دورية أكاديمية
أعرض في EDS

Dissecting Fc signatures of protection in neonates following maternal influenza vaccination in a placebo-controlled trial.

التفاصيل البيبلوغرافية
العنوان: Dissecting Fc signatures of protection in neonates following maternal influenza vaccination in a placebo-controlled trial.
المؤلفون: Boudreau CM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; PhD Program in Virology, Harvard University, Cambridge, MA, USA., Burke JS 4th; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA., Shuey KD; Department of Medicine, University of Washington, Seattle, WA, USA., Wolf C; Department of Medicine, University of Washington, Seattle, WA, USA., Katz J; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Tielsch J; Department of Global Health, Milken Institute School of Public Health, George Washington University, Washington, DC, USA., Khatry S; Nepal Nutrition Intervention Project, Sarlahi, Kathmandu, Nepal., LeClerq SC; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Nepal Nutrition Intervention Project, Sarlahi, Kathmandu, Nepal., Englund JA; Department of Pediatrics, Seattle Children's Research Institute and University of Washington, Seattle, WA, USA. Electronic address: janet.englund@seattlechildrens.org., Chu HY; Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address: helenchu@uw.edu., Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA. Electronic address: galter@mgh.harvard.edu.
المصدر: Cell reports [Cell Rep] 2022 Feb 08; Vol. 38 (6), pp. 110337.
نوع المنشور: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Vaccination*/methods, Antibodies, Viral/*immunology , Influenza Vaccines/*immunology , Influenza, Human/*immunology, Female ; Humans ; Infant ; Infant, Newborn ; Influenza, Human/prevention & control ; Placebos ; Pregnancy
مستخلص: Influenza is an important cause of illness and morbidity for infants. Seasonal influenza vaccination during pregnancy aims to provide protection to mothers, but it can also provide immunity to infants. The precise influence of maternal vaccination on immunity in infants and how vaccine-elicited antibodies provide protection in some but not all infants is incompletely understood. We comprehensively profiled the transfer of functional antibodies and defined humoral factors contributing to immunity against influenza in a clinical trial of maternal influenza vaccination. Influenza-specific antibody subclass levels, Fc ɣ receptor (FCGR) binding levels, and antibody-dependent innate immune functions were all profiled in the mothers during pregnancy and at birth, as well as in cord blood. Vaccination increased influenza-specific antibody levels, antibody binding to FCGR, and specific antibody-dependent innate immune functions in both maternal and cord blood, with FCGR binding most enhanced via vaccination. Influenza-specific FCGR binding levels were lower in cord blood of infants who subsequently developed influenza infection. Collectively these data suggest that in addition to increased antibody amounts, the selective transfer of FCGR-binding antibodies contributes to the protective immune response in infants against influenza.
Competing Interests: Declaration of interests G.A. is a founder of SeromYx Systems, Inc.
(Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: P30 AI060354 United States AI NIAID NIH HHS; R37 AI080289 United States AI NIAID NIH HHS; T32 AI007245 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Fc effector function; Fc receptor; adaptive immunity; antibody; influenza; innate immunity; maternal vaccination; placental transfer; vaccination
المشرفين على المادة: 0 (Antibodies, Viral)
0 (Influenza Vaccines)
0 (Placebos)
تواريخ الأحداث: Date Created: 20220209 Date Completed: 20220224 Latest Revision: 20240214
رمز التحديث: 20240214
مُعرف محوري في PubMed: PMC9026287
DOI: 10.1016/j.celrep.2022.110337
PMID: 35139373
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2022.110337