دورية أكاديمية
Nasal Air Puff Promotes Default Mode Network Activity in Mechanically Ventilated Comatose Patients: A Noninvasive Brain Stimulation Approach.
| العنوان: | Nasal Air Puff Promotes Default Mode Network Activity in Mechanically Ventilated Comatose Patients: A Noninvasive Brain Stimulation Approach. |
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| المؤلفون: | Salimi M; Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Javadi AH; School of Psychology, University of Kent, Canterbury, UK; School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran., Nazari M; Electrical Engineering Department, Sharif University of Technology, Tehran, Iran; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark; The Danish Research Institute of Translational Neuroscience (DANDRITE), Department of Biomedicine, Aarhus University, Aarhus, Denmark., Bamdad S; Department of Biomedical Engineering, Faculty of Engineering, Shahed University, Tehran, Iran., Tabasi F; Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; Institute for Brain Sciences and Cognition, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Parsazadegan T; Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Ayene F; Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Karimian M; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Gholami-Mahtaj L; Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran., Shadnia S; Department of Clinical Toxicology, Excellence Center of Clinical Toxicology, Loghman Hakim Hospital Poison Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Jamaati H; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Salimi A; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Raoufy MR; Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; Institute for Brain Sciences and Cognition, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address: raoufy@modares.ac.ir. |
| المصدر: | Neuromodulation : journal of the International Neuromodulation Society [Neuromodulation] 2022 Dec; Vol. 25 (8), pp. 1351-1363. Date of Electronic Publication: 2022 Jan 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 9804159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-1403 (Electronic) Linking ISSN: 10947159 NLM ISO Abbreviation: Neuromodulation Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : [New York] : Elsevier Original Publication: Malden, MA : Blackwell Science, c1998- |
| مواضيع طبية MeSH: | Coma*/diagnostic imaging , Coma*/therapy , Respiration, Artificial*, Humans ; Female ; Default Mode Network ; Brain/physiology ; Electroencephalography ; Magnetic Resonance Imaging ; Brain Mapping ; Neural Pathways |
| مستخلص: | Objectives: Coma state and loss of consciousness are associated with impaired brain activity, particularly gamma oscillations, that integrate functional connectivity in neural networks, including the default mode network (DMN). Mechanical ventilation (MV) in comatose patients can aggravate brain activity, which has decreased in coma, presumably because of diminished nasal airflow. Nasal airflow, known to drive functional neural oscillations, synchronizing distant brain networks activity, is eliminated by tracheal intubation and MV. Hence, we proposed that rhythmic nasal air puffing in mechanically ventilated comatose patients may promote brain activity and improve network connectivity. Materials and Methods: We recorded electroencephalography (EEG) from 15 comatose patients (seven women) admitted to the intensive care unit because of opium poisoning and assessed the activity, complexity, and connectivity of the DMN before and during the nasal air-puff stimulation. Nasal cavity air puffing was done through a nasal cannula controlled by an electrical valve (open duration of 630 ms) with a frequency of 0.2 Hz (ie, 12 puff/min). Results: Our analyses demonstrated that nasal air puffing enhanced the power of gamma oscillations (30-100 Hz) in the DMN. In addition, we found that the coherence and synchrony between DMN regions were increased during nasal air puffing. Recurrence quantification and fractal dimension analyses revealed that EEG global complexity and irregularity, typically seen in wakefulness and conscious state, increased during rhythmic nasal air puffing. Conclusions: Rhythmic nasal air puffing, as a noninvasive brain stimulation method, opens a new window to modifying the brain connectivity integration in comatose patients. This approach may potentially influence comatose patients' outcomes by increasing brain reactivity and network connectivity. (Copyright © 2021 International Neuromodulation Society. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Coma state; default mode network; nasal air puff; noninvasive brain stimulation |
| تواريخ الأحداث: | Date Created: 20220128 Date Completed: 20221207 Latest Revision: 20221207 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.neurom.2021.11.003 |
| PMID: | 35088756 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1525-1403 |
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| DOI: | 10.1016/j.neurom.2021.11.003 |