دورية أكاديمية
أعرض في EDS

Efficacy of an inactivated Zika vaccine against virus infection during pregnancy in mice and marmosets.

التفاصيل البيبلوغرافية
العنوان: Efficacy of an inactivated Zika vaccine against virus infection during pregnancy in mice and marmosets.
المؤلفون: Kim IJ; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA. ijkim@trudeauinstitute.org., Lanthier PA; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., Clark MJ; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., De La Barrera RA; Pilot Bioproduction Facility, Center for Enabling Capabilities, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA., Tighe MP; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., Szaba FM; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., Travis KL; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., Low-Beer TC; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., Cookenham TS; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., Lanzer KG; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., Bernacki DT; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., Johnson LL; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., Schneck AA; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA., Ross CN; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA., Tardif SD; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA., Layne-Colon D; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA., Mdaki SD; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA., Dick EJ Jr; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA., Chuba C; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA., Gonzalez O; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA., Brasky KM; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA., Dutton J; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA., Rutherford JN; Department of Human Development Nursing Science, College of Nursing, University of Illinois Chicago, Chicago, IL, 60612, USA., Coffey LL; Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA., Singapuri A; Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA., Martin CSS; Department of Laboratory Medicine, School of Medicine, University of California at San Francisco, San Francisco, CA, 94158, USA.; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California at Berkeley, Berkeley, CA, 94720, USA., Chiu CY; Department of Laboratory Medicine, School of Medicine, University of California at San Francisco, San Francisco, CA, 94158, USA., Thomas SJ; Division of Infectious Diseases, Institute for Global Health and Translational Sciences, State University of New York, Upstate Medical University, Syracuse, NY, 13210, USA., Modjarrad K; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA., Patterson JL; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA. jpatters@txbiomed.org., Blackman MA; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA. mblackman@trudeauinstitute.org.
المصدر: NPJ vaccines [NPJ Vaccines] 2022 Jan 27; Vol. 7 (1), pp. 9. Date of Electronic Publication: 2022 Jan 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Nature in partnership with the Sealy Center for Vaccine Development Country of Publication: England NLM ID: 101699863 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-0105 (Electronic) Linking ISSN: 20590105 NLM ISO Abbreviation: NPJ Vaccines Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : Springer Nature in partnership with the Sealy Center for Vaccine Development, [2016]-
مستخلص: Zika virus (ZIKV) is a mosquito-borne arbovirus that can cause severe congenital birth defects. The utmost goal of ZIKV vaccines is to prevent both maternal-fetal infection and congenital Zika syndrome. A Zika purified inactivated virus (ZPIV) was previously shown to be protective in non-pregnant mice and rhesus macaques. In this study, we further examined the efficacy of ZPIV against ZIKV infection during pregnancy in immunocompetent C57BL6 mice and common marmoset monkeys (Callithrix jacchus). We showed that, in C57BL/6 mice, ZPIV significantly reduced ZIKV-induced fetal malformations. Protection of fetuses was positively correlated with virus-neutralizing antibody levels. In marmosets, the vaccine prevented vertical transmission of ZIKV and elicited neutralizing antibodies that remained above a previously determined threshold of protection for up to 18 months. These proof-of-concept studies demonstrate ZPIV's protective efficacy is both potent and durable and has the potential to prevent the harmful consequence of ZIKV infection during pregnancy.
(© 2022. The Author(s).)
التعليقات: Erratum in: NPJ Vaccines. 2022 Aug 20;7(1):99. (PMID: 35987764)
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معلومات مُعتمدة: P51 OD011133 United States OD NIH HHS; W81XWH-19-2-0020 U.S. Department of Defense (United States Department of Defense)
تواريخ الأحداث: Date Created: 20220128 Latest Revision: 20220823
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8795414
DOI: 10.1038/s41541-021-00426-0
PMID: 35087081
قاعدة البيانات: MEDLINE
الوصف
تدمد:2059-0105
DOI:10.1038/s41541-021-00426-0