دورية أكاديمية
أعرض في EDS

Acute/Chronic Responses of Combined Training on Serum Pro-thermogenic/Anti-inflammatory Inducers and Its Relation With Fed and Fasting State in Overweight Type 2 Diabetic Individuals.

التفاصيل البيبلوغرافية
العنوان: Acute/Chronic Responses of Combined Training on Serum Pro-thermogenic/Anti-inflammatory Inducers and Its Relation With Fed and Fasting State in Overweight Type 2 Diabetic Individuals.
المؤلفون: Bonfante ILP; Laboratory of Exercise Physiology, Faculty of Physical Education, University of Campinas, Campinas, Brazil.; Federal Institute of Education, Science and Technology of São Paulo, Hortolândia Campus, Hortolândia, Brazil., Duft RG; Laboratory of Exercise Physiology, Faculty of Physical Education, University of Campinas, Campinas, Brazil., Mateus KCDS; Laboratory of Exercise Physiology, Faculty of Physical Education, University of Campinas, Campinas, Brazil., Trombeta JCDS; Laboratory of Exercise Physiology, Faculty of Physical Education, University of Campinas, Campinas, Brazil., Finardi EAR; Laboratory of Exercise Physiology, Faculty of Physical Education, University of Campinas, Campinas, Brazil., Ramkrapes APB; Laboratory of Exercise Physiology, Faculty of Physical Education, University of Campinas, Campinas, Brazil., Brunelli DT; Laboratory of Exercise Physiology, Faculty of Physical Education, University of Campinas, Campinas, Brazil., Mori MADS; Laboratory of Aging Biology, Department of Biochemistry and Tissue Biology, University of Campinas, Campinas, Brazil.; Obesity and Comorbidities Research Center, University of Campinas, Campinas, Brazil., Chacon-Mikahil MPT; Laboratory of Exercise Physiology, Faculty of Physical Education, University of Campinas, Campinas, Brazil., Velloso LA; Obesity and Comorbidities Research Center, University of Campinas, Campinas, Brazil.; Laboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil., Cavaglieri CR; Laboratory of Exercise Physiology, Faculty of Physical Education, University of Campinas, Campinas, Brazil.
المصدر: Frontiers in physiology [Front Physiol] 2022 Jan 20; Vol. 12, pp. 736244. Date of Electronic Publication: 2022 Jan 20 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: Concentrations of pro-thermogenic/anti-inflammatory inductors are influenced by fed/fasting, sedentary/trained states, and metabolic pattern. However, there is a lack of information on the interactions of these conditions, especially in humans. Thus, the present study aimed to evaluate the chronic and acute training responses as well as the fed/fasted states of serum pro-thermogenic/anti-inflammatory inducers in overweight type 2 diabetics individuals. Fifteen individuals with type 2 diabetes [body mass index (BMI): 29.61 ± 3.60 kg/m 2 ; age: 50.67 ± 3.97 years] participated in the study. In the pre- and post-experimental periods, baseline clinical parameters analyses were performed. Pro-thermogenic/anti-inflammatory inductors were evaluated pre/post-baseline and before, shortly after, and after 30' and 60' in the first and last sessions of a 16-week combined training (CT) period. These inducers were also compared for fasting and feeding before and after the training period. CT has improved baseline physical fitness, metabolic pattern, and it has also increased interleukin (IL)33 and FNDC5/irisin. In the first training session, there was a decrease in IL4, IL13, and IL33, besides an increase in FNDC5/irisin, and natriuretic peptides. In the last training session, there was an increase in natriuretic peptides and bone morphogenic protein 4 (BMP4). Differences in responses between the first and last training sessions were observed at certain post-session times for IL4, IL33, and natriuretic peptides, always with higher concentrations occurring in the last session. In evaluating the area under the curve (AUC) of the first and last training session, FNDC5/irisin, natriuretics peptides, and meteorin-like showed increased areas in the last training session. The pre-training fed state showed an increase in IL4 and IL33, while in fasting there was an increase in meteorin-like, natriuretic peptides, and FNDC5/irisin. In the post-training, IL4, IL13, and IL33 were increased in the fed state, while meteorin-like, natriuretic peptides, and FNDC5/irisin remained increased in the fast. Adaptation to physical training and a better metabolic pattern favor an improvement in the acute secretory pattern in part of pro-thermogenic and anti-inflammatory substances analyzed. The fed and fasting states also interfere differently in these substances, where fasting interferes with the increase of myokines, while the fed state induces an increase in interleukins. Clinical Trial Registration: [http://www.ensaiosclinicos.gov.br/rg/RBR-62n5qn/], identifier [U1111-1202-1476].
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Bonfante, Duft, Mateus, Trombeta, Finardi, Ramkrapes, Brunelli, Mori, Chacon-Mikahil, Velloso and Cavaglieri.)
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فهرسة مساهمة: Keywords: brown adipose tissue (BAT); browning of white adipose tissue (WAT); inflammation; interleukins; metabolism; myokines; type 2 diabetes
تواريخ الأحداث: Date Created: 20220207 Latest Revision: 20220208
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8811167
DOI: 10.3389/fphys.2021.736244
PMID: 35126168
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-042X
DOI:10.3389/fphys.2021.736244