Prevalence and Risk Factors Associated with Epilepsy in Six Health Districts of Mali: A Community-Based Cross-Sectional and Nested Case-Control Study.

التفاصيل البيبلوغرافية
العنوان:	Prevalence and Risk Factors Associated with Epilepsy in Six Health Districts of Mali: A Community-Based Cross-Sectional and Nested Case-Control Study.
المؤلفون:	Dolo H; Faculté de Medecine et d'Odonto Stomatologie (FMOS), Université Des Sciences, Des Techniques et des Technologies de Bamako (USTTB), Bamako, Mali.; Département d'Enseignement et de Recherche en Santé Publique et Spécialités, FMOS, USTTB, Bamako, Mali.; Unité Filariose, International Center of Excellence in Research, USTTB, Bamako, Mali., Konipo FDN; Unité Filariose, International Center of Excellence in Research, USTTB, Bamako, Mali., Sow F; Département d'Enseignement et de Recherche en Santé Publique et Spécialités, FMOS, USTTB, Bamako, Mali., Kane F; Faculté de Medecine et d'Odonto Stomatologie (FMOS), Université Des Sciences, Des Techniques et des Technologies de Bamako (USTTB), Bamako, Mali., Sangare M; Faculté de Medecine et d'Odonto Stomatologie (FMOS), Université Des Sciences, Des Techniques et des Technologies de Bamako (USTTB), Bamako, Mali., Daou M; Département de Neurologie, Centre Hospitalo Universitaire, Point G, Bamako, Mali., Sangare M; Faculté de Medecine et d'Odonto Stomatologie (FMOS), Université Des Sciences, Des Techniques et des Technologies de Bamako (USTTB), Bamako, Mali.; Département d'Enseignement et de Recherche en Santé Publique et Spécialités, FMOS, USTTB, Bamako, Mali.; Unité Filariose, International Center of Excellence in Research, USTTB, Bamako, Mali., Sangho O; Département d'Enseignement et de Recherche des Sciences Biologiques et Médicales (DERSBM), Faculté de Pharmacie (FAPH), USTTB, Bamako, Mali., Koné H; Unité Filariose, International Center of Excellence in Research, USTTB, Bamako, Mali., Coulibaly FD; Unité Filariose, International Center of Excellence in Research, USTTB, Bamako, Mali., Coulibaly SY; Unité Filariose, International Center of Excellence in Research, USTTB, Bamako, Mali., Doumbia SS; Unité Filariose, International Center of Excellence in Research, USTTB, Bamako, Mali., Koita A; Département de Neurologie, Centre Hospitalo Universitaire, Gabriel Toure, Bamako, Mali., Sangaré B; Département de Neurologie, Centre Hospitalo Universitaire, Point G, Bamako, Mali., Djimdé S; Département de Neurologie, Centre Hospitalo Universitaire, Point G, Bamako, Mali., Goita S; Département de Neurologie, Centre Hospitalo Universitaire, Gabriel Toure, Bamako, Mali., Bagayoko T; Département de Neurologie, Centre Hospitalo Universitaire, Point G, Bamako, Mali., Dem AB; Département de Neurologie, Centre Hospitalo Universitaire, Point G, Bamako, Mali., Fomba Z; Département de Neurologie, Centre Hospitalo Universitaire, Point G, Bamako, Mali., Gari M; Département de Neurologie, Centre Hospitalo Universitaire, Point G, Bamako, Mali., Kotchene CE; Département de Neurologie, Centre Hospitalo Universitaire, Point G, Bamako, Mali., Orsot KE; Unité Filariose, International Center of Excellence in Research, USTTB, Bamako, Mali., Diarra D; Faculté d'Histoire et de Geography, Université des Sciences Sociales et de Gestion de Bamako (USSGB) Bamako, Bamako, Mali., Colebunders R; Global Health Institute, University of Antwerp, Antwerpen, Belgium., Coulibaly YI; Unité Filariose, International Center of Excellence in Research, USTTB, Bamako, Mali., Sangho H; Faculté de Medecine et d'Odonto Stomatologie (FMOS), Université Des Sciences, Des Techniques et des Technologies de Bamako (USTTB), Bamako, Mali.; Département d'Enseignement et de Recherche en Santé Publique et Spécialités, FMOS, USTTB, Bamako, Mali., Maiga YM; Faculté de Medecine et d'Odonto Stomatologie (FMOS), Université Des Sciences, Des Techniques et des Technologies de Bamako (USTTB), Bamako, Mali.; Département de Neurologie, Centre Hospitalo Universitaire, Point G, Bamako, Mali., Doumbia S; Faculté de Medecine et d'Odonto Stomatologie (FMOS), Université Des Sciences, Des Techniques et des Technologies de Bamako (USTTB), Bamako, Mali.; Département d'Enseignement et de Recherche en Santé Publique et Spécialités, FMOS, USTTB, Bamako, Mali.; University Clinical Research Center (UCRC), University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali.
