دورية أكاديمية
Galactomannan of Delonix regia seeds modulates cytokine expression and oxidative stress eliciting anti-inflammatory and healing effects in mice cutaneous wound.
| العنوان: | Galactomannan of Delonix regia seeds modulates cytokine expression and oxidative stress eliciting anti-inflammatory and healing effects in mice cutaneous wound. |
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| المؤلفون: | Lima IC; Superior Institute of Biomedical Sciences, State University of Ceará, Av. Dr. Silas Munguba 1700, 60740-000 Fortaleza, CE, Brazil., Castro RR; Faculty of Philosophy Dom Aureliano Matos, State University of Ceará, Av. Dom Aureliano Matos, 2000, Limoeiro do Norte, CE 62930-000, Brazil., Adjafre BL; Superior Institute of Biomedical Sciences, State University of Ceará, Av. Dr. Silas Munguba 1700, 60740-000 Fortaleza, CE, Brazil., Sousa SHAF; Superior Institute of Biomedical Sciences, State University of Ceará, Av. Dr. Silas Munguba 1700, 60740-000 Fortaleza, CE, Brazil., de Paula DS; Department of Dental Clinic, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, State University of Ceará, Street Alexandre Baraúna 949, 60430-160 Fortaleza, CE, Brazil., Alves APNN; Department of Dental Clinic, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, State University of Ceará, Street Alexandre Baraúna 949, 60430-160 Fortaleza, CE, Brazil., Silva PGB; Department of Dental Clinic, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, State University of Ceará, Street Alexandre Baraúna 949, 60430-160 Fortaleza, CE, Brazil; Christus University Center (Unichristus), Street João Adolfo Gurgel 133, 60190-180 Fortaleza, CE, Brazil., Assreuy AMS; Superior Institute of Biomedical Sciences, State University of Ceará, Av. Dr. Silas Munguba 1700, 60740-000 Fortaleza, CE, Brazil. Electronic address: anassreuy@gmail.com., Mota MRL; Department of Dental Clinic, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, State University of Ceará, Street Alexandre Baraúna 949, 60430-160 Fortaleza, CE, Brazil. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2022 Apr 01; Vol. 203, pp. 342-349. Date of Electronic Publication: 2022 Jan 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مواضيع طبية MeSH: | Cytokines*/metabolism , Fabaceae*/metabolism, Animals ; Anti-Inflammatory Agents/metabolism ; Anti-Inflammatory Agents/pharmacology ; Female ; Galactose/analogs & derivatives ; Mannans ; Mice ; Oxidative Stress ; Rats ; Rats, Wistar ; Seeds/metabolism ; Skin ; Wound Healing |
| مستخلص: | The galactomannans property of forming viscous solutions, along with the traditional use of Delonix regia as anti-inflammatory, antinociceptive and wound healing, justify the investigation of the healing mechanism of Delonix regia galactomannan (GM-DR) in a model of excisional cutaneous wound. GM-DR (% 0.01-1) was topically applied to the wounds of female Swiss mice during 14 days. The wound healing effect of GM-DR was evaluated by the following parameters: wound closure and clinical signs (hyperemia, edema and exudate by macroscopy, nociception by analgesimetry), oxidative stress markers (malondialdehyde - MDA, reduced glutathione - GSH) by ELISA, histopathological (HE and Picrosirius red), and histomorphometric (collagenesis, blood vessels, polymorphonuclear, mononuclear, fusiform cells) and immunohistochemistry (inflammatory and growth factor mediators) by tissue microarrayer. GM-DR reduced wound area (7-14th day) and hypernociception (6 h - 5th day), leukocyte infiltration (2 -7th days), expression and levels of IL-1β (2th day), IL-6 (2th day), MDA (44% - 2th day), and increased fusiform cells, granulation tissue, collagen deposition, GSH (25 - 50%, 2-5th day), expression of the transforming growth factor beta (TGF-β) (7-10th day) and smooth muscle alpha actin (α-SMA) (7-14th day). In conclusion, GM-DR accelerates the mice healing process acting both in the inflammatory and proliferative phases. (Copyright © 2022 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Inflammation; Plant polysaccharides; Wound healing |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (Cytokines) 0 (Mannans) 11078-30-1 (galactomannan) X2RN3Q8DNE (Galactose) |
| تواريخ الأحداث: | Date Created: 20220130 Date Completed: 20220331 Latest Revision: 20220401 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.ijbiomac.2022.01.144 |
| PMID: | 35093436 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0003 |
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| DOI: | 10.1016/j.ijbiomac.2022.01.144 |