دورية أكاديمية
Protective Immunity to Dengue Virus Induced by DNA Vaccines Encoding Nonstructural Proteins in a Lethal Challenge Immunocompetent Mouse Model.
| العنوان: | Protective Immunity to Dengue Virus Induced by DNA Vaccines Encoding Nonstructural Proteins in a Lethal Challenge Immunocompetent Mouse Model. |
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| المؤلفون: | Alves RPDS; Laboratório de Desenvolvimento de Vacinas, Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil., Andreata-Santos R; Laboratório de Desenvolvimento de Vacinas, Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil., de Freitas CL; Laboratório de Interações Neuroimunes, Departamento de Imunologia, Universidade de São Paulo, São Paulo, Brazil., Pereira LR; Laboratório de Desenvolvimento de Vacinas, Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil., Fabris-Maeda DLN; Laboratório de Desenvolvimento de Vacinas, Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil., Rodrigues-Jesus MJ; Laboratório de Desenvolvimento de Vacinas, Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil., Pereira SS; Laboratório de Desenvolvimento de Vacinas, Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil., Carvalho AAVB; Laboratório de Desenvolvimento de Vacinas, Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil., Sales NS; Laboratório de Desenvolvimento de Vacinas, Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil., Peron JPS; Laboratório de Interações Neuroimunes, Departamento de Imunologia, Universidade de São Paulo, São Paulo, Brazil., Amorim JH; Laboratório de Microbiologia, Centro das Ciências Biológicas e da Saúde, Universidade Federal Do Oeste da Bahia, Barreiras, Brazil., Ferreira LCS; Laboratório de Desenvolvimento de Vacinas, Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil. |
| المصدر: | Frontiers in medical technology [Front Med Technol] 2020 Oct 30; Vol. 2, pp. 558984. Date of Electronic Publication: 2020 Oct 30 (Print Publication: 2020). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Country of Publication: Switzerland NLM ID: 101772626 Publication Model: eCollection Cited Medium: Internet ISSN: 2673-3129 (Electronic) Linking ISSN: 26733129 NLM ISO Abbreviation: Front Med Technol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne, Switzerland : Frontiers, [2019]- |
| مستخلص: | Dengue virus represents the main arbovirus affecting humans, but there are no effective drugs or available worldwide licensed vaccine formulations capable of conferring full protection against the infection. Experimental studies and results generated after the release of the licensed anti-DENV vaccine demonstrated that induction of high-titer neutralizing antibodies does not represent the sole protection correlate and that, indeed, T cell-based immune responses plays a relevant role in the establishment of an immune protective state. In this context, this study aimed to further demonstrate protective features of immune responses elicited in immunocompetent C57BL/6 mice immunized with three plasmids encoding DENV2 nonstructural proteins (NS1, NS3, and NS5), which were subsequently challenged with a DENV2 strain naturally capable of inducing lethal encephalitis in immunocompetent mouse strains. The animals were immunized intramuscularly with the DNA vaccine mix and complete protection was observed among vaccinated mice. Vaccine induced protection correlated with the cytokine profiles expressed by spleen cells and brain-infiltrating mononuclear cells. The results confirm the pivotal role of cellular immune responses targeting nonstructural DENV proteins and validate the experimental model based on a DENV2 strain capable of infecting and killing immunocompetent mice as a tool for the evaluation of protective immunity induced by anti-DENV vaccines. (Copyright © 2020 Alves, Andreata-Santos, de Freitas, Pereira, Fabris-Maeda, Rodrigues-Jesus, Pereira, Carvalho, Sales, Peron, Amorim and Ferreira.) |
| التعليقات: | Erratum in: Front Med Technol. 2020 Nov 27;2:626114. (PMID: 35051257) |
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| فهرسة مساهمة: | Keywords: DNA vaccines; IFN-γ; dengue; mouse model; nonstructural proteins |
| تواريخ الأحداث: | Date Created: 20220120 Latest Revision: 20220125 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8757693 |
| DOI: | 10.3389/fmedt.2020.558984 |
| PMID: | 35047876 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2673-3129 |
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| DOI: | 10.3389/fmedt.2020.558984 |