دورية أكاديمية
أعرض في EDS

Task-based functional connectivity patterns: Links to adolescent emotion regulation and psychopathology.

التفاصيل البيبلوغرافية
العنوان: Task-based functional connectivity patterns: Links to adolescent emotion regulation and psychopathology.
المؤلفون: Poon JA; Department of Psychiatry and Human Behavior Providence, Emma Pendleton Bradley Hospital/Warren Alpert Medical School of Brown University, RI, United States. Electronic address: jennifer_poon@brown.edu., Thompson JC; Department of Psychology, George Mason University, Fairfax, VA, United States., Chaplin TM; Department of Psychology, George Mason University, Fairfax, VA, United States.
المصدر: Journal of affective disorders [J Affect Disord] 2022 Apr 01; Vol. 302, pp. 33-40. Date of Electronic Publication: 2022 Jan 24.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Emotional Regulation*, Adolescent ; Anxiety ; Anxiety Disorders ; Emotions ; Humans ; Psychopathology
مستخلص: Adolescence is a developmental period characterized by heightened emotional reactivity, neurobiological changes, and increased rates of anxiety and depression. Emotion regulation (ER) difficulties-or the inability to effectively regulate one's emotions-have been theoretically and empirically conceptualized as a transdiagnostic factor implicated in virtually all forms of psychopathology among youth. The current fMRI study investigates how young adolescents' ER abilities longitudinally mediate the relationship between their task-based (n=67) limbic-prefrontal functional connectivity values and subsequent levels of internalizing and externalizing symptoms. Findings revealed that adolescents with stronger limbic-prefrontal connectivity when viewing negative emotional images reported more ER difficulties one year later which, in turn, predicted higher levels of adolescent-reported internalizing and externalizing symptoms (with the exception of ADHD) two years later. This is the only study to date that provides compelling-albeit preliminary-evidence that ER problems longitudinally mediate the association between task-based functional connectivity patterns and future psychological symptoms among adolescents. Of note, participants were only scanned at baseline, limiting our ability to assess change in adolescents' task-based functional connectivity patterns as a function of developing ER abilities or burgeoning psychological symptomology. In sum, rather than conferring risk for any particular disorder, our results suggest that functional connectivity and subsequent ER abilities may serve a transdiagnostic risk factor for psychopathology. These findings may inform future emotion-focused prevention and intervention efforts aimed at youth susceptible to future internalizing and externalizing problems.
(Published by Elsevier B.V.)
References: Dev Psychobiol. 2010 Apr;52(3):216-24. (PMID: 20213754)
J Psychiatr Res. 2015 Feb;61:73-80. (PMID: 25533974)
Nat Neurosci. 2005 Jun;8(6):828-34. (PMID: 15880108)
Science. 2010 Sep 10;329(5997):1358-61. (PMID: 20829489)
Am J Psychiatry. 2009 Jan;166(1):95-102. (PMID: 18923070)
Neuroimage. 1997 Oct;6(3):218-29. (PMID: 9344826)
J Affect Disord. 2012 Jun;139(1):75-84. (PMID: 22401827)
Arch Gen Psychiatry. 2008 May;65(5):568-76. (PMID: 18458208)
J Clin Child Adolesc Psychol. 2002 Sep;31(3):393-8. (PMID: 12149977)
Cereb Cortex. 1996 Mar-Apr;6(2):156-64. (PMID: 8670646)
J Am Acad Child Adolesc Psychiatry. 2011 Aug;50(8):828-37.e3. (PMID: 21784302)
Brain Cogn. 2014 Aug;89:104-11. (PMID: 24556507)
Dev Cogn Neurosci. 2015 Oct;15:11-25. (PMID: 26340451)
Clin Psychol Rev. 2010 Mar;30(2):217-37. (PMID: 20015584)
PLoS Biol. 2009 Jul;7(7):e1000157. (PMID: 19621066)
Neuroimage. 2010 Jan 1;49(1):963-70. (PMID: 19683585)
Ann N Y Acad Sci. 2004 Jun;1021:296-309. (PMID: 15251900)
J Neurosci. 2010 Nov 24;30(47):15726-34. (PMID: 21106812)
Soc Cogn Affect Neurosci. 2012 Jan;7(1):11-22. (PMID: 22228751)
Trends Cogn Sci. 2012 Jun;16(6):322-9. (PMID: 22613872)
Curr Opin Neurobiol. 2005 Apr;15(2):239-44. (PMID: 15831409)
Psychiatry Res. 2011 Sep 30;193(3):151-60. (PMID: 21778039)
J Am Acad Child Adolesc Psychiatry. 2002 Jun;41(6):671-9. (PMID: 12049441)
Biol Psychiatry. 2008 May 15;63(10):927-34. (PMID: 18452757)
Am J Psychiatry. 2008 Jun;165(6):712-20. (PMID: 18281412)
معلومات مُعتمدة: F32 MH127795 United States MH NIMH NIH HHS; R01 DA033431 United States DA NIDA NIH HHS
تواريخ الأحداث: Date Created: 20220127 Date Completed: 20220307 Latest Revision: 20230402
رمز التحديث: 20230403
مُعرف محوري في PubMed: PMC8941670
DOI: 10.1016/j.jad.2022.01.092
PMID: 35085668
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-2517
DOI:10.1016/j.jad.2022.01.092