دورية أكاديمية
Solid organ transplantations and COVID-19 disease.
| العنوان: | Solid organ transplantations and COVID-19 disease. |
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| المؤلفون: | Yılmaz EA; Division of Pediatric Allergy and Immunology, Sakarya University Medical Faculty, Adapazarı 54100, Sakarya, Turkey., Özdemir Ö; Division of Pediatric Allergy and Immunology, Sakarya University Medical Faculty, Adapazarı 54100, Sakarya, Turkey. ozdemir_oner@hotmail.com. |
| المصدر: | World journal of transplantation [World J Transplant] 2021 Dec 18; Vol. 11 (12), pp. 503-511. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 101608356 Publication Model: Print Cited Medium: Print ISSN: 2220-3230 (Print) Linking ISSN: 22203230 NLM ISO Abbreviation: World J Transplant Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group Original Publication: Hong Kong : Baishideng Pub. Group Co., Ltd. |
| مستخلص: | Tens of thousands of people worldwide became infected with severe acute respiratory syndrome coronavirus-2. Death rate in the general population is about 1%-6%, but this rate rises up to 15% in those with comorbidities. Recent publications showed that the clinical progression of this disease in organ recipients is more destructive, with a fatality rate of up to 14%-25%. We aimed to review the effect of the pandemic on various transplantation patients. Coronavirus disease 2019 (COVID-19) has not only interrupted the lives of waiting list patients'; it has also impacted transplantation strategies, transplant surgeries and broken donation chains. COVID-19 was directly and indirectly accountable for a 73% surplus in mortality of this population as compared to wait listed patients in earlier years. The impact of chronic immunosuppression on outcomes of COVID-19 remains unclear but understanding the immunological mechanisms related to the virus is critically important for the lifetime of transplantation and immune suppressed patients. It is hard to endorse changing anti-rejection therapy, as the existing data evaluation is not adequate to advise substituting tacrolimus with cyclosporine during severe COVID-19 disease. (©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: COVID-19; Comorbidity; Immunosuppression; Mortality; SARS-CoV-2; Solid organ transplantation |
| تواريخ الأحداث: | Date Created: 20220124 Latest Revision: 20220125 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8713305 |
| DOI: | 10.5500/wjt.v11.i12.503 |
| PMID: | 35070786 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2220-3230 |
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| DOI: | 10.5500/wjt.v11.i12.503 |