دورية أكاديمية
Emerging Trends in Mesenchymal Stem Cells Applications for Cardiac Regenerative Therapy: Current Status and Advances.
| العنوان: | Emerging Trends in Mesenchymal Stem Cells Applications for Cardiac Regenerative Therapy: Current Status and Advances. |
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| المؤلفون: | Sharma A; Stem Cell and Molecular Biology Laboratory, Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, Indian Institute of Technology-Madras, Chennai, 600036, Tamil Nadu, India., Gupta S; Stem Cell and Molecular Biology Laboratory, Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, Indian Institute of Technology-Madras, Chennai, 600036, Tamil Nadu, India., Archana S; Stem Cell and Molecular Biology Laboratory, Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, Indian Institute of Technology-Madras, Chennai, 600036, Tamil Nadu, India., Verma RS; Stem Cell and Molecular Biology Laboratory, Bhupat and Jyoti Mehta School of Biosciences, Department of Biotechnology, Indian Institute of Technology-Madras, Chennai, 600036, Tamil Nadu, India. vermars@iitm.ac.in. |
| المصدر: | Stem cell reviews and reports [Stem Cell Rev Rep] 2022 Jun; Vol. 18 (5), pp. 1546-1602. Date of Electronic Publication: 2022 Feb 04. |
| نوع المنشور: | Journal Article; Review; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Science+Business Media Country of Publication: United States NLM ID: 101752767 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2629-3277 (Electronic) Linking ISSN: 26293277 NLM ISO Abbreviation: Stem Cell Rev Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2011- : [New York, NY] : Springer Science+Business Media Original Publication: [Totowa, N.J.] : Humana Press, [2009]- |
| مواضيع طبية MeSH: | Mesenchymal Stem Cell Transplantation* , Mesenchymal Stem Cells* , Myocardial Infarction*/therapy, Humans ; Myocytes, Cardiac ; Regenerative Medicine |
| مستخلص: | Irreversible myocardium infarction is one of the leading causes of cardiovascular disease (CVD) related death and its quantum is expected to grow in coming years. Pharmacological intervention has been at the forefront to ameliorate injury-related morbidity and mortality. However, its outcomes are highly skewed. As an alternative, stem cell-based tissue engineering/regenerative medicine has been explored quite extensively to regenerate the damaged myocardium. The therapeutic modality that has been most widely studied both preclinically and clinically is based on adult multipotent mesenchymal stem cells (MSC) delivered to the injured heart. However, there is debate over the mechanistic therapeutic role of MSC in generating functional beating cardiomyocytes. This review intends to emphasize the role and use of MSC in cardiac regenerative therapy (CRT). We have elucidated in detail, the various aspects related to the history and progress of MSC use in cardiac tissue engineering and its multiple strategies to drive cardiomyogenesis. We have further discussed with a focus on the various therapeutic mechanism uncovered in recent times that has a significant role in ameliorating heart-related problems. We reviewed recent and advanced technologies using MSC to develop/create tissue construct for use in cardiac regenerative therapy. Finally, we have provided the latest update on the usage of MSC in clinical trials and discussed the outcome of such studies in realizing the full potential of MSC use in clinical management of cardiac injury as a cellular therapy module. (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Advanced engineering technologies; Cardiac regenerative therapy; Differentiation; Mesenchymal stem cells; Paracrine activity; Therapeutic role |
| تواريخ الأحداث: | Date Created: 20220205 Date Completed: 20220622 Latest Revision: 20220630 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1007/s12015-021-10314-8 |
| PMID: | 35122226 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2629-3277 |
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| DOI: | 10.1007/s12015-021-10314-8 |