دورية أكاديمية
Sex differences in TLR4 expression in SHR do not contribute to sex differences in blood pressure or the renal T cell profile.
| العنوان: | Sex differences in TLR4 expression in SHR do not contribute to sex differences in blood pressure or the renal T cell profile. |
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| المؤلفون: | Belanger KM; Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia., Mohamed R; Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia., Webb RC; Department of Pharmacology, Physiology, and Neuroscience, University of South Carolina, Columbia, South Carolina., Sullivan JC; Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia. |
| المصدر: | American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2022 Apr 01; Vol. 322 (4), pp. R319-R325. Date of Electronic Publication: 2022 Feb 02. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1490 (Electronic) Linking ISSN: 03636119 NLM ISO Abbreviation: Am J Physiol Regul Integr Comp Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, Md. : American Physiological Society |
| مواضيع طبية MeSH: | Hypertension* , Sex Characteristics*, Animals ; Blood Pressure/physiology ; CD8-Positive T-Lymphocytes/metabolism ; Female ; Humans ; Kidney/metabolism ; Male ; Rats ; Rats, Inbred SHR ; Toll-Like Receptor 4/metabolism |
| مستخلص: | Hypertension is a primary risk factor for the development of cardiovascular disease. Mechanisms controlling blood pressure (BP) in men and women are still being investigated; however, there is increasing evidence supporting a role for the innate immune system. Specifically, Toll-like receptors (TLRs), and TLR4 in particular, have been implicated in the development of hypertension in male spontaneously hypertensive rats (SHR). Despite established sex differences in BP control and inflammatory markers in hypertensive males and females, little is known regarding the role of TLR4 in hypertension in females. Our hypotheses were that male SHR have greater TLR4 expression compared with females, and that sex differences in TLR4 contribute to sex differences in BP and the T cell profile. To test these hypotheses, initial studies measured renal TLR4 protein expression in 13-wk-old male and female SHR. Additional SHR were implanted with telemetry devices and randomized to treatment with either IgG or TLR4 neutralizing antibodies. Untreated control male SHR have greater TLR4 protein expression in the kidney compared with females. However, treatment with TLR4 neutralizing antibody for 2 wk did not significantly alter BP in either male or female SHR. Interestingly, neutralization of TLR4 increased renal CD3 + T cells in female SHR, with no alteration in CD4 + T cells or CD8 + T cells in either sex. Taken together, our data indicate that although male SHR have greater renal TLR4 expression than females, TLR4 does not contribute to the higher BP and more proinflammatory renal T cell profile in males versus females. |
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| معلومات مُعتمدة: | P01 HL134604-05 HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) |
| فهرسة مساهمة: | Keywords: gender; inflammation; kidney |
| المشرفين على المادة: | 0 (TLR4 protein, human) 0 (Tlr4 protein, rat) 0 (Toll-Like Receptor 4) |
| تواريخ الأحداث: | Date Created: 20220202 Date Completed: 20220502 Latest Revision: 20230402 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8917934 |
| DOI: | 10.1152/ajpregu.00237.2021 |
| PMID: | 35107023 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1522-1490 |
|---|---|
| DOI: | 10.1152/ajpregu.00237.2021 |