Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration.

التفاصيل البيبلوغرافية
العنوان:	Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration.
المؤلفون:	McDowell SAC; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.; Department of Physiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Luo RBE; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Arabzadeh A; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada., Doré S; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Bennett NC; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.; Department of Physiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Breton V; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada., Karimi E; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada., Rezanejad M; Departments of Psychology and Computer Science, University of Toronto, Toronto, Ontario, Canada., Yang RR; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.; Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada., Lach KD; Department of Pathology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Issac MSM; Department of Pathology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Samborska B; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada., Perus LJM; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.; Department of Physiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Moldoveanu D; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, McGill University, Montreal, Quebec, Canada., Wei Y; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada., Fiset B; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada., Rayes RF; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada., Watson IR; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, McGill University, Montreal, Quebec, Canada., Kazak L; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.; Department of Biochemistry, McGill University, Montreal, Quebec, Canada., Guiot MC; Department of Pathology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.; Montreal Neurological Institute, McGill University Health Centre, Montreal, Quebec, Canada., Fiset PO; Department of Pathology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada., Spicer JD; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada.; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada.; Department of Surgery, McGill University Health Centre, Montreal, Quebec, Canada., Dannenberg AJ; Department of Medicine, Weill Cornell Medical College, New York, New York, USA., Walsh LA; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada. logan.walsh@mcgill.ca.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada. logan.walsh@mcgill.ca., Quail DF; Rosalind and Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada. daniela.quail@mcgill.ca.; Department of Physiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. daniela.quail@mcgill.ca.; Department of Medicine, Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada. daniela.quail@mcgill.ca.
المصدر:	Nature cancer [Nat Cancer] 2021 May; Vol. 2 (5), pp. 545-562. Date of Electronic Publication: 2021 May 03.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: [London] : Nature Publishing Group, [2020]-
مواضيع طبية MeSH:	Breast Neoplasms/metabolism , Lung Neoplasms/metabolism, Animals ; Catalase/metabolism ; Female ; Humans ; Mice ; Neutrophils/metabolism ; Obesity/complications ; Oxidative Stress
مستخلص:	Metastasis is the leading cause of cancer-related deaths, and obesity is associated with increased breast cancer (BC) metastasis. Preclinical studies have shown that obese adipose tissue induces lung neutrophilia associated with enhanced BC metastasis to this site. Here we show that obesity leads to neutrophil-dependent impairment of vascular integrity through loss of endothelial adhesions, enabling cancer cell extravasation into the lung. Mechanistically, neutrophil-produced reactive oxygen species in obese mice increase neutrophil extracellular DNA traps (NETs) and weaken endothelial junctions, facilitating the influx of tumor cells from the peripheral circulation. In vivo treatment with catalase, NET inhibitors or genetic deletion of Nos2 reversed this effect in preclinical models of obesity. Imaging mass cytometry of lung metastasis samples from patients with cancer revealed an enrichment in neutrophils with low catalase levels correlating with elevated body mass index. Our data provide insights into potentially targetable mechanisms that underlie the progression of BC in the obese population. (© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.)
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معلومات مُعتمدة:	PJT-159742 Canada CIHR; PJT-162137 Canada CIHR
المشرفين على المادة:	EC 1.11.1.6 (Catalase)
تواريخ الأحداث:	Date Created: 20220205 Date Completed: 20220419 Latest Revision: 20221027
رمز التحديث:	20221213
DOI:	10.1038/s43018-021-00194-9
PMID:	35122017
قاعدة البيانات:	MEDLINE

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تدمد:	2662-1347
DOI:	10.1038/s43018-021-00194-9