دورية أكاديمية
أعرض في EDS

Effects of a novel form of intraoperative radiation therapy on quality of life among patients with early-stage breast cancer.

التفاصيل البيبلوغرافية
العنوان: Effects of a novel form of intraoperative radiation therapy on quality of life among patients with early-stage breast cancer.
المؤلفون: Lattimore CM; Department of Surgery, University of Virginia Health System, Charlottesville, VA. Electronic address: cml4wh@virginia.edu., Meneveau MO; Department of Surgery, University of Virginia Health System, Charlottesville, VA., Petroni GR; Division of Translational Research & Applied Statistics, Department of Public Health Sciences, University of Virginia Health System, Charlottesville, VA., Varhegyi NE; Division of Translational Research & Applied Statistics, Department of Public Health Sciences, University of Virginia Health System, Charlottesville, VA., Squeo GC; Department of Surgery, University of Virginia Health System, Charlottesville, VA., Showalter TN; Department of Radiation Oncology, University of Virginia Health System, VA 22908., Showalter SL; Department of Surgery, University of Virginia Health System, Charlottesville, VA. Electronic address: snl2t@virginia.edu.
المصدر: Brachytherapy [Brachytherapy] 2022 May-Jun; Vol. 21 (3), pp. 325-333. Date of Electronic Publication: 2022 Feb 02.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier, 2002- Country of Publication: United States NLM ID: 101137600 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1449 (Electronic) Linking ISSN: 15384721 NLM ISO Abbreviation: Brachytherapy Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Elsevier, 2002-
مواضيع طبية MeSH: Brachytherapy*/methods , Breast Neoplasms*/radiotherapy , Breast Neoplasms*/surgery, Breast ; Clinical Trials, Phase II as Topic ; Female ; Humans ; Quality of Life ; Surveys and Questionnaires
مستخلص: Purpose: To investigate patient-perceived quality of life (QOL) among patients treated with a novel form of breast intraoperative radiation therapy (PB-IORT).
Methods and Materials: Patients treated with PB-IORT as part of a phase II clinical trial from 2013 to 2020 were identified. Patients were given the European Organization for Research and Treatment of Cancer (EORTC) core 30-item Quality of Life Questionnaire (QLQ-C30) encompassing global health, functionality, and symptomatology at baseline, 1-month, 6-months, 12-months, and 24-months after PB-IORT. Scores were on a 100-point scale with change greater than 10 considered clinically significant. Scores at interval follow-up were compared to baseline using repeated measure modeling with an unstructured covariance matrix.
Results: The cohort consisted of 303 patients, a majority of which were White (84.2%) with a median age of 64 years (IQR: 52, 76). One month after PB-IORT, a decline from baseline in physical (-2.5, 95% CI: -4.4 - -0.55, p = 0.01), role (-7.6, 95% CI: -11.7 - -3.5, p < 0.001), and social functioning (-3.0, 95% CI: -5.5 - -0.42, p = 0.02) were observed, which correlated with increased fatigue (8.4, 95% CI: 5.5-11.3, p < 0.001). At 6 months, nearly all QOL measures returned to baseline or improved. There were no statistically or clinically significant differences from baseline in overall global health. All functional and symptom scale differences were less than 10, indicating minimal clinical significance.
Conclusions: PB-IORT has minimal negative impact on QOL, further supporting this patient-centered treatment approach for early-stage breast cancer.
(Copyright © 2021 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R01 CA214594 United States CA NCI NIH HHS; T32 CA163177 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: Brachytherapy; Breast cancer; Intraoperative radiation therapy; Quality of life
تواريخ الأحداث: Date Created: 20220205 Date Completed: 20220531 Latest Revision: 20230502
رمز التحديث: 20230502
مُعرف محوري في PubMed: PMC9149037
DOI: 10.1016/j.brachy.2021.12.002
PMID: 35120862
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-1449
DOI:10.1016/j.brachy.2021.12.002