دورية أكاديمية
Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain.
العنوان: | Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain. |
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المؤلفون: | Dai J; Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. jdai@fredhutch.org., Cimino PJ; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA., Gouin KH 3rd; Department of Biomedical Sciences; Applied Genomics, Computation and Translational Core, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Grzelak CA; Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Barrett A; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Lim AR; Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, WA, USA., Long A; Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Weaver S; Experimental Histopathology Core, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Saldin LT; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Uzamere A; Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Schulte V; Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Clegg N; Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Pisarsky L; Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Lyden D; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Bissell MJ; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Knott S; Department of Biomedical Sciences; Applied Genomics, Computation and Translational Core, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Welm AL; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Bielas JH; Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Hansen KC; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Winkler F; Neurology Clinic and National Center for Tumour Diseases, University Hospital Heidelberg, DKTK & Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany., Holland EC; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Ghajar CM; Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. cghajar@fredhutch.org.; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. cghajar@fredhutch.org. |
المصدر: | Nature cancer [Nat Cancer] 2022 Jan; Vol. 3 (1), pp. 25-42. Date of Electronic Publication: 2021 Dec 24. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : Nature Publishing Group, [2020]- |
مواضيع طبية MeSH: | Brain Neoplasms* , Breast Neoplasms*/drug therapy, Astrocytes/metabolism ; Brain/metabolism ; Female ; Humans ; Laminin/metabolism ; Tumor Microenvironment |
مستخلص: | Although dormancy is thought to play a key role in the metastasis of breast tumor cells to the brain, our knowledge of the molecular mechanisms regulating disseminated tumor cell (DTC) dormancy in this organ is limited. Here using serial intravital imaging of dormant and metastatic triple-negative breast cancer lines, we identify escape from the single-cell or micrometastatic state as the rate-limiting step towards brain metastasis. We show that every DTC occupies a vascular niche, with quiescent DTCs residing on astrocyte endfeet. At these sites, astrocyte-deposited laminin-211 drives DTC quiescence by inducing the dystroglycan receptor to associate with yes-associated protein, thereby sequestering it from the nucleus and preventing its prometastatic functions. These findings identify a brain-specific mechanism of DTC dormancy and highlight the need for a more thorough understanding of tumor dormancy to develop therapeutic approaches that prevent brain metastasis. (© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.) |
التعليقات: | Comment in: Nat Cancer. 2022 Jan;3(1):3-5. (PMID: 35121997) |
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معلومات مُعتمدة: | P30 CA015704 United States CA NCI NIH HHS; R01 CA252874 United States CA NCI NIH HHS; S10 OD021641 United States OD NIH HHS; P50 AG005136 United States AG NIA NIH HHS; U01 AG006781 United States AG NIA NIH HHS; U54 CA193461 United States CA NCI NIH HHS; F99 CA234840 United States CA NCI NIH HHS; R01 CA064786 United States CA NCI NIH HHS; P50 NS062684 United States NS NINDS NIH HHS; P30 AG066509 United States AG NIA NIH HHS |
المشرفين على المادة: | 0 (Laminin) |
تواريخ الأحداث: | Date Created: 20220205 Date Completed: 20220419 Latest Revision: 20230615 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC9469899 |
DOI: | 10.1038/s43018-021-00297-3 |
PMID: | 35121993 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2662-1347 |
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DOI: | 10.1038/s43018-021-00297-3 |