دورية أكاديمية
Reconstruction of regulatory network predicts transcription factors driving the dynamics of zebrafish heart regeneration.
| العنوان: | Reconstruction of regulatory network predicts transcription factors driving the dynamics of zebrafish heart regeneration. |
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| المؤلفون: | Nunes LS; Laboratório de Genômica Estrutural, Programa de Pós-Graduação em Biotecnologia, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Domingues WB; Laboratório de Genômica Estrutural, Programa de Pós-Graduação em Biotecnologia, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Kremer FS; Laboratório de Bioinformática e Proteômica, Programa de Pós-Graduação em Biotecnologia, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Pinhal D; Laboratório Genômica e Evolução Molecular, Departamento de Genética, Instituto de Biociências de Botucatu, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil., Campos VF; Laboratório de Genômica Estrutural, Programa de Pós-Graduação em Biotecnologia, Centro de Desenvolvimento Tecnológico, Universidade Federal de Pelotas, Pelotas, RS, Brazil. Electronic address: fariascampos@gmail.com. |
| المصدر: | Gene [Gene] 2022 Apr 20; Vol. 819, pp. 146242. Date of Electronic Publication: 2022 Jan 31. |
| نوع المنشور: | Journal Article; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0038 (Electronic) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland, 1976- |
| مواضيع طبية MeSH: | Regeneration*, Heart/*physiology , Transcription Factors/*genetics , Zebrafish/*genetics, Animals ; Gene Regulatory Networks ; Transcriptome ; Zebrafish Proteins/genetics |
| مستخلص: | The limited regenerative capacity in mammals has serious implications for cardiac tissue damage. Meanwhile, zebrafish has a high regenerative capacity, but the regulation of the heart healing process has yet to be elucidated. The dynamic nature of cardiac regeneration requires consideration of the inherent temporal dimension of this process. Here, we conducted a systematic review to find genes that define the regenerative cell state of the zebrafish heart. We then performed an in silico temporal gene regulatory network analysis using transcriptomic data from the zebrafish heart regenerative process obtained from databases. In this analysis, the genes found in the systematic review were used to represent the final cell state of the transition process from a non-regenerative cell state to a regenerative state. We found 135 transcription factors driving the cellular state transition process during zebrafish cardiac regeneration, including Hand2, Nkx2.5, Tbx20, Fosl1, Fosb, Junb, Vdr, Wt1, and Tcf21 previously reported for playing a key role in tissue regeneration. Furthermore, we demonstrate that most regulators are activated in the first days post-injury, indicating that the transition from a non-regenerative to a regenerative state occurs promptly. (Copyright © 2022 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Danio rerio; Heart; Regeneration; Regulation; Transcription factors |
| المشرفين على المادة: | 0 (Transcription Factors) 0 (Zebrafish Proteins) |
| تواريخ الأحداث: | Date Created: 20220203 Date Completed: 20220307 Latest Revision: 20220307 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.gene.2022.146242 |
| PMID: | 35114280 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0038 |
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| DOI: | 10.1016/j.gene.2022.146242 |