دورية أكاديمية
Factors That Predict the Progression of Non-alcoholic Fatty Liver Disease (NAFLD).
العنوان: | Factors That Predict the Progression of Non-alcoholic Fatty Liver Disease (NAFLD). |
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المؤلفون: | Parameswaran M; Radiology, Massachusetts General Hospital, Boston, USA., Hasan HA; School of Medicine, Hashemite University, Zarqa, JOR., Sadeque J; Internal Medicine, Al Mostaqbal Hospital, Jeddah, SAU., Jhaveri S; Internal Medicine, Smt. Nathiba Hargovandas Lakhmichand Municipal Medical College, Ahmedabad, IND., Avanthika C; Medicine and Surgery, Karnataka Institute of Medical Sciences, Hubli, IND., Arisoyin AE; Internal Medicine, College of Medicine, University of Lagos, Lagos, NGA., Dhanani MB; Internal Medicine, Southwestern University School of Medicine, Cebu City, PHL., Rath SM; Medicine, Srirama Chandra Bhanja Medical College and Hospital, Cuttack, IND. |
المصدر: | Cureus [Cureus] 2021 Dec 28; Vol. 13 (12), pp. e20776. Date of Electronic Publication: 2021 Dec 28 (Print Publication: 2021). |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Palo Alto, CA : Cureus, Inc. |
مستخلص: | Non-alcoholic fatty liver disease (NAFLD) refers to a spectrum of diseases involving the deposition of fat in the hepatocytes of people with little to no alcohol consumption. NAFLD is associated with hypertension, diabetes, obesity, etc. As their prevalence increases, the propensity and severity of NAFLD might increase. As per the recently developed multi-hit hypothesis, factors like oxidative stress, genetic predisposition, lipotoxicity, and insulin resistance have been found to play a key role in the development of NAFLD and its associated complications. This article focuses on NAFLD, its pathophysiology, risk factors, and the various genetic and epigenetic factors involved in its development along with possible treatment modalities. We conducted an all-language literature search on Medline, Cochrane, Embase, and Google Scholar until October 2021. The following search strings and Medical Subject Heading (MeSH) terms were used: "NAFLD," "NASH," "Fibrosis," and "Insulin Resistance." We explored the literature on NAFLD for its epidemiology, pathophysiology, the role of various genes, and how they influence the disease and associated complications about the disease and its hepatic and extrahepatic complications. With its rapidly increasing prevalence rates across the world and serious complications like NASH and hepatocellular carcinoma, NAFLD is becoming a major public health issue and more research is needed to formulate better screening tools and treatment protocols. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Parameswaran et al.) |
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فهرسة مساهمة: | Keywords: demographics; disease progression; human genetics and epigenetics; long-term prognosis; mitochondrial senescence; nonalcoholic fatty liver disease (nafld); treatment choices |
تواريخ الأحداث: | Date Created: 20220203 Latest Revision: 20220204 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC8794413 |
DOI: | 10.7759/cureus.20776 |
PMID: | 35111461 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2168-8184 |
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DOI: | 10.7759/cureus.20776 |