تقرير
Longitudinal Study of SNCA Rep1 Polymorphism on Executive Function in Early Parkinson's Disease.
| العنوان: | Longitudinal Study of SNCA Rep1 Polymorphism on Executive Function in Early Parkinson's Disease. |
|---|---|
| المؤلفون: | Tan YJ; Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.; Parkinson's Disease and Movement Disorders Centre, USA Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore., Saffari SE; Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.; Center for Quantitative Medicine, Duke-NUS Medical School, National University of Singapore, Singapore., Zhao Y; Department of Clinical Translational Research, Singapore General Hospital, Singapore., Ng EYL; Parkinson's Disease and Movement Disorders Centre, USA Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore.; Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore., Yong ACW; Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.; Parkinson's Disease and Movement Disorders Centre, USA Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore., Ng SYE; Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.; Parkinson's Disease and Movement Disorders Centre, USA Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore., Chia NSY; Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.; Parkinson's Disease and Movement Disorders Centre, USA Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore., Choi X; Parkinson's Disease and Movement Disorders Centre, USA Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore.; Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore., Heng D; Parkinson's Disease and Movement Disorders Centre, USA Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore.; Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore., Neo S; Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.; Parkinson's Disease and Movement Disorders Centre, USA Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore., Xu Z; Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.; Parkinson's Disease and Movement Disorders Centre, USA Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore., Tay KY; Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.; Parkinson's Disease and Movement Disorders Centre, USA Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore., Au WL; Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.; Parkinson's Disease and Movement Disorders Centre, USA Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore., Tan EK; Parkinson's Disease and Movement Disorders Centre, USA Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore.; Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore.; Neuroscience and Behavioural Disorders Program, Duke-NUS Medical School, Singapore., Tan LCS; Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.; Parkinson's Disease and Movement Disorders Centre, USA Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore., Ng ASL; Department of Neurology, National Neuroscience Institute, Tan Tock Seng Hospital, Singapore.; Parkinson's Disease and Movement Disorders Centre, USA Parkinson Foundation International Center of Excellence, National Neuroscience Institute, Singapore.; Neuroscience and Behavioural Disorders Program, Duke-NUS Medical School, Singapore. |
| المصدر: | Journal of Parkinson's disease [J Parkinsons Dis] 2022; Vol. 12 (3), pp. 865-870. |
| نوع المنشور: | Letter; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: IOS Press Country of Publication: Netherlands NLM ID: 101567362 Publication Model: Print Cited Medium: Internet ISSN: 1877-718X (Electronic) Linking ISSN: 18777171 NLM ISO Abbreviation: J Parkinsons Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : IOS Press |
| مواضيع طبية MeSH: | Parkinson Disease*/complications , Parkinson Disease*/genetics , alpha-Synuclein*/genetics, Executive Function ; Genetic Predisposition to Disease ; Humans ; Longitudinal Studies ; Polymorphism, Genetic |
| مستخلص: | The alpha-synuclein gene promoter (SNCA-Rep1) is associated with Parkinson's disease (PD), but its relationship with performance across individual cognitive domains in early PD is unknown. This study aims to investigate Rep1 polymorphism and longitudinal change in cognition in early PD. In this longitudinal study, Rep1 allele lengths ("long" and "short") were determined in 204 early PD patients. All participants underwent annual neuropsychological assessments and followed up for 3 years. Linear-mixed model was performed to investigate the association of Rep1 status and longitudinal change in individual cognitive domains. At 3 years, significant decline in executive function was observed in long Rep1 allele carriers vs short allele carriers, controlling for potential confounders. This is the first longitudinal study demonstrating that long Rep1 allele carriers are at higher risk for executive dysfunction in early PD. |
| فهرسة مساهمة: | Keywords: Parkinson’s disease; SNCA Rep1 promoter; cognition; genetics |
| المشرفين على المادة: | 0 (SNCA protein, human) 0 (alpha-Synuclein) |
| تواريخ الأحداث: | Date Created: 20220124 Date Completed: 20220413 Latest Revision: 20220622 |
| رمز التحديث: | 20231215 |
| DOI: | 10.3233/JPD-213029 |
| PMID: | 35068417 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1877-718X |
|---|---|
| DOI: | 10.3233/JPD-213029 |