دورية أكاديمية
Non-Status Epilepticus female rats show seizure-like behaviors in the chronic phase of Pilocarpine experimental model.
| العنوان: | Non-Status Epilepticus female rats show seizure-like behaviors in the chronic phase of Pilocarpine experimental model. |
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| المؤلفون: | Dal Pai J; Universidade Federal de São Paulo - UNIFESP, Neurology and Neurosurgery Department, São Paulo, SP, Brasil., da Silva JC; Universidade Estadual de Ciências da Saúde de Alagoas - UNCISAL, Maceió, AL, Brasil.; Centro Universitário CESMAC, Faculdade de Medicina, Maceió, AL, Brasil., Sanabria V; Universidade Federal de São Paulo - UNIFESP, Neurology and Neurosurgery Department, São Paulo, SP, Brasil., Amorim RP; Universidade Federal de São Paulo - UNIFESP, Neurology and Neurosurgery Department, São Paulo, SP, Brasil., Predebon G; Universidade Federal de São Paulo - UNIFESP, Neurology and Neurosurgery Department, São Paulo, SP, Brasil., Cossa AC; Universidade Federal de São Paulo - UNIFESP, Neurology and Neurosurgery Department, São Paulo, SP, Brasil., Trindade-Filho E; Universidade Estadual de Ciências da Saúde de Alagoas - UNCISAL, Maceió, AL, Brasil.; Centro Universitário CESMAC, Faculdade de Medicina, Maceió, AL, Brasil., Amado D; Universidade Federal de São Paulo - UNIFESP, Neurology and Neurosurgery Department, São Paulo, SP, Brasil. |
| المصدر: | Brazilian journal of biology = Revista brasleira de biologia [Braz J Biol] 2022 Jan 24; Vol. 83, pp. e237412. Date of Electronic Publication: 2022 Jan 24 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: International Institute of Ecology Country of Publication: Brazil NLM ID: 101129542 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-4375 (Electronic) Linking ISSN: 15196984 NLM ISO Abbreviation: Braz J Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: São Carlos, SP [Brazil] : International Institute of Ecology, [2000]- |
| مواضيع طبية MeSH: | Pilocarpine*/toxicity , Status Epilepticus*/chemically induced, Animals ; Female ; Models, Theoretical ; Muscarinic Agonists/toxicity ; Rats ; Rats, Wistar ; Seizures/chemically induced |
| مستخلص: | Only few studies have focus on animals that received Pilocarpine (Pilo) and did not develop behavioral status epilepticus (SE) and, whether they may become epileptic in the model's chronic phase. Previews works observed mossy fiber sprouting in the hippocampus of Non-SE (NSE) rats, while others observed spontaneous and recurrent seizures (SRS) 6 - 8 months after animals received Pilo. It is known that neuronal excitability is influenced by female hormones, as well as, the occurrence of SE in castrated and non-castrated female rats. However, it is not known whether females that received Pilo and did not show SE, may have SRS. The aim of this work was to investigate whether castrated and non-castrated female rats that did not show behavioral SE after Pilo, will develop SRS in the following one-year. For that, animals received 360 mg/kg of Pilo and were video monitored for 12 months. SE females from castrated and non-castrated groups became epileptic since the first month after drug injection. Epileptic behaviors were identified watching video monitoring recordings in the fast speed. Castrated and Non-castrated NSE animals showed behaviors resembling seizures described by Racine Scale stages 1 - 3. Motor alterations showed by NSE groups could be observed only when recordings were analyzed in slow speed. In addition, behavioral manifestations as, rhythmic head movements, sudden head movements, whole body movements and immobility were also observed in both, SE and NSE groups. We concluded that NSE female rats may have become epileptic. Adding to it, slow speed analysis of motor alterations was essential for the observation of NSE findings, which suggests that possibly many motor alterations have been underestimated in epilepsy experimental research. |
| المشرفين على المادة: | 0 (Muscarinic Agonists) 01MI4Q9DI3 (Pilocarpine) |
| تواريخ الأحداث: | Date Created: 20220126 Date Completed: 20220128 Latest Revision: 20220128 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1590/1519-6984.237412 |
| PMID: | 35081234 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1678-4375 |
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| DOI: | 10.1590/1519-6984.237412 |