دورية أكاديمية
Dissecting Fc signatures of protection in neonates following maternal influenza vaccination in a placebo-controlled trial.
العنوان: | Dissecting Fc signatures of protection in neonates following maternal influenza vaccination in a placebo-controlled trial. |
---|---|
المؤلفون: | Boudreau CM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; PhD Program in Virology, Harvard University, Cambridge, MA, USA., Burke JS 4th; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Shuey KD; Department of Medicine, University of Washington, Seattle, WA, USA., Wolf C; Department of Medicine, University of Washington, Seattle, WA, USA., Katz J; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Tielsch J; Department of Global Health, Milken Institute School of Public Health, George Washington University, Washington, DC, USA., Khatry S; Nepal Nutrition Intervention Project, Sarlahi, Kathmandu, Nepal., LeClerq SC; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Nepal Nutrition Intervention Project, Sarlahi, Kathmandu, Nepal., Englund JA; Department of Pediatrics, Seattle Children's Research Institute and University of Washington, Seattle, WA, USA. Electronic address: janet.englund@seattlechildrens.org., Chu HY; Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address: helenchu@uw.edu., Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA. Electronic address: galter@mgh.harvard.edu. |
المصدر: | Cell reports [Cell Rep] 2022 Feb 08; Vol. 38 (6), pp. 110337. |
نوع المنشور: | Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, c 2012- |
مواضيع طبية MeSH: | Vaccination*/methods, Antibodies, Viral/*immunology , Influenza Vaccines/*immunology , Influenza, Human/*immunology, Female ; Humans ; Infant ; Infant, Newborn ; Influenza, Human/prevention & control ; Placebos ; Pregnancy |
مستخلص: | Influenza is an important cause of illness and morbidity for infants. Seasonal influenza vaccination during pregnancy aims to provide protection to mothers, but it can also provide immunity to infants. The precise influence of maternal vaccination on immunity in infants and how vaccine-elicited antibodies provide protection in some but not all infants is incompletely understood. We comprehensively profiled the transfer of functional antibodies and defined humoral factors contributing to immunity against influenza in a clinical trial of maternal influenza vaccination. Influenza-specific antibody subclass levels, Fc ɣ receptor (FCGR) binding levels, and antibody-dependent innate immune functions were all profiled in the mothers during pregnancy and at birth, as well as in cord blood. Vaccination increased influenza-specific antibody levels, antibody binding to FCGR, and specific antibody-dependent innate immune functions in both maternal and cord blood, with FCGR binding most enhanced via vaccination. Influenza-specific FCGR binding levels were lower in cord blood of infants who subsequently developed influenza infection. Collectively these data suggest that in addition to increased antibody amounts, the selective transfer of FCGR-binding antibodies contributes to the protective immune response in infants against influenza. Competing Interests: Declaration of interests G.A. is a founder of SeromYx Systems, Inc. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.) |
References: | Lancet HIV. 2018 Nov;5(11):e613-e614. (PMID: 30507441) Nat Commun. 2011 Dec 20;2:599. (PMID: 22186895) Ann Intern Med. 1995 Oct 1;123(7):518-27. (PMID: 7661497) Pediatr Infect Dis J. 2011 Feb;30(2):170-3. (PMID: 20856162) J Immunol Methods. 2012 Dec 14;386(1-2):117-23. (PMID: 23023091) Front Immunol. 2019 Mar 18;10:440. (PMID: 30949165) J Clin Invest. 2020 Feb 3;130(2):662-672. (PMID: 31845904) J Infect Dis. 2017 Dec 27;217(1):12-23. (PMID: 29106590) Lancet Glob Health. 2020 Apr;8(4):e497-e510. (PMID: 32087815) MAbs. 2014 Jul-Aug;6(4):915-27. (PMID: 24927273) BMC Pregnancy Childbirth. 2015 Feb 20;15:40. (PMID: 25879974) BMC Public Health. 