دورية أكاديمية
Staphylococcus aureus and Acinetobacter baumannii Inhibit Osseointegration of Orthopedic Implants.
| العنوان: | Staphylococcus aureus and Acinetobacter baumannii Inhibit Osseointegration of Orthopedic Implants. |
|---|---|
| المؤلفون: | Choe H; Department of Orthopaedics, Case Western Reserve Universitygrid.67105.35, Cleveland, Ohio, USA.; Department of Orthopaedics, Yokohama City University, Yokohama, Kanagawa, Japan., Tatro JM; Department of Orthopaedics, Case Western Reserve Universitygrid.67105.35, Cleveland, Ohio, USA., Hausman BS; Department of Orthopaedics, Case Western Reserve Universitygrid.67105.35, Cleveland, Ohio, USA., Hujer KM; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA., Marshall SH; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA., Akkus O; Department of Mechanical Engineering, Case Western Reserve University, Cleveland, Ohio, USA., Rather PN; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.; Research Service, Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA., Lee Z; Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA., Bonomo RA; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA.; Medical Service and GRECC, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Greenfield EM; Department of Orthopaedics, Case Western Reserve Universitygrid.67105.35, Cleveland, Ohio, USA.; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA. |
| المصدر: | Infection and immunity [Infect Immun] 2022 Mar 17; Vol. 90 (3), pp. e0066921. Date of Electronic Publication: 2022 Jan 31. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : American Society For Microbiology Original Publication: [Bethesda, Md.] American Society for Microbiology. |
| مواضيع طبية MeSH: | Acinetobacter baumannii* , Osteomyelitis*/etiology , Staphylococcal Infections*/microbiology, Animals ; Cytokines/therapeutic use ; Mice ; Osseointegration ; Staphylococcus aureus |
| مستخلص: | Bacterial infections routinely cause inflammation and thereby impair osseointegration of orthopedic implants. Acinetobacter spp., which cause osteomyelitis following trauma, on or off the battlefield, were, however, reported to cause neither osteomyelitis nor osteolysis in rodents. We therefore compared the effects of Acinetobacter strain M2 to those of Staphylococcus aureus in a murine implant infection model. Sterile implants and implants with adherent bacteria were inserted in the femur of mice. Bacterial burden, levels of proinflammatory cytokines, and osseointegration were measured. All infections were localized to the implant site. Infection with either S. aureus or Acinetobacter strain M2 increased the levels of proinflammatory cytokines and the chemokine CCL2 in the surrounding femurs, inhibited bone formation around the implant, and caused loss of the surrounding cortical bone, leading to decreases in both histomorphometric and biomechanical measures of osseointegration. Genetic deletion of TLR2 and TLR4 from the mice partially reduced the effects of Acinetobacter strain M2 on osseointegration but did not alter the effects of S. aureus. This is the first report that Acinetobacter spp. impair osseointegration of orthopedic implants in mice, and the murine model developed for this study will be useful for future efforts to clarify the mechanism of implant failure due to Acinetobacter spp. and to assess novel diagnostic tools or therapeutic agents. |
| References: | J Orthop Res. 2002 Jan;20(1):1-8. (PMID: 11855378) Methods Mol Biol. 2019;1946:271-287. (PMID: 30798563) Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5094-E5102. (PMID: 28607050) J Trauma. 2008 Feb;64(2 Suppl):S163-8; discussion S168. (PMID: 18376160) Crit Care Med. 2013 Aug;41(8):1915-8. (PMID: 23782965) Int J Artif Organs. 2005 Nov;28(11):1172-80. (PMID: 16353124) J Immunol. 2013 Jul 1;191(1):337-44. (PMID: 23720811) J Pediatr Orthop. 2013 Apr-May;33(3):e28-33. (PMID: 23482277) Nat Rev Rheumatol. 2015 Mar;11(3):189-94. (PMID: 25422000) Antimicrob Agents Chemother. 2006 Dec;50(12):4114-23. (PMID: 17000742) Osteoarthritis Cartilage. 2009 Jun;17(6):735-42. (PMID: 19136283) Stem Cells. 2011 Oct;29(10):1601-10. (PMID: 21809421) Crit Care Med. 2013 Aug;41(8):2042-4. (PMID: 23863241) Biomaterials. 