دورية أكاديمية
Loss of EphA7 Expression in Basal Cell Carcinoma by Hypermethylation of CpG Islands in the Promoter Region.
العنوان: | Loss of EphA7 Expression in Basal Cell Carcinoma by Hypermethylation of CpG Islands in the Promoter Region. |
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المؤلفون: | Liu J; Department of Dermatology, Taixing People's Hospital, Jiangsu Taixing 225400, China., Yu N; Department of Radiotherapy, Taixing People's Hospital, Jiangsu Taixing 225400, China., Feng X; Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China., He Y; Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China., Lv K; Department of Dermatology, Taixing People's Hospital, Jiangsu Taixing 225400, China., Zhu H; Department of Dermatology, Taixing People's Hospital, Jiangsu Taixing 225400, China., Wang J; Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China. |
المصدر: | Analytical cellular pathology (Amsterdam) [Anal Cell Pathol (Amst)] 2022 Jan 22; Vol. 2022, pp. 4220786. Date of Electronic Publication: 2022 Jan 22 (Print Publication: 2022). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Hindawi Country of Publication: United States NLM ID: 101541993 Publication Model: eCollection Cited Medium: Internet ISSN: 2210-7185 (Electronic) Linking ISSN: 22107177 NLM ISO Abbreviation: Anal Cell Pathol (Amst) Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2014- : New York : Hindawi Original Publication: Amsterdam : IOS Press |
مواضيع طبية MeSH: | Carcinoma, Basal Cell*/genetics , Carcinoma, Basal Cell*/metabolism , CpG Islands* , DNA Methylation* , Receptor, EphA7*/biosynthesis , Receptor, EphA7*/genetics , Receptor, EphA7*/metabolism , Skin Neoplasms*/genetics , Skin Neoplasms*/metabolism, Humans ; Promoter Regions, Genetic |
مستخلص: | Basal cell carcinoma (BCC) is the most common malignancy worldwide, with increasing incidence. BCCs present low mortality but high morbidity, and its pathogenesis remains unclear. Eph receptors have been implicated in tumorigenesis. EphA7 plays a role as a tumor suppressor in certain cancers. We checked EphA7 expression levels and methylation status in a set of BCCs, benign skin diseases, and compound nevus tissue samples using immunohistochemistry. EphA7 protein was positively expressed in normal basal cells, benign skin diseases, and compound nevus cells, but lost in areas of BCC tissues. We detected hypermethylation in BCC tissue samples with reduced expression of EphA7. There is a significant relationship between the expression level of EphA7 receptor protein and the methylation status of CpG islands in the EphA7 promoter region ( P < 0.001). To our knowledge, this is the first study to report the EphA7 expression profile and hypermethylation of EphA7 in BCC. The role of the EphA7 gene and the status of hypermethylation in tumorigenesis and treatment of BCC warrant further investigation. Competing Interests: The authors declare that no conflict of interest exists. (Copyright © 2022 Jie Liu et al.) |
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المشرفين على المادة: | EC 2.7.10.1 (Receptor, EphA7) |
تواريخ الأحداث: | Date Created: 20220201 Date Completed: 20220404 Latest Revision: 20220531 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC8800629 |
DOI: | 10.1155/2022/4220786 |
PMID: | 35103233 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2210-7185 |
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DOI: | 10.1155/2022/4220786 |