دورية أكاديمية
Effectiveness of Dalbavancin Compared With Standard of Care for the Treatment of Osteomyelitis: A Real-world Analysis.
العنوان: | Effectiveness of Dalbavancin Compared With Standard of Care for the Treatment of Osteomyelitis: A Real-world Analysis. |
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المؤلفون: | Cain AR; Allegheny Health Network, Pittsburgh, Pennsylvania, USA., Bremmer DN; Allegheny Health Network, Pittsburgh, Pennsylvania, USA., Carr DR; Allegheny Health Network, Pittsburgh, Pennsylvania, USA., Buchanan C; Allegheny Health Network, Pittsburgh, Pennsylvania, USA., Jacobs M; Allegheny Health Network, Pittsburgh, Pennsylvania, USA., Walsh TL; Allegheny Health Network, Pittsburgh, Pennsylvania, USA., Moffa MA; Allegheny Health Network, Pittsburgh, Pennsylvania, USA., Shively NR; Allegheny Health Network, Pittsburgh, Pennsylvania, USA., Trienski TL; Allegheny Health Network, Pittsburgh, Pennsylvania, USA. |
المصدر: | Open forum infectious diseases [Open Forum Infect Dis] 2021 Dec 18; Vol. 9 (2), pp. ofab589. Date of Electronic Publication: 2021 Dec 18 (Print Publication: 2022). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Published by Oxford University Press on behalf of the Infectious Diseases Society of America Country of Publication: United States NLM ID: 101637045 Publication Model: eCollection Cited Medium: Print ISSN: 2328-8957 (Print) Linking ISSN: 23288957 NLM ISO Abbreviation: Open Forum Infect Dis Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Cary, NC : Published by Oxford University Press on behalf of the Infectious Diseases Society of America, [2014]- |
مستخلص: | Background: Preliminary data suggest that the effectiveness of dalbavancin may be similar to current standard-of-care (SoC) treatment options for osteomyelitis with an advantageous dosing schedule. Methods: This was a retrospective, observational cohort study of adult patients diagnosed with osteomyelitis. Patients were matched 1:2 to dalbavancin (administered as 2 doses separated by 1 week) or SoC treatment for osteomyelitis according to the Charlson Comorbidity Index, site of infection, and causative pathogen. The primary objective was to determine the incidence of treatment failure after a 1-year follow-up period. Secondary objectives included hospital length of stay (LOS), infection-related 1-year readmission rates, and treatment-related adverse events. Results: A total of 132 patients received dalbavancin (n = 42) or SoC (n = 90). Baseline characteristics, including rates of surgical intervention, were similar between the 2 treatment groups. Treatment failure was similar between those who received dalbavancin and SoC (21.4% vs 23.3%; P = .81). Patients who received dalbavancin had a shorter hospital LOS (5.2 days vs 7.2 days; P = .01). There was no difference in the rates of infection-related readmission between the dalbavancin and the SoC group (31% vs 31.1%; P = .99). There were numerically fewer adverse events in the dalbavancin group compared with the SoC group (21.4% vs 36.7%; P = .08). Peripherally inserted central catheter line-related complications were reported in 17.8% of patients in the SoC group. Conclusions: Dalbavancin administered as a 2-dose regimen is a safe and effective option for the treatment of osteomyelitis. (© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.) |
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فهرسة مساهمة: | Keywords: dalbavancin; osteomyelitis |
تواريخ الأحداث: | Date Created: 20220124 Latest Revision: 20220430 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC8773963 |
DOI: | 10.1093/ofid/ofab589 |
PMID: | 35071682 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2328-8957 |
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DOI: | 10.1093/ofid/ofab589 |