2006 Apr;27(11):2331-9. (PMID: 16364434) Clin Infect Dis. 2007 Aug 15;45(4):409-15. (PMID: 17638186) Clin Orthop Relat Res. 2014 Dec;472(12):3709-17. (PMID: 25034980) J Clin Microbiol. 2006 Jul;44(7):2630-4. (PMID: 16825400) PLoS One. 2012;7(2):e30673. (PMID: 22347396) J Orthop Res. 2019 Oct;37(10):2067-2076. (PMID: 31329305) J Immunol. 2014 Apr 15;192(8):3778-92. (PMID: 24646737) J Long Term Eff Med Implants. 2014;24(4):283-96. (PMID: 25747031) Bone. 2006 Jun;38(6):845-52. (PMID: 16377271) J Bone Joint Surg Am. 2017 Mar 15;99(6):e25. (PMID: 28291188) Front Microbiol. 2019 Jul 17;10:1601. (PMID: 31379771) PLoS One. 2010 Sep 07;5(9):e12580. (PMID: 20830204) Mol Cell Endocrinol. 2009 Oct 30;310(1-2):30-9. (PMID: 18805458) Genome Announc. 2013 Nov 07;1(6):. (PMID: 24201195) J Immunol. 2016 May 15;196(10):4196-203. (PMID: 27053759) PLoS One. 2012;7(10):e47397. (PMID: 23082163) Cell Microbiol. 2012 Sep;14(9):1336-44. (PMID: 22640368) Bone. 2006 Apr;38(4):509-20. (PMID: 16316790) mBio. 2014 May 27;5(3):e01076-14. (PMID: 24865555) Pathol Res Pract. 2008;204(10):695-706. (PMID: 18757139) In Vivo. 2014 Mar-Apr;28(2):189-96. (PMID: 24632972) BMC Infect Dis. 2019 Jan 31;19(1):103. (PMID: 30704410) Clin Orthop Relat Res. 2019 Nov;477(11):2588-2598. (PMID: 31283731) Int J Antimicrob Agents. 2019 Apr;53(4):483-490. (PMID: 30611868) J Bone Miner Res. 2003 Oct;18(10):1766-74. (PMID: 14584886) J Bacteriol. 2008 May;190(9):3386-92. (PMID: 18281398) Clin Infect Dis. 2007 Jun 15;44(12):1577-84. (PMID: 17516401) J Biol Chem. 2010 Oct 15;285(42):32378-84. (PMID: 20729214) J Biochem. 2013 Jul;154(1):29-39. (PMID: 23750028) Infect Immun. 2014 Nov;82(11):4458-65. (PMID: 25114113) Biomaterials. 2005 Apr;26(11):1271-86. (PMID: 15475057) mBio. 2012 Oct 02;3(5):. (PMID: 23033474) Mucosal Immunol. 2018 Jan;11(1):257-272. (PMID: 28612844) J Rehabil Res Dev. 2001 Mar-Apr;38(2):175-81. (PMID: 11392650) Mol Med Rep. 2017 Jun;15(6):4061-4068. (PMID: 28487993) Infect Immun. 2016 Jun 23;84(7):1957-1965. (PMID: 27091926) J Immunol. 2013 Mar 1;190(5):2159-68. (PMID: 23365077) J Orthop Res. 2008 Jan;26(1):96-105. (PMID: 17676625) J Arthroplasty. 1999 Apr;14(3):355-68. (PMID: 10220191) Ann Surg. 2007 May;245(5):803-11. (PMID: 17457175) Cell Host Microbe. 2013 Jun 12;13(6):759-72. (PMID: 23768499) N Engl J Med. 2008 Mar 20;358(12):1271-81. (PMID: 18354105) Nat Rev Microbiol. 2007 Dec;5(12):939-51. (PMID: 18007677) J Infect. 2010 Feb;60(2):154-61. (PMID: 19748521) J Microbiol Methods. 2012 Jul;90(1):25-8. (PMID: 22534140) Clin Orthop Relat Res. 2015 Sep;473(9):2898-907. (PMID: 25953690) Eur Cell Mater. 2021 Oct 21;42:334-374. (PMID: 34672359) JCI Insight. 2018 Sep 6;3(17):. (PMID: 30185667) J Immunol. 1992 Feb 1;148(3):788-94. (PMID: 1309841) Cell Metab. 2015 Mar 3;21(3):502.e1. (PMID: 25738464) Clin Chim Acta. 2010 Nov 11;411(21-22):1570-9. (PMID: 20633546) Spine J. 2014 Feb 1;14(2):255-62. (PMID: 24231777) Clin Orthop Relat Res. 2011 Jan;469(1):274-82. (PMID: 20668970) Sci Rep. 2017 Dec 12;7(1):17429. (PMID: 29234083) Biomolecules. 2020 May 06;10(5):. (PMID: 32384624) J Infect Dis. 2015 Apr 15;211(8):1296-305. (PMID: 25378635) J Orthop Res. 2009 Aug;27(8):1008-15. (PMID: 19173261) J Orthop Res. 2012 Mar;30(3):335-40. (PMID: 21837686) Am J Infect Control. 2010 Jun;38(5 Suppl 1):S25-33. (PMID: 20569853) Vet J. 2019 Aug;250:44-54. (PMID: 31383419) Bone. 2011 Nov;49(5):923-30. (PMID: 21801863) J Immunol. 2007 Jan 15;178(2):1068-76. (PMID: 17202370) J Oral Microbiol. 2011 Jan 17;3:. (PMID: 21547019) Bone. 2013 Jan;52(1):93-101. (PMID: 22995462) PLoS One. 2012;7(6):e40019. (PMID: 22768201) |
| معلومات مُعتمدة: | I01 BX001974 United States BX BLRD VA; R01 AI072219 United States AI NIAID NIH HHS; R01AI072219 HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) |
| فهرسة مساهمة: | Keywords: Acinetobacter; Staphylococcus; bioluminescence; implant infection; osseointegration |
| المشرفين على المادة: | 0 (Cytokines) |
| تواريخ الأحداث: | Date Created: 20220131 Date Completed: 20220420 Latest Revision: 20220918 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8929340 |
| DOI: | 10.1128/iai.00669-21 |
| PMID: | 35099267 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-5522 |
|---|---|
| DOI: | 10.1128/iai.00669-21 |