دورية أكاديمية
Evaluation of robustly optimised intensity modulated proton therapy for nasopharyngeal carcinoma.
| العنوان: | Evaluation of robustly optimised intensity modulated proton therapy for nasopharyngeal carcinoma. |
|---|---|
| المؤلفون: | Scandurra D; University of Groningen, University Medical Centre Groningen, Department of Radiation Oncology, The Netherlands. Electronic address: d.scandurra@umcg.nl., Meijer TWH; University of Groningen, University Medical Centre Groningen, Department of Radiation Oncology, The Netherlands., Free J; University of Groningen, University Medical Centre Groningen, Department of Radiation Oncology, The Netherlands., van den Hoek JGM; University of Groningen, University Medical Centre Groningen, Department of Radiation Oncology, The Netherlands., Kelder L; University of Groningen, University Medical Centre Groningen, Department of Radiation Oncology, The Netherlands., Oldehinkel E; University of Groningen, University Medical Centre Groningen, Department of Radiation Oncology, The Netherlands., Steenbakkers RJHM; University of Groningen, University Medical Centre Groningen, Department of Radiation Oncology, The Netherlands., Both S; University of Groningen, University Medical Centre Groningen, Department of Radiation Oncology, The Netherlands., Langendijk JA; University of Groningen, University Medical Centre Groningen, Department of Radiation Oncology, The Netherlands. |
| المصدر: | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2022 Mar; Vol. 168, pp. 221-228. Date of Electronic Publication: 2022 Feb 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8407192 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0887 (Electronic) Linking ISSN: 01678140 NLM ISO Abbreviation: Radiother Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Scientific Publishers Original Publication: Amsterdam : Elsevier Science Publishers, c1983- |
| مواضيع طبية MeSH: | Nasopharyngeal Neoplasms*/diagnostic imaging , Nasopharyngeal Neoplasms*/radiotherapy , Proton Therapy*/methods , Radiotherapy, Intensity-Modulated*/methods, Humans ; Nasopharyngeal Carcinoma/radiotherapy ; Organs at Risk ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods |
| مستخلص: | Background and Purpose: To evaluate the dosimetric changes occurring over the treatment course for nasopharyngeal carcinoma (NPC) patients treated with robustly optimised intensity modulated proton therapy (IMPT). Materials and Methods: 25 NPC patients were treated to two dose levels (CTV1: 70 Gy, CTV2: 54.25 Gy) with robustly optimised IMPT plans. Robustness evaluation was performed over 28 error scenarios using voxel-wise minimum distributions to assess target coverage and voxel-wise maximum distributions to assess possible hotspots and critical organ doses. Daily CBCT was used for positioning and weekly repeat CTs (rCT) were taken, on which the plan dose was recalculated and robustly evaluated. Deformable image registration was used to warp and accumulate the nominal, voxel-wise minimum and maximum rCT dose distributions. Changes to target coverage, critical organ and normal tissue dose between the accumulated and planned doses were investigated. Results: 2 patients required a plan adaptation due to reduced target coverage. The D98% in the accumulated voxel-wise minimum distribution was higher than planned for CTV1 in 24/25 patients and for CTV2 in 20/25 patients. Maximum doses to the critical organs remained acceptable in all patients. Other normal tissue doses showed some variation as a result of soft tissue deformations and weight change. Normal tissue complication probabilities for grade ≥ 2 dysphagia and grade ≥ 2 xerostomia remained similar to planned values. Conclusion: Robustly optimised IMPT plans, in combination with volumetric verification imaging and adaptive planning, provided robust target coverage and acceptable OAR dose variation in our NPC cohort when accumulated over longitudinal data. Competing Interests: Conflict of Interest None. (Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Head and neck; IMPT; Nasopharyngeal cancer; Proton therapy; Robust optimisation |
| تواريخ الأحداث: | Date Created: 20220208 Date Completed: 20220407 Latest Revision: 20220526 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.radonc.2022.01.043 |
| PMID: | 35134448 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1879-0887 |
|---|---|
| DOI: | 10.1016/j.radonc.2022.01.043 |