Schistosoma mansoni: structural damage after treatment with oxamniquine.

التفاصيل البيبلوغرافية
العنوان:	Schistosoma mansoni: structural damage after treatment with oxamniquine.
المؤلفون:	Magalhães Filho A; Centro de Pesquisas Aggeu Magalhães--FIOCRUZ, Recife, PE, Brasil., de Melo ME, Padovan PA, Padovan IP
المصدر:	Memorias do Instituto Oswaldo Cruz [Mem Inst Oswaldo Cruz] 1987; Vol. 82 Suppl 4, pp. 347-52.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Instituto Oswaldo Cruz Country of Publication: Brazil NLM ID: 7502619 Publication Model: Print Cited Medium: Print ISSN: 0074-0276 (Print) Linking ISSN: 00740276 NLM ISO Abbreviation: Mem Inst Oswaldo Cruz Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Rio de Janeiro : Instituto Oswaldo Cruz
مواضيع طبية MeSH:	Nitroquinolines/pharmacology , Oxamniquine/pharmacology , Schistosoma mansoni/*drug effects, Animals ; Male ; Mice ; Microscopy, Electron ; Microscopy, Electron, Scanning ; Schistosoma mansoni/ultrastructure
مستخلص:	The effects of a single dose (100 mg/kg-body weight of mouse) of oxamniquine on the worm's tegument and paranchyma in relation to the process of immunological granulomatous reaction of the host's liver are described under light and electron microscopy (EM). The lesions caused by the drug are sequentially and simultaneously described in form of swelling, surface bulble and disruption with erosions. Ulceration in the tubercules with loss of spines is often more extensive and severe in male worms and concentration of host's mononuclear cells is observed. The possible role of host's immune response is discussed.
المشرفين على المادة:	0 (Nitroquinolines) 0O977R722D (Oxamniquine)
تواريخ الأحداث:	Date Created: 19870101 Date Completed: 19890901 Latest Revision: 20190516
رمز التحديث:	20221213
DOI:	10.1590/s0074-02761987000800067
PMID:	3509191
قاعدة البيانات:	MEDLINE

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تدمد:	0074-0276
DOI:	10.1590/s0074-02761987000800067