دورية أكاديمية
أعرض في EDS

Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity.

التفاصيل البيبلوغرافية
العنوان: Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity.
المؤلفون: Koupenova M; Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Chan Medical School, Worcester (M.K.)., Livada AC; Aab Cardiovascular Research Institute (A.C.L., C.N.M.), University of Rochester Medical Center, NY.; Department of Pathology and Laboratory Medicine (A.C.L., C.N.M.), University of Rochester Medical Center, NY., Morrell CN; Aab Cardiovascular Research Institute (A.C.L., C.N.M.), University of Rochester Medical Center, NY.; Department of Medicine (C.N.M.), University of Rochester Medical Center, NY.; Department of Pathology and Laboratory Medicine (A.C.L., C.N.M.), University of Rochester Medical Center, NY.; Department of Microbiology and Immunology (C.N.M.), University of Rochester Medical Center, NY.
المصدر: Circulation research [Circ Res] 2022 Jan 21; Vol. 130 (2), pp. 288-308. Date of Electronic Publication: 2022 Jan 20.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE
أسماء مطبوعة: Publication: Baltimore, MD : Lippincott Williams & Wilkins
Original Publication: Baltimore, Md. Grune & Stratton.
مواضيع طبية MeSH: Adaptive Immunity* , Immunity, Innate*, Blood Platelets/*immunology , Megakaryocytes/*immunology, Animals ; Humans
مستخلص: Classically, platelets have been described as the cellular blood component that mediates hemostasis and thrombosis. This important platelet function has received significant research attention for >150 years. The immune cell functions of platelets are much less appreciated. Platelets interact with and activate cells of all branches of immunity in response to pathogen exposures and infection, as well as in response to sterile tissue injury. In this review, we focus on innate immune mechanisms of platelet activation, platelet interactions with innate immune cells, as well as the intersection of platelets and adaptive immunity. The immune potential of platelets is dependent in part on their megakaryocyte precursor providing them with the molecular composition to be first responders and immune sentinels in initiating and orchestrating coordinated pathogen immune responses. There is emerging evidence that extramedullary megakaryocytes may be immune differentiated compared with bone marrow megakaryocytes, but the physiological relevance of immunophenotypic differences are just beginning to be explored. These concepts are also discussed in this review. The immune functions of the megakaryocyte/platelet lineage have likely evolved to coordinate the need to repair a vascular breach with the simultaneous need to induce an immune response that may limit pathogen invasion once the blood is exposed to an external environment.
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معلومات مُعتمدة: R21 HL153409 United States HL NHLBI NIH HHS; R01 HL141106 United States HL NHLBI NIH HHS; F30 HL165822 United States HL NHLBI NIH HHS; UL1 TR001453 United States TR NCATS NIH HHS; R01 HL142152 United States HL NHLBI NIH HHS; R01 HL153235 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: blood platelets; complement system proteins; extracellular traps; immunity; megakaryocyte; thrombosis; toll-like receptors
تواريخ الأحداث: Date Created: 20220120 Date Completed: 20220224 Latest Revision: 20240618
رمز التحديث: 20240618
مُعرف محوري في PubMed: PMC8852355
DOI: 10.1161/CIRCRESAHA.121.319821
PMID: 35050690
قاعدة البيانات: MEDLINE
الوصف
تدمد:1524-4571
DOI:10.1161/CIRCRESAHA.121.319821