دورية أكاديمية
أعرض في EDS

Cellular and Biochemical Effects of Combined X-Ray Radiation and Storage on Whole Blood.

التفاصيل البيبلوغرافية
العنوان: Cellular and Biochemical Effects of Combined X-Ray Radiation and Storage on Whole Blood.
المؤلفون: Torres Filho IP; Hemorrhage and Edema Control, United States Army Institute of Surgical Research, JBSA Fort Sam Houston, TX, USA., Torres LN; Hemorrhage and Edema Control, United States Army Institute of Surgical Research, JBSA Fort Sam Houston, TX, USA., Barraza D; Hemorrhage and Edema Control, United States Army Institute of Surgical Research, JBSA Fort Sam Houston, TX, USA., Williams CE; Hemorrhage and Edema Control, United States Army Institute of Surgical Research, JBSA Fort Sam Houston, TX, USA., Hildreth K; Hemorrhage and Edema Control, United States Army Institute of Surgical Research, JBSA Fort Sam Houston, TX, USA.
المصدر: Dose-response : a publication of International Hormesis Society [Dose Response] 2022 Jan 29; Vol. 20 (1), pp. 15593258211073100. Date of Electronic Publication: 2022 Jan 29 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 101308899 Publication Model: eCollection Cited Medium: Print ISSN: 1559-3258 (Print) Linking ISSN: 15593258 NLM ISO Abbreviation: Dose Response Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2015- : Thousand Oaks, CA : Sage Publications
Original Publication: Amherst, MA : International Hormesis Society, c2005-
مستخلص: Background: Evaluating the impact of ionizing radiation on stored blood is relevant since blood banks are major assets in emergency conditions such as radiation incident/attack. This study aimed to fill our knowledge gap of combined radiation and storage effects on blood.
Methods: Blood collected from 16 anesthetized rats was anticoagulated, aliquoted into storage bags, and assigned to 8 groups using protocols combining storage (1-day vs 3-day 4 o C) plus irradiation (75 Gy vs 0 Gy - control). Bags were positioned inside an X-ray irradiator (MultiRad-350). Complete blood count, differential white blood cell count, biochemistry, and hemostasis were analyzed (≥7 bags/group).
Results: Na + , bicarbonate, glucose, and pH significantly reduced, while K + , Cl - , and lactate increased by storage. Coagulation measures were not significantly altered after radiation. White blood cell count and most cell types were numerically reduced after radiation, but changes were statistically significant only for monocytes. No significant alterations were noted in aggregation or rotational thromboelastometry parameters between irradiated and control.
Conclusions: Evaluating cellular/biochemical parameters aids in assessing stored blood adequacy after radiation. Data suggest that fresh or cold-stored blood can sustain up to 75 Gy without major critical parameter changes and may remain suitable for use in critically ill patients in military/civilian settings.
Competing Interests: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(© The Author(s) 2022.)
References: Mil Med. 2018 Sep 1;183(suppl_2):44-51. (PMID: 30189061)
Blood. 1984 Jun;63(6):1402-7. (PMID: 6426552)
J Trauma Acute Care Surg. 2019 Nov;87(5):1035-1041. (PMID: 31389912)
Blood Transfus. 2019 Jan;17(1):27-52. (PMID: 30653459)
Blood Cells Mol Dis. 1998 Sep;24(3):385-95; discussion 396-8. (PMID: 10087995)
Shock. 2013 May;39(5):440-6. (PMID: 23481505)
Am J Clin Pathol. 1996 Jul;106(1):6-11. (PMID: 8701934)
Dose Response. 2020 Oct 28;18(4):1559325820962615. (PMID: 33192201)
J Reprod Immunol. 2003 Jun;59(1):39-52. (PMID: 12892902)
Inflammation. 1987 Dec;11(4):401-16. (PMID: 3692576)
Biochem Soc Trans. 1998 Feb;26(1):S86. (PMID: 10909844)
Transfusion. 2016 Mar;56(3):596-604. (PMID: 26718322)
Int J Radiat Oncol Biol Phys. 2003 Oct 1;57(2):500-7. (PMID: 12957263)
FEBS Lett. 2008 Jun 11;582(13):1783-7. (PMID: 18474236)
J Thromb Haemost. 2017 Jan;15(1):163-175. (PMID: 27797452)
Transfus Med Rev. 2020 Oct;34(4):234-241. (PMID: 33051112)
J Trauma Acute Care Surg. 2019 Jul;87(1S Suppl 1):S110-S118. (PMID: 31246914)
Clin Hemorheol Microcirc. 2000;22(2):131-41. (PMID: 10831063)
Transfusion. 2010 Feb;50(2):376-89. (PMID: 19874562)
Phys Med. 2019 Mar;59:107-111. (PMID: 30928058)
PLoS One. 2020 Oct 29;15(10):e0241375. (PMID: 33119684)
PLoS One. 2018 Jan 19;13(1):e0191402. (PMID: 29351567)
Transfusion. 2019 Apr;59(S2):1549-1559. (PMID: 30980756)
Transfus Med. 2000 Dec;10(4):291-303. (PMID: 11123813)
Biology (Basel). 2020 Dec 04;9(12):. (PMID: 33291543)
Exp Anim. 1999 Apr;48(2):107-14. (PMID: 10374072)
Transfusion. 2010 Oct;50(10):2240-8. (PMID: 20529007)
Int J Radiat Biol. 1998 Apr;73(4):435-42. (PMID: 9587082)
فهرسة مساهمة: Keywords: X-ray radiation; aggregometry; cell damage; cold storage; ionizing radiation; platelets; rat; resuscitation; storage lesion; whole blood
تواريخ الأحداث: Date Created: 20220203 Latest Revision: 20220430
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8801673
DOI: 10.1177/15593258211073100
PMID: 35110978
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-3258
DOI:10.1177/15593258211073100