2009 Jul 14;9:236. (PMID: 19602255) Lancet Infect Dis. 2017 Sep;17(9):981-989. (PMID: 28522338) Wkly Epidemiol Rec. 2012 Nov 23;87(47):461-76. (PMID: 23210147) Pediatr Int. 2000 Aug;42(4):337-42. (PMID: 10986861) Sci Rep. 2017 Mar 17;7:44727. (PMID: 28303960) Nat Med. 2018 Oct;24(10):1590-1598. (PMID: 30177821) Hum Vaccin Immunother. 2018 Mar 4;14(3):758-766. (PMID: 28708952) Nature. 1989 Jan 12;337(6203):184-7. (PMID: 2911353) J Infect Dis. 2011 Dec 15;204(12):1879-85. (PMID: 21998477) N Engl J Med. 2014 Sep 4;371(10):918-31. (PMID: 25184864) Lancet. 2011 Dec 3;378(9807):1917-30. (PMID: 22078723) Immunol Cell Biol. 2020 Apr;98(4):253-263. (PMID: 31914207) Clin Exp Immunol. 2019 Feb;195(2):139-152. (PMID: 30422307) BMC Infect Dis. 2019 Apr 4;19(1):308. (PMID: 30947693) PLoS One. 2013 Aug 14;8(8):e70867. (PMID: 23967126) J Infect Dis. 2015 Sep 15;212(6):861-70. (PMID: 25740957) J Infect Dis. 2013 Oct 1;208(7):1051-61. (PMID: 23812238) Nat Med. 2002 Apr;8(4):373-8. (PMID: 11927943) Vaccine. 2020 Feb 28;38(10):2368-2377. (PMID: 32035709) J Immunol Methods. 2011 Mar 7;366(1-2):8-19. (PMID: 21192942) Eur J Immunol. 1985 Jul;15(7):733-8. (PMID: 2988974) J Infect Dis. 1993 Sep;168(3):647-56. (PMID: 8354906) Vaccine. 2015 Jul 31;33(32):3801-12. (PMID: 26095508) JAMA. 1994 Dec 7;272(21):1661-5. (PMID: 7966893) Vaccine. 2017 Dec 4;35(48 Pt B):6743-6750. (PMID: 29100709) Nat Med. 2014 Feb;20(2):143-51. (PMID: 24412922) Cell. 2019 Jun 27;178(1):202-215.e14. (PMID: 31204102) Hum Vaccin Immunother. 2017 Jun 3;13(6):1-9. (PMID: 28332900) Pathogens. 2021 Mar 17;10(3):. (PMID: 33802803) J Infect Dis. 2015 Oct 1;212(7):1052-60. (PMID: 25795791) mBio. 2016 Oct 4;7(5):. (PMID: 27703076) Vaccine. 2020 Feb 11;38(7):1601-1613. (PMID: 31932138) J Virol. 2013 May;87(10):5512-22. (PMID: 23468501) PLoS Pathog. 2017 Mar 16;13(3):e1006248. (PMID: 28301559) Vaccine. 2020 Sep 22;38(41):6478-6483. (PMID: 32868130) Vaccines (Basel). 2018 May 17;6(2):. (PMID: 29772781) Braz J Med Biol Res. 1996 Feb;29(2):201-4. (PMID: 8731349) Vaccine. 2011 Jun 15;29(27):4439-52. (PMID: 21550377) Clin Exp Vaccine Res. 2019 Jan;8(1):77-85. (PMID: 30775354) J Clin Invest. 2016 Feb;126(2):605-10. (PMID: 26731473) Clin Infect Dis. 2018 Jul 18;67(3):334-340. (PMID: 29452372) J Immunol Methods. 2019 Aug;471:46-56. (PMID: 31132351) Hum Vaccin Immunother. 2012 Sep;8(9):1218-22. (PMID: 22894961) Cell. 2016 Oct 6;167(2):433-443.e14. (PMID: 27667685) Lancet Infect Dis. 2016 Sep;16(9):1026-1035. (PMID: 27261067) Nat Commun. 2017 Oct 10;8(1):846. (PMID: 29018261) Nutrients. 2019 Jul 11;11(7):. (PMID: 31336756) N Engl J Med. 2008 Oct 9;359(15):1555-64. (PMID: 18799552) Euro Surveill. 2014 Nov 13;19(45):20959. (PMID: 25411687) PLoS One. 2013 Oct 24;8(10):e79040. (PMID: 24205364) J Immunol Methods. 2019 Oct;473:112630. (PMID: 31301278) Cell. 2015 Nov 5;163(4):988-98. (PMID: 26544943) Infect Dis Ther. 2019 Dec;8(4):499-541. (PMID: 31535327) Am J Epidemiol. 1998 Dec 1;148(11):1094-102. (PMID: 9850132) Front Immunol. 2020 Sep 11;11:1920. (PMID: 33013843) PLoS One. 2011 Mar 09;6(3):e17377. (PMID: 21408070) J Infect Chemother. 2015 Apr;21(4):238-46. (PMID: 25708925) N Engl J Med. 2017 Mar 30;376(13):1256-1267. (PMID: 28355514) Blood. 2009 Apr 16;113(16):3716-25. (PMID: 19018092) J Immunol. 2001 Jun 15;166(12):7381-8. (PMID: 11390489) |
معلومات مُعتمدة: | P30 AI060354 United States AI NIAID NIH HHS; R37 AI080289 United States AI NIAID NIH HHS; T32 AI007245 United States AI NIAID NIH HHS |
فهرسة مساهمة: | Keywords: Fc effector function; Fc receptor; adaptive immunity; antibody; influenza; innate immunity; maternal vaccination; placental transfer; vaccination |
المشرفين على المادة: | 0 (Antibodies, Viral) 0 (Influenza Vaccines) 0 (Placebos) |
تواريخ الأحداث: | Date Created: 20220209 Date Completed: 20220224 Latest Revision: 20240214 |
رمز التحديث: | 20240214 |
مُعرف محوري في PubMed: | PMC9026287 |
DOI: | 10.1016/j.celrep.2022.110337 |
PMID: | 35139373 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2211-1247 |
---|---|
DOI: | 10.1016/j.celrep.2022.110337 |