دورية أكاديمية
أعرض في EDS

Association of gut-related metabolites with respiratory symptoms in COVID-19: A proof-of-concept study.

التفاصيل البيبلوغرافية
العنوان: Association of gut-related metabolites with respiratory symptoms in COVID-19: A proof-of-concept study.
المؤلفون: Israr MZ; Department of Cardiovascular Sciences, University of Leicester, Leicester, National Institute for Health Research Leicester Biomedical Research Centre, Leicester, United Kingdom., Ibrahim W; Department of Infection, Immunity and Inflammation, Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom., Salzano A; IRCCS SDN, Diagnostic and Nuclear Research Institute, Napoli, Italy., Sarmad S; Department of Cardiovascular Sciences, University of Leicester, Leicester, National Institute for Health Research Leicester Biomedical Research Centre, Leicester, United Kingdom., Wilde MJ; School of Chemistry, University of Leicester, Leicester, United Kingdom., Cordell RL; School of Chemistry, University of Leicester, Leicester, United Kingdom., Greening NJ; Department of Infection, Immunity and Inflammation, Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom., Brightling CE; Department of Infection, Immunity and Inflammation, Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom., Siddiqui S; Department of Infection, Immunity and Inflammation, Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, United Kingdom., Suzuki T; Department of Cardiovascular Sciences, University of Leicester, Leicester, National Institute for Health Research Leicester Biomedical Research Centre, Leicester, United Kingdom; The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Electronic address: ts263@le.ac.uk.
مؤلفون مشاركون: EMBER consortium
المصدر: Nutrition (Burbank, Los Angeles County, Calif.) [Nutrition] 2022 Apr; Vol. 96, pp. 111585. Date of Electronic Publication: 2022 Jan 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8802712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1244 (Electronic) Linking ISSN: 08999007 NLM ISO Abbreviation: Nutrition Subsets: MEDLINE
أسماء مطبوعة: Publication: Tarrytown, NY : Elsevier Science
Original Publication: [Burbank, Calif. : Nutrition, c1987-
مواضيع طبية MeSH: COVID-19*/complications , Gastrointestinal Microbiome*, Betaine ; Carnitine ; Choline ; Humans ; Methylamines/metabolism
مستخلص: Gut-related metabolites have been linked with respiratory disease. The crosstalk between the gut and lungs suggests that gut health may be compromised in COVID-19. The aims of the present study were to analyze a panel of gut-related metabolites (acetyl-L-carnitine, betaine, choline, L-carnitine, trimethylamine, and trimethylamine N-oxide) in patients with COVID-19, matched with healthy individuals and patients with non-COVID-19 respiratory symptoms. As results, metabolites from this panel were impaired in patients with COVID-19 and were associated with the symptoms of breathlessness and temperature, and it was possible to differentiate between COVID-19 and asthma. Preliminary results showed that lower levels of betaine appeared to be associated with poor outcomes in patients with COVID-19, suggesting betaine as a marker of gut microbiome health.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
References: Am Heart J. 2021 Apr;234:71-80. (PMID: 33454370)
Metabolites. 2020 Mar 06;10(3):. (PMID: 32155960)
J Immunol Res. 2020 Jul 31;2020:2340670. (PMID: 32802893)
Eur Arch Otorhinolaryngol. 2017 Feb;274(2):617-626. (PMID: 27115907)
Nat Rev Microbiol. 2017 Jan;15(1):55-63. (PMID: 27694885)
Immunobiology. 2010 Jul;215(7):527-34. (PMID: 19897276)
Nutrition. 2020 Nov - Dec;79-80:110996. (PMID: 33002653)
Nat Rev Immunol. 2020 Jun;20(6):363-374. (PMID: 32346093)
J Breath Res. 2018 Sep 27;12(4):046015. (PMID: 30168442)
J Dig Dis. 2020 Mar;21(3):125-126. (PMID: 32096611)
Heart Fail Clin. 2020 Jan;16(1):23-31. (PMID: 31735312)
Front Cell Infect Microbiol. 2020 Feb 19;10:9. (PMID: 32140452)
Ann Am Thorac Soc. 2015 Nov;12 Suppl 2:S150-6. (PMID: 26595731)
معلومات مُعتمدة: MC_PC_16051 United Kingdom MRC_ Medical Research Council; MR/N005880/1 United Kingdom MRC_ Medical Research Council
فهرسة مساهمة: Keywords: COVID-19; Gut microbiota; Metabolomics; Respiratory
المشرفين على المادة: 0 (Methylamines)
3SCV180C9W (Betaine)
N91BDP6H0X (Choline)
S7UI8SM58A (Carnitine)
تواريخ الأحداث: Date Created: 20220208 Date Completed: 20220317 Latest Revision: 20240214
رمز التحديث: 20240214
مُعرف محوري في PubMed: PMC8730784
DOI: 10.1016/j.nut.2021.111585
PMID: 35131599
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-1244
DOI:10.1016/j.nut.2021.111585