دورية أكاديمية
Emerging trends in pulmonary delivery of biopharmaceuticals.
| العنوان: | Emerging trends in pulmonary delivery of biopharmaceuticals. |
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| المؤلفون: | Kunde SS; Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, India., Ghosh R; Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, India., Wairkar S; Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, India. Electronic address: sarikawairkar@gmail.com. |
| المصدر: | Drug discovery today [Drug Discov Today] 2022 May; Vol. 27 (5), pp. 1474-1482. Date of Electronic Publication: 2022 Feb 07. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd. Country of Publication: England NLM ID: 9604391 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5832 (Electronic) Linking ISSN: 13596446 NLM ISO Abbreviation: Drug Discov Today Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kidlington, Oxford : Irvington, NJ : Elsevier Science Ltd. ; Distributed by Virgin Mailing and Distribution, c1996- |
| مواضيع طبية MeSH: | Biological Products*/chemistry, Drug Delivery Systems ; Lung/metabolism ; Peptides/metabolism ; Pharmaceutical Preparations/metabolism |
| مستخلص: | Over the years, a tendency toward biopharmaