal2022@gmail.com., Cardinali DP; Faculty of Medical Sciences, Pontificia Universidad Católica Argentina, 1107 Buenos Aires, Argentina., Zaki NFW; Department of Psychiatry, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Karthikeyan R; Independent Researcher, Avvai Street, Bank Colony, Narayanapuram, Madurai, India., Spence DW; Independent Researcher, Dufferin Street, Toronto, ON, Canada., Reiter RJ; Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA., Brown GM; Centre for Addiction and Mental Health, Molecular Brain Sciences, University of Toronto, 250 College St. Toronto, ON, Canada. |
| المصدر: | Frontiers in neuroendocrinology [Front Neuroendocrinol] 2022 Jul; Vol. 66, pp. 100978. Date of Electronic Publication: 2022 Jan 14. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 7513292 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-6808 (Electronic) Linking ISSN: 00913022 NLM ISO Abbreviation: Front Neuroendocrinol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Orlando, FL : Academic Press Original Publication: New York, Raven Press [etc.] |
| مواضيع طبية MeSH: | Circadian Clocks* , Melatonin*, Circadian Rhythm/physiology ; Humans ; Sleep/physiology ; Suprachiasmatic Nucleus/physiology |
| مستخلص: | Sleep and the circadian clock are intertwined and have persisted throughout history. The suprachiasmatic nucleus (SCN) orchestrates sleep by controlling circadian (Process C) and homeostatic (Process S) activities. As a "hand" on the endogenous circadian clock, melatonin is critical for sleep regulation. Light serves as a cue for sleep/wake control by activating retino-recipient cells in the SCN and subsequently suppressing melatonin. Clock genes are the molecular timekeepers that keep the 24 h cycle in place. Two main sleep and behavioural disorder diagnostic manuals have now officially recognised the importance of these processes for human health and well-being. The body's ability to respond to daily demands with the least amount of effort is maximised by carefully timing and integrating all components of sleep and waking. In the brain, the organization of timing is essential for optimal brain physiology. (Copyright © 2022. Published by Elsevier Inc.) |
| فهرسة مساهمة: | Keywords: Circadian clock; Clock genes; Sleep; Sleep disorder; Sleep medicine |
| المشرفين على المادة: | JL5DK93RCL (Melatonin) |
| تواريخ الأحداث: | Date Created: 20220116 Date Completed: 20220815 Latest Revision: 20221117 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.yfrne.2022.100978 |
| PMID: | 35033557 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1095-6808 |
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| DOI: | 10.1016/j.yfrne.2022.100978 |