تقرير
Withania somnifera as an Adjunctive Treatment for Refractory Restless Legs Syndrome in Parkinson's Disease: A Case Report.
| العنوان: | Withania somnifera as an Adjunctive Treatment for Refractory Restless Legs Syndrome in Parkinson's Disease: A Case Report. |
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| المؤلفون: | Chaudhari KS; Department of Internal Medicine, Dr. V.M. Government Medical College, Solapur, IND., Tiwari RR; Department of Samhita Siddhanta, Smt. K.G. Mittal Punarvasu Ayurvedic College, Mumbai, IND., Chaudhari SS; Department of Internal Medicine, Seth G.S. Medical College, Mumbai, IND., Joshi SV; Department of Internal Medicine, Dr. V.M. Government Medical College, Solapur, IND., Singh HB; Department of Kayachikitsa, Smt. K.G. Mittal Punarvasu Ayurvedic College, Mumbai, IND. |
| المصدر: | Cureus [Cureus] 2021 Dec 28; Vol. 13 (12), pp. e20775. Date of Electronic Publication: 2021 Dec 28 (Print Publication: 2021). |
| نوع المنشور: | Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Palo Alto, CA : Cureus, Inc. |
| مستخلص: | Non-motor symptoms of Parkinson's disease (PD), such as insomnia and restless legs syndrome (RLS), tend to worsen and become refractory as neurodegeneration progresses. We report the case of a 72-year-old female with a six-year history of PD and two-and-half-year history of insomnia and refractory RLS. We added a neuroprotective agent, Withania somnifera , to the existing treatment regimen for her insomnia. Besides the partial remission of her insomnia and motor symptoms of PD, there was a complete reversal of the RLS symptoms. Withania somnifera has been shown to improve PD symptoms by preventing oxidative damage of the nigrostriatal dopaminergic neurons and improving dopamine levels in the midbrain and corpus striatum. Our case provides the first-time evidence where Withania somnifera added for insomnia caused a complete remission of refractory RLS, possibly due to its anti-apoptotic and pro-dopaminergic actions. Withania somnifera could prove beneficial in cases where the disease advances but further addition of dopamine agonists for refractory RLS is not possible due to the risk of dopamine augmentation. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Chaudhari et al.) |
| References: | Brain. 2009 Sep;132(Pt 9):2403-12. (PMID: 19467991) Mov Disord. 2010;25 Suppl 1:S117-22. (PMID: 20187236) Sleep Med. 2020 Aug;72:28-36. (PMID: 32540634) Neurochem Res. 2014 Dec;39(12):2527-36. (PMID: 25403619) Ann Fam Med. 2008 May-Jun;6(3):253-62. (PMID: 18474889) J Neurophysiol. 2008 Aug;100(2):598-608. (PMID: 18353913) J Ethnopharmacol. 2021 Jun 28;274:113304. (PMID: 32920131) J Ethnopharmacol. 2015 Aug 2;171:264-72. (PMID: 26068424) Brain Behav. 2018 Jun;8(6):e00967. (PMID: 30106239) Sleep Med. 2007 Aug;8(5):455-63. (PMID: 17543579) |
| فهرسة مساهمة: | Keywords: insomnia; parkinson’s disease; restless legs syndrome; sleep disorders; withania somnifera |
| تواريخ الأحداث: | Date Created: 20220203 Latest Revision: 20240405 |
| رمز التحديث: | 20240405 |
| مُعرف محوري في PubMed: | PMC8793665 |
| DOI: | 10.7759/cureus.20775 |
| PMID: | 35111460 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2168-8184 |
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| DOI: | 10.7759/cureus.20775 |