دورية أكاديمية
Production of More Potent Anti-Candida Labdane Diterpenes by Biotransformation Using Cunninghamella elegans.
| العنوان: | Production of More Potent Anti-Candida Labdane Diterpenes by Biotransformation Using Cunninghamella elegans. |
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| المؤلفون: | Sousa IP; Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil., De Sousa Teixeira MV; Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil., Freitas JA; Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil., Ferreira AG; Laboratory of Nuclear Magnetic Resonance, Chemistry Department, Federal University of São Carlos, São Carlos, 13565-905, SP, Brazil., Pires LM; Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil., Santos RA; Nucleus of Research in Sciences and Technology, University of Franca, Franca, 14404-600, SP, Brazil., Heleno VCG; Nucleus of Research in Sciences and Technology, University of Franca, Franca, 14404-600, SP, Brazil., Furtado NAJC; Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Av. do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil. |
| المصدر: | Chemistry & biodiversity [Chem Biodivers] 2022 Mar; Vol. 19 (3), pp. e202100757. Date of Electronic Publication: 2022 Feb 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004- |
| مواضيع طبية MeSH: | Candida*/metabolism , Diterpenes*/metabolism , Diterpenes*/pharmacology, Antifungal Agents/pharmacology ; Biotransformation ; Cunninghamella ; Fluconazole ; Microbial Sensitivity Tests |
| مستخلص: | Candida species are responsible for causing invasive candidiasis with high mortality rate and their resistance to available antifungal drugs is a major clinical challenge. Biotransformation process of the labdane diterpene ent-labd-8(17)-en-15,18-dioic acid (1) carried out with Cunninghamella elegans afforded five new derivatives (compounds 2-6). Unusual regioselective hydroxylation of the methyl group at the C-20 position of labdane-type diterpene was achieved and all compounds were subjected to cytotoxicity and antifungal evaluations. Compound 1 and its derivatives were not cytotoxic to normal (MCF-10A) and tumor (MCF-7) cell lines. Compounds 2 and 3 exhibited fungistatic activity against all tested Candida strains at lower concentrations than fluconazole. Both compounds also showed the strongest fungicidal activity against C. albicans, which is the most prevalent fungal agent involved in candidemia. (© 2022 Wiley-VHCA AG, Zurich, Switzerland.) |
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| معلومات مُعتمدة: | 2011/13630-7 São Paulo Research Foundation, FAPESP; 2016/25201-7 São Paulo Research Foundation, FAPESP; 306345/2016-1 National Council for Scientific and Technological Development, CNPq; 301924/2019-8 National Council for Scientific and Technological Development, CNPq; 001 Coordination for the Improvement of Higher Education Personnel |
| فهرسة مساهمة: | Keywords: Cunninghamella elegans; anti-Candida activity; biotransformation; labdane diterpenes |
| المشرفين على المادة: | 0 (Antifungal Agents) 0 (Diterpenes) 8VZV102JFY (Fluconazole) |
| SCR Organism: | Cunninghamella elegans |
| تواريخ الأحداث: | Date Created: 20220129 Date Completed: 20220322 Latest Revision: 20220322 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/cbdv.202100757 |
| PMID: | 35092349 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1612-1880 |
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| DOI: | 10.1002/cbdv.202100757 |