دورية أكاديمية
أعرض في EDS

Cardiopulmonary exercise test in patients with refractory angina: functional and ischemic evaluation.

التفاصيل البيبلوغرافية
العنوان: Cardiopulmonary exercise test in patients with refractory angina: functional and ischemic evaluation.
المؤلفون: de Assumpção CRA; Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil., do Prado DML; ULTRA Exercise Physiology Laboratory, São Paulo, SP, Brazil., Jordão CP; Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil., Dourado LOC; Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil., Vieira MLC; Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil., Montenegro CGSP; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Negrão CE; Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil; Escola de Educação Fisica e Esporte, Universidade de São Paulo, São Paulo, SP, Brazil., Gowdak LHW; Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil., De Matos LDNJ; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil. Electronic address: luciana.matos@einstein.br.
المصدر: Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2022 Feb 05; Vol. 77, pp. 100003. Date of Electronic Publication: 2022 Feb 05 (Print Publication: 2022).
نوع المنشور: Clinical Study; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101244734 Publication Model: eCollection Cited Medium: Internet ISSN: 1980-5322 (Electronic) Linking ISSN: 18075932 NLM ISO Abbreviation: Clinics (Sao Paulo) Subsets: MEDLINE
أسماء مطبوعة: Publication: 2022- : [New York] : Elsevier
Original Publication: São Paulo, SP : Hospital das Clínicas, Faculty of Medicine, University of São Paulo, [2005]-
مواضيع طبية MeSH: Exercise Test* , Myocardial Ischemia*/diagnosis, Canada ; Exercise Tolerance ; Female ; Humans ; Ischemia ; Male ; Oxygen Consumption
مستخلص: Objectives: Refractory angina (RA) is a chronic condition clinically characterized by low effort tolerance; therefore, physical stress testing is not usually requested for these patients. Cardiopulmonary exercise testing (CPET) is considered a gold standard examination for functional capacity evaluation, even in submaximal tests, and it has gained great prominence in detecting ischemia. The authors aimed to determine cardiorespiratory capacity by using the oxygen consumption efficiency slope (OUES) in patients with refractory angina. The authors also studied the O 2 pulse response by CPET and the association of ischemic changes with contractile modifications by exercise stress echocardiography (ESE).
Methods: Thirty-one patients of both sexes, aged 45 to 75 years, with symptomatic (Canadian Cardiovascular Society class II to IV) angina who underwent CPET on a treadmill and exercise stress echocardiography on a lower limb cycle ergometer were studied. ClinicalTrials.gov: NCT03218891.
Results: The patients had low cardiorespiratory capacity (OUES of 1.74 ± 0.4 L/min; 63.9±14.7% of predicted), and 77% of patients had a flattening or drop in O 2 pulse response. There was a direct association between Heart Rate (HR) at the onset of myocardial ischemia detected by ESE and HR at the onset of flattening or drop in oxygen pulse response detected by CPET (R = 0.48; p = 0.019).
Conclusion: Patients with refractory angina demonstrate low cardiorespiratory capacity. CPET shows good sensitivity for detecting abnormal cardiovascular response in these patients with a significant relationship between flattening O 2 pulse response during CEPT and contractile alterations detected by exercise stress echocardiography.
Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest.
(Copyright © 2021. Published by Elsevier España, S.L.U.)
فهرسة مساهمة: Keywords: Cardiopulmonary exercise testing; Exercise capacity; Myocardial ischemia; Oxygen pulse; Oxygen uptake efficiency slope
سلسلة جزيئية: ClinicalTrials.gov NCT03218891
تواريخ الأحداث: Date Created: 20220208 Date Completed: 20220421 Latest Revision: 20220531
رمز التحديث: 20240628
DOI: 10.1016/j.clinsp.2021.100003
PMID: 35134662
قاعدة البيانات: MEDLINE
الوصف
تدمد:1980-5322
DOI:10.1016/j.clinsp.2021.100003