دورية أكاديمية
Calcineurin inhibitors and related medicines: a cohort study examining England's primary care prescription changes during the COVID-19 pandemic (January 2019 to March 2021).
| العنوان: | Calcineurin inhibitors and related medicines: a cohort study examining England's primary care prescription changes during the COVID-19 pandemic (January 2019 to March 2021). |
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| المؤلفون: | Barrett R; School of Applied Sciences, University of Brighton, Cockcroft Building, Moulsecoomb, Brighton, BN2 4GJ, England. R.Barrett2@Brighton.ac.uk. |
| المصدر: | Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences [Daru] 2022 Jun; Vol. 30 (1), pp. 59-66. Date of Electronic Publication: 2022 Jan 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101125969 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2008-2231 (Electronic) Linking ISSN: 15608115 NLM ISO Abbreviation: Daru Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2018- : Cham : Springer International Publishing Original Publication: Tehran, Iran : The Faculty |
| مواضيع طبية MeSH: | COVID-19*/epidemiology , Calcineurin Inhibitors*/therapeutic use , COVID-19 Drug Treatment*, Cohort Studies ; Communicable Disease Control ; Cyclosporine/therapeutic use ; Graft Rejection/drug therapy ; Humans ; Immunosuppressive Agents/therapeutic use ; Pandemics ; Prescriptions ; Primary Health Care ; Sirolimus/therapeutic use ; Tacrolimus/therapeutic use |
| مستخلص: | Purpose: To examine the impact of the COVID-19 pandemic on calcineurin inhibitors and related prescriptions for community patients in England. Methods: Data from all primary-care patients who had calcineurin inhibitors prescriptions, dispensed in the community in England were included. Descriptive statistics and interrupted time series analysis over 27 months (15 months before and 12 months after 1 st lockdown) was evaluated. Results: Descriptive statistics show that mean values have declined since the pandemic's onset. Over the 27 months: mean Tacrolimus 865,045 doses, standard deviation (SD) 76,147 doses, with 95% CI 834,923, 895,168, (min 567,508, max 1,010,900), ciclosporin 315,496 doses, SD 40,094, 95% CI 299,635, 331,356 (min 191,281, max 382,253) and sirolimus 21,384 doses, SD 2,610, 95% CI 20,352, 22,417 (min 13,022, max 26,156). Analysis of variance between the pre- and post- periods show significant variations in quantities of tacrolimus F 7.432, p = 0.012, ciclosporin F 33.147, p < 0.001 and sirolimus F 18.596, p < 0.001 (1df), mirrored in price analysis. The Interrupted Time Series (ARIMA Modelling) shows declining trends. After the pandemic's onset, a statistically significant downward trend in quantity for tacrolimus p = 0.008 is observed, with an estimated monthly decline of 14,524 doses, ciclosporin p = 0.185, with an estimated decline of 2,161 doses and sirolimus p = 0.002 with an estimated decline of 485 doses, along with declining prices. Conclusion: A decrease in prescription medicines use raises concerns for the care of (renal) transplant patients. Patients are encouraged to discuss their planned care with their doctor, secure supplies and remain adherent to their medication. (© 2022. Springer Nature Switzerland AG.) |
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| فهرسة مساهمة: | Keywords: Acute rejection; COVID-19; Calcineurin inhibitors; Ciclosporin; Follow-up; Graft rejection; Sirolimus; Tacrolimus |
| المشرفين على المادة: | 0 (Calcineurin Inhibitors) 0 (Immunosuppressive Agents) 83HN0GTJ6D (Cyclosporine) W36ZG6FT64 (Sirolimus) WM0HAQ4WNM (Tacrolimus) |
| تواريخ الأحداث: | Date Created: 20220125 Date Completed: 20220519 Latest Revision: 20221207 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC8785924 |
| DOI: | 10.1007/s40199-021-00431-7 |
| PMID: | 35075618 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2008-2231 |
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| DOI: | 10.1007/s40199-021-00431-7 |