دورية أكاديمية
أعرض في EDS

Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during the mitosis-to-G1 phase transition.

التفاصيل البيبلوغرافية
العنوان: Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during the mitosis-to-G1 phase transition.
المؤلفون: Krenning L; Oncode Institute, Hubrecht Institute - KNAW and University Medical Center Utrecht, Utrecht, Netherlands., Sonneveld S; Oncode Institute, Hubrecht Institute - KNAW and University Medical Center Utrecht, Utrecht, Netherlands., Tanenbaum ME; Oncode Institute, Hubrecht Institute - KNAW and University Medical Center Utrecht, Utrecht, Netherlands.
المصدر: ELife [Elife] 2022 Feb 01; Vol. 11. Date of Electronic Publication: 2022 Feb 01.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Cell Cycle/*genetics , Cell Cycle/*physiology , RNA Stability/*physiology, Cell Line ; Gene Expression Regulation ; HEK293 Cells ; Humans ; Sequence Analysis, RNA ; Transcription Factors/metabolism
مستخلص: Accurate control of the cell cycle is critical for development and tissue homeostasis, and requires precisely timed expression of many genes. Cell cycle gene expression is regulated through transcriptional and translational control, as well as through regulated protein degradation. Here, we show that widespread and temporally controlled mRNA decay acts as an additional mechanism for gene expression regulation during the cell cycle in human cells. We find that two waves of mRNA decay occur sequentially during the mitosis-to-G1 phase transition, and we identify the deadenylase CNOT1 as a factor that contributes to mRNA decay during this cell cycle transition. Collectively, our data show that, akin to protein degradation, scheduled mRNA decay helps to reshape cell cycle gene expression as cells move from mitosis into G1 phase.
Competing Interests: LK, SS, MT No competing interests declared
(© 2022, Krenning et al.)
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فهرسة مساهمة: Keywords: cell biology; cell cycle; chromosomes; gene expression; gene regulation; human; mRNA decay; single-cell sequencing
المشرفين على المادة: 0 (CNOT1 protein, human)
0 (Transcription Factors)
تواريخ الأحداث: Date Created: 20220201 Date Completed: 20220222 Latest Revision: 20230119
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8806192
DOI: 10.7554/eLife.71356
PMID: 35103592
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.71356