دورية أكاديمية
A specific esterase and pH logically regulate ESIPT: different kinds of granulocyte sorting.
| العنوان: | A specific esterase and pH logically regulate ESIPT: different kinds of granulocyte sorting. |
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| المؤلفون: | Wang K; Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering Institution, Henan Normal University, Xinxiang 453007, China. zhanghua1106@163.com., Feng B; Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering Institution, Henan Normal University, Xinxiang 453007, China. zhanghua1106@163.com., Wang G; School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453007, China., Cui J; Henan Key Laboratory of Medical Polymer Materials Technology and Application, Xinxiang 453007, China., Yang L; Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering Institution, Henan Normal University, Xinxiang 453007, China. zhanghua1106@163.com., Jiang K; Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering Institution, Henan Normal University, Xinxiang 453007, China. zhanghua1106@163.com., Zhang H; Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering Institution, Henan Normal University, Xinxiang 453007, China. zhanghua1106@163.com. |
| المصدر: | Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2022 Feb 24; Vol. 58 (17), pp. 2894-2897. Date of Electronic Publication: 2022 Feb 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Protons*, Granulocytes/*metabolism , Naphthol AS D Esterase/*metabolism, Fluorescent Dyes/chemical synthesis ; Fluorescent Dyes/chemistry ; Granulocytes/chemistry ; Humans ; Hydrogen-Ion Concentration ; Molecular Structure ; Naphthol AS D Esterase/analysis |
| مستخلص: | Simultaneously detecting naphthol AS-D chloroacetate esterase (NAS-DCE) and pH is an effective way to separate different granulocytes, which is of great significance for the analysis of blood. A series of fluorescent small molecules (HBT-ASDs) were designed, whose ESIPT process could be logically regulated by NAS-DCE and pH. One typical molecule, HBT-ASD-2, emits three kinds of fluorescence output signal at 438 nm and 545 nm for NAS-DCE under different pH values (5.0, 7.4 and 10, respectively). According to such differential signals, the acid, neutrophil and alkaline granulocytes can be sorted, and the activity of NAS-DCE can also be simultaneously monitored in real-time. Thus, a simple analytical tool for clinical blood monitoring and analysis is provided. |
| المشرفين على المادة: | 0 (Fluorescent Dyes) 0 (Protons) EC 3.1.- (Naphthol AS D Esterase) |
| تواريخ الأحداث: | Date Created: 20220208 Date Completed: 20220301 Latest Revision: 20220301 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1039/d1cc07261g |
| PMID: | 35133360 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1364-548X |
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| DOI: | 10.1039/d1cc07261g |