دورية أكاديمية
[A Case of Ramucirumab-Related Small Intestinal Perforation in Gastric Cancer].
| العنوان: | [A Case of Ramucirumab-Related Small Intestinal Perforation in Gastric Cancer]. |
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| المؤلفون: | Murase H; Dept. of Surgery, Nitobe Memorial Nakano General Hospital., Oono R, Yoshida T, Ishihara K, Otomo M, Suzuki Y, Hayashi K, Higuchi K, Yoshinouchi S, Kamiya A, Obata M, Ogawa A, Hayashi M, Park S, Iseki H |
| المصدر: | Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2021 Dec; Vol. 48 (13), pp. 1598-1600. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | Japanese |
| بيانات الدورية: | Publisher: Gan To Kagaku Ryohosha Country of Publication: Japan NLM ID: 7810034 Publication Model: Print Cited Medium: Print ISSN: 0385-0684 (Print) Linking ISSN: 03850684 NLM ISO Abbreviation: Gan To Kagaku Ryoho Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tokyo : Gan To Kagaku Ryohosha Original Publication: Tōkyō, Gan to Kagaku Ryōhōsha [1974?]- |
| مواضيع طبية MeSH: | Intestinal Perforation*/chemically induced , Intestinal Perforation*/surgery , Stomach Neoplasms*/drug therapy , Stomach Neoplasms*/surgery, Antibodies, Monoclonal, Humanized ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Gastrectomy ; Humans ; Male ; Middle Aged ; Ramucirumab |
| مستخلص: | A 54-year-old man underwent laparoscopic distal gastrectomy with D2 lymph node dissection and ante-colic Roux-en-Y reconstruction for gastric cancer. The histopathological diagnosis was pT2N3aM0, pStage ⅢA, HER2 negative. After 8 courses of S-1 plus oxaliplatin as adjuvant chemotherapy, he was diagnosed as peritoneal dissemination and treated with ramucirumab(RAM)plus paclitaxel(PTX). On the 12th day of course 10, he visited to our hospital with abdominal pain. CT showed free air and massive ascites. Emergent surgery was performed under the diagnosis of gastrointestinal perforation. A small intestinal perforation in front of the jejunal limb near gastric-jejunal anastomosis was identified and there was no peritoneal dissemination. We performed partial resection of remnant stomach and jejunal limb by linear stapler and reconstruction by end to side gastric-jejunal anastomosis. Because the gastric and intestinal wall were quite fragile and RAM impaired wound healing as adverse event, we feared about leakage, but he had no major postoperative complications and discharged on the 33th day after surgery. After 24 courses of nivolumab as third-line chemotherapy, the peritoneal dissemination disappeared. He has been alive without recurrence for about 1 year since then. |
| المشرفين على المادة: | 0 (Antibodies, Monoclonal, Humanized) |
| تواريخ الأحداث: | Date Created: 20220120 Date Completed: 20220121 Latest Revision: 20231213 |
| رمز التحديث: | 20240829 |
| PMID: | 35046268 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0385-0684 |
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