دورية أكاديمية
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Bacillimidazoles A-F, Imidazolium-Containing Compounds Isolated from a Marine Bacillus .

التفاصيل البيبلوغرافية
العنوان: Bacillimidazoles A-F, Imidazolium-Containing Compounds Isolated from a Marine Bacillus .
المؤلفون: Yan JX; Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Ave, Madison, WI 53705, USA., Wu Q; Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Ave, Madison, WI 53705, USA., Helfrich EJN; Harvard Medical School, Harvard University, 240 Longwood Ave, Boston, MA 02115, USA., Chevrette MG; Department of Bacteriology, University of Wisconsin-Madison, 1550 Linden Ave, Madison, WI 53706, USA., Braun DR; Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Ave, Madison, WI 53705, USA., Heyman H; Bruker Daltonics, Bruker Scientific LLC., 40 Manning Rd, Billerica, MA 01821, USA., Ananiev GE; The Small Molecule Screening Facility (SMSF), University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53792, USA., Rajski SR; Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Ave, Madison, WI 53705, USA., Currie CR; Department of Bacteriology, University of Wisconsin-Madison, 1550 Linden Ave, Madison, WI 53706, USA., Clardy J; Harvard Medical School, Harvard University, 240 Longwood Ave, Boston, MA 02115, USA., Bugni TS; Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Ave, Madison, WI 53705, USA.; The Small Molecule Screening Facility (SMSF), University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53792, USA.
المصدر: Marine drugs [Mar Drugs] 2022 Jan 01; Vol. 20 (1). Date of Electronic Publication: 2022 Jan 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2003]-
مواضيع طبية MeSH: Bacillus* , Porifera*, Anti-Bacterial Agents/*pharmacology, Animals ; Anti-Bacterial Agents/chemistry ; Aquatic Organisms ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Microbial Sensitivity Tests
مستخلص: Chemical investigations of a marine sponge-associated Bacillus revealed six new imidazolium-containing compounds, bacillimidazoles A-F ( 1 - 6 ). Previous reports of related imidazolium-containing natural products are rare. Initially unveiled by timsTOF (trapped ion mobility spectrometry) MS data, extensive HRMS and 1D and 2D NMR analyses enabled the structural elucidation of 1 - 6 . In addition, a plausible biosynthetic pathway to bacillimidazoles is proposed based on isotopic labeling experiments and invokes the highly reactive glycolytic adduct 2,3-butanedione. Combined, the results of structure elucidation efforts, isotopic labeling studies and bioinformatics suggest that 1 - 6 result from a fascinating intersection of primary and secondary metabolic pathways in Bacillus sp. WMMC1349. Antimicrobial assays revealed that, of 1 - 6 , only compound six displayed discernible antibacterial activity, despite the close structural similarities shared by all six natural products.
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معلومات مُعتمدة: multiple funds through School of Pharmacy & the Graduate School University of Wisconsin-Madison; OIA-9977484 National Science Foundation; unknown United States Department of Agriculture; U19 AI109673 United States AI NIAID NIH HHS; RR02781 National Institute of Health; BIR-9214394 National Science Foundation; U19AI141720 United States NH NIH HHS; U19AI109673 National Institute of Health; Postdoctoral Mobility Fellowship Switzerland SNSF_ Swiss National Science Foundation; P41GM103399 National Institute of Health; U19 AI142720 United States AI NIAID NIH HHS; R01AT009874 National Institute of Health; RR08438 National Institute of Health; DMB-8415048 National Science Foundation
فهرسة مساهمة: Keywords: antibacterial; biosynthetic gene cluster; heterocycles; imidazolium; isotopic enrichment; marine-derived Bacillus
المشرفين على المادة: 0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20220120 Date Completed: 20220316 Latest Revision: 20230110
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8779896
DOI: 10.3390/md20010043
PMID: 35049898
قاعدة البيانات: MEDLINE
الوصف
تدمد:1660-3397
DOI:10.3390/md20010043