دورية أكاديمية
أعرض في EDS

Low Serum Levels of Soluble Receptor Activator of Nuclear Factor κ B Ligand (sRANKL) Are Associated with Metabolic Dysregulation and Predict Long-Term Mortality in Critically Ill Patients.

التفاصيل البيبلوغرافية
العنوان: Low Serum Levels of Soluble Receptor Activator of Nuclear Factor κ B Ligand (sRANKL) Are Associated with Metabolic Dysregulation and Predict Long-Term Mortality in Critically Ill Patients.
المؤلفون: Puengel T; Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.; Department of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, Germany., Weber B; Department of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, Germany., Wirtz TH; Department of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, Germany., Buendgens L; Department of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, Germany., Loosen SH; Clinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany., Geisler L; Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany., Özdirik B; Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany., Hamesch K; Department of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, Germany., Jhaisha SA; Department of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, Germany., Brozat JF; Department of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, Germany., Hohlstein P; Department of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, Germany., Eisert A; Hospital Pharmacy, RWTH-University Hospital Aachen, 52074 Aachen, Germany.; Institute of Clinical Pharmacology, RWTH-University Hospital Aachen, 52074 Aachen, Germany., Yagmur E; Institute of Laboratory Medicine, Western Palatinate Hospital, 67655 Kaiserslautern, Germany., Trautwein C; Department of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, Germany., Tacke F; Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM), Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany., Koch A; Department of Medicine III, RWTH-University Hospital Aachen, 52074 Aachen, Germany.
المصدر: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2021 Dec 28; Vol. 12 (1). Date of Electronic Publication: 2021 Dec 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101658402 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4418 (Print) Linking ISSN: 20754418 NLM ISO Abbreviation: Diagnostics (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2011]-
مستخلص: Soluble receptor activator of nuclear factor κ B ligand (sRANKL) is a member of the tumor necrosis factor receptor superfamily, and therefore, involved in various inflammatory processes. The role of sRANKL in the course of bone remodeling via activation of osteoclasts as well as chronic disease progression has been described extensively. However, the potential functional importance of sRANKL in critically ill or septic patients remained unknown. Therefore, we measured sRANKL serum concentrations in 303 critically ill patients, including 203 patients with sepsis and 100 with non-sepsis critical illness. Results were compared to 99 healthy controls. Strikingly, in critically ill patients sRANKL serum levels were significantly decreased at intensive care unit (ICU) admission ( p = 0.011) without differences between sepsis and non-sepsis patients. Inline, sRANKL was correlated with markers of metabolic dysregulation, such as pre-existing diabetes and various adipokines (e.g., adiponectin, leptin receptor). Importantly, overall mortality of critically ill patients in a three-year follow-up was significantly associated with decreased sRANKL serum concentrations at ICU admission ( p = 0.038). Therefore, our study suggests sRANKL as a biomarker in critically ill patients which is associated with poor prognosis and overall survival beyond ICU stay.
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معلومات مُعتمدة: Ta434/5-1 Deutsche Forschungsgemeinschaft; DFG 28510-2 Deutsche Forschungsgemeinschaft; SFB 1382 Deutsche Forschungsgemeinschaft
فهرسة مساهمة: Keywords: adipokine; critical illness; diabetes; glucose metabolism; inflammation; intensive care unit (ICU); prognosis; sepsis; soluble receptor activator of nuclear factor κ B ligand (sRANKL)
تواريخ الأحداث: Date Created: 20220121 Latest Revision: 20220128
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8774641
DOI: 10.3390/diagnostics12010062
PMID: 35054232
قاعدة البيانات: MEDLINE
الوصف
تدمد:2075-4418
DOI:10.3390/diagnostics12010062