دورية أكاديمية
Synthesis, characterization and antiproliferative effects of naphtho [2,3- b ] thiophen-4,9-quinone on bladder tumor cells.
| العنوان: | Synthesis, characterization and antiproliferative effects of naphtho [2,3- b ] thiophen-4,9-quinone on bladder tumor cells. |
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| المؤلفون: | Ferreira GM; Programa de Pós-graduação em Ciências Farmacêuticas (CIPHARMA), Universidade Federal de Ouro Preto, Ouro Preto, Brazil., Lima APB; Programa de Pós-graduação em Ciências Farmacêuticas (CIPHARMA), Universidade Federal de Ouro Preto, Ouro Preto, Brazil., Pereira GR; Departamento de Física e Química Instituto de Ciências Exatas e Informática ICEI, Pontifícia Universidade Católica de Minas Gerais, PUC Minas, Belo Horizonte, Brazil., Silva GND; Programa de Pós-graduação em Ciências Farmacêuticas (CIPHARMA), Universidade Federal de Ouro Preto, Ouro Preto, Brazil., Brandão GC; Programa de Pós-graduação em Ciências Farmacêuticas (CIPHARMA), Universidade Federal de Ouro Preto, Ouro Preto, Brazil. |
| المصدر: | Natural product research [Nat Prod Res] 2023 Jul; Vol. 37 (13), pp. 2285-2292. Date of Electronic Publication: 2022 Feb 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Antineoplastic Agents*/chemistry , Urinary Bladder Neoplasms*/drug therapy , Naphthoquinones*/pharmacology , Naphthoquinones*/chemistry, Humans ; Urinary Bladder/metabolism ; Thiophenes ; Reactive Oxygen Species/metabolism ; Cell Proliferation ; Cell Line, Tumor ; Apoptosis ; Drug Screening Assays, Antitumor |
| مستخلص: | Naphthoquinones are natural plants products or synthesized compounds. They have α, β-cyclic aromatic dienones structure with a naphthalene skeleton. Little is known about naphthoquinone and nothing about naphtho [2,3-b] thiophen-4,9-quinone effects on bladder cancer. In this study, a naphthoquinone containing a hetero sulfur atom was synthesized using classical synthetic method. The molecular structure was elucidated by NMR techniques and the antitumor effects were evaluated on bladder tumor cell lines with different TP53 status using tripan blue and MTT cytotoxic method, quantification of reactive oxygen species (ROS), wound healing, cell morphology and cell cycle progression assays. The results showed selective cytotoxicity, colonies reduction, morphological change, inhibition of the cell migration process, induction of ROS production and cell cycle arrest. Naphtho [2,3- b ] thiophen-4,9-quinone presents antiproliferative activity regardless TP53 status and may be a promising agent in the treatment of bladder cancer, as they have an oxidizing effect and interfere with cell cycle. |
| فهرسة مساهمة: | Keywords: Bladder cancer; cell death; naphthoquinone; oxidative stress; quinone |
| المشرفين على المادة: | 0 (Thiophenes) 0 (Reactive Oxygen Species) 0 (Antineoplastic Agents) 0 (Naphthoquinones) |
| تواريخ الأحداث: | Date Created: 20220208 Date Completed: 20230620 Latest Revision: 20230620 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/14786419.2022.2036143 |
| PMID: | 35133203 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2022.2036143 |