دورية أكاديمية
Risk Reversal of Oral, Pharyngeal and Oesophageal Cancers after Cessation of Betel Quid Users: A Systematic Review and Meta-Analysis.
| العنوان: | Risk Reversal of Oral, Pharyngeal and Oesophageal Cancers after Cessation of Betel Quid Users: A Systematic Review and Meta-Analysis. |
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| المؤلفون: | Gupta R; ICMR-National Institute of Cancer Prevention and Research, I-7, Sector-39, Noida, IN., Mariano LC; UNIPRO, Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), CESPU, Gandra, Portugal and Medicine and Oral Surgery Department, Instituto Universitário de Ciências da Saúde (IUCS), Gandra, PT., Nethan ST; School of Preventive Oncology, Patna, IN., Kedar A; Program Officer QC Process, STOP C clinical trial, YRGCARE, Delhi, IN., Sinha DN; School of Preventive Oncology, Patna, IN., Warnakulasuriya S; Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, WHO Collaborating Centre for Oral Cancer, London, United Kingdom, GB., Monteiro L; UNIPRO, Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), CESPU, Gandra, Portugal and Medicine and Oral Surgery Department, Instituto Universitário de Ciências da Saúde (IUCS), Gandra, PT., Sharma S; Independent researcher, IN., Gupta S; ICMR-National Institute of Cancer Prevention and Research, I-7, Sector-39, Noida, IN., Singh S; ICMR-National Institute of Cancer Prevention and Research, I-7, Sector-39, Noida, IN.; WHO FCTC Global Knowledge Hub on Smokeless Tobacco, ICMR-National Institute of Cancer Prevention and Research, I-7, Sector-39, Noida, IN., Straif K; ISGlobal, Barcelona, Spain, and Boston College, Chestnut Hill, MA, USA. |
| المصدر: | Annals of global health [Ann Glob Health] 2022 Jan 11; Vol. 88 (1), pp. 5. Date of Electronic Publication: 2022 Jan 11 (Print Publication: 2022). |
| نوع المنشور: | Journal Article; Meta-Analysis; Review; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Ubiquity Press Country of Publication: United States NLM ID: 101620864 Publication Model: eCollection Cited Medium: Internet ISSN: 2214-9996 (Electronic) Linking ISSN: 22149996 NLM ISO Abbreviation: Ann Glob Health Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2018- : London : Ubiquity Press Original Publication: Philadelphia, PA : Elsevier Inc., [2014]- |
| مواضيع طبية MeSH: | Esophageal Neoplasms*/epidemiology , Mouth Neoplasms*/epidemiology, Areca/adverse effects ; Humans ; Mastication ; Nicotiana |
| مستخلص: | Background: Areca nut (AN), the principal ingredient of betel quid (BQ) has been categorized as a human carcinogen associated with various cancers of upper aerodigestive tract. However, there has been no attempt at summarizing the risk reversal of oral and other cancers after cessation of BQ with or without tobacco (BQ+T/BQ-T). Objective: To analyze the effect of cessation of betel quid without tobacco (BQ-T) and with tobacco (BQ+T) on reversal of the risk of oral, pharyngeal and oesophageal cancers. Methods: A systematic literature search was conducted for publications evaluating risk of these three cancers among current and former users of BQ-T or BQ+T. The overall as well as subgroup meta-relative risks (meta-RR) were estimated using random-effect models. Results: A total of 14 studies, seven each providing estimates for BQ-T and BQ+T, were identified. For BQ-T and oral cancer, a 28.9% risk reversal was observed among former users (meta-RR 5.61, 95% CI 2.24-14.04) compared to current users (meta-RR 7.89, 95% CI 3.90-15.98). A risk reversal of 48% was noted for pharyngeal cancer - former users (meta-RR 2.50, 95% CI 1.43-4.38), current users (meta-RR 4.81, 95% CI 2.05-11.30). For oesophageal cancer, no appreciable difference in risk was observed between current and former users.For BQ+T and oral cancer the overall meta-RR indicated a higher risk in former than in current users. However, sensitivity analysis including only better-quality studies showed a modestly lower cancer risk in former than in current users. Compared to current users, the risk in former users who quit less than 10 years ago (meta-RR 1.21, 95% CI 0.90-1.63) was increased, but decreased in former users who quit more than 10 years ago (meta-RR 0.72, 95% CI 0.48-1.07). Conclusion: Our analysis highlights for the first time the potential of risk reversal for oral and pharyngeal cancers following cessation of BQ-T and for oral cancer in long-term quitters (greater than 10 years) of BQ+T. The suggestive evidence from this systematic review further supports the imperative need of a strong policy to reduce the initiation of BQ use and inclusion of interventions for BQ cessation in cancer control efforts especially in geographic regions where BQ chewing is prevalent. Competing Interests: The authors have no competing interests to declare. (Copyright: © 2022 The Author(s).) |
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| تواريخ الأحداث: | Date Created: 20220128 Date Completed: 20220503 Latest Revision: 20231213 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8757388 |
| DOI: | 10.5334/aogh.3643 |
| PMID: | 35087705 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2214-9996 |
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| DOI: | 10.5334/aogh.3643 |