المصدر:	Neuroepidemiology [Neuroepidemiology] 2022; Vol. 56 (2), pp. 127-137. Date of Electronic Publication: 2022 Jan 19.
نوع المنشور:	Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة:	English
بيانات الدورية:	Publisher: S. Karger Country of Publication: Switzerland NLM ID: 8218700 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0208 (Electronic) Linking ISSN: 02515350 NLM ISO Abbreviation: Neuroepidemiology Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Basel ; New York : S. Karger, [1982-
مواضيع طبية MeSH:	Epilepsy/diagnosis , Malaria, Cerebral/complications , Onchocerciasis/complications , Onchocerciasis/drug therapy , Onchocerciasis/epidemiology , Premature Birth, Case-Control Studies ; Cross-Sectional Studies ; Female ; Humans ; Infant, Newborn ; Mali/epidemiology ; Pregnancy ; Prevalence ; Risk Factors
مستخلص:	Introduction: In resource-limited countries, epilepsy prevalence is underestimated and little is known about its risk factors. Objectives: This study aimed to determine the prevalence and risk factors for epilepsy in six health districts (HDs) in Mali. Methods: A community-based cross-sectional and nested case-control study was conducted in 180 villages with the highest number of suspicious epilepsy cases (SECs) in the six study HDs. The SECs were observed as part of a Phase 1 screening conducted by community health workers. For the nested case-control study, one case was matched with at least one control based on residence and age. A case of epilepsy was a person diagnosed with convulsive epilepsy after clinical assessment by a neurologist. A control was a person diagnosed as normal after neurological assessment by a neurologist. Data were collected on sociodemographic characteristics, familial and medical history of epilepsy, consanguinity, place of delivery, preterm birth, length/type of delivery, and history of meningitis and cerebral malaria. A univariate and multivariate binomial logistic regression model was used to analyse factors associated with epilepsy. Results: A total of 1,506 cases of epilepsy and 2,199 controls were enrolled in six HDs. The mean prevalence of epilepsy was 2‰, with the highest in Kenieba (3‰), a previously meso-endemic-onchocerciasis HD, and the lowest in Kadiolo (1.5‰), a hypo-endemic-onchocerciasis HD. Age (adjusted odds ratio [aOR] = 1.02 [95% confidence intervals [CI] 1.02-1.03]), history of cerebral malaria (aOR = 11.41 [95% CI 8.86-14.85]), history of meningitis (aOR = 1.95 [95% CI 1.16-3.29]), living in the HD of Tominian (aOR = 1.69 [95% CI 1.29-2.22]), delayed delivery (aOR = 3.21 [95% CI 2.07-5.07]), and dystocia (aOR = 3.37 [95% CI 2.03-5.73]) were all significantly associated with epilepsy. Conclusion: The prevalence of epilepsy (3‰) in a previously meso-endemic-onchocerciasis HD was much lower than the prevalence (13.35‰) documented in onchocerciasis endemic areas in 2,000. This decrease epilepsy prevalence in the previously meso-endemic region was induced by onchocerciasis, and the reduction was due to an effective community direct treatment with ivermectin programme. Cerebral malaria and obstetrical complications were the main risk factors for epilepsy and interventions improving malaria prevention/treatment and optimizing prenatal and obstetrical care need to be implemented to reduce incidence. (© 2022 S. Karger AG, Basel.)
معلومات مُعتمدة:	D43 TW008652 United States TW FIC NIH HHS
فهرسة مساهمة:	Keywords: Epidemiology; Epilepsy; Mali; Population-based study
تواريخ الأحداث:	Date Created: 20220119 Date Completed: 20220421 Latest Revision: 20230726
رمز التحديث:	20230726
DOI:	10.1159/000522021
PMID:	35045422
قاعدة البيانات:	MEDLINE

Full Text Finder

الوصف
تدمد:	1423-0208
DOI:	10.1159/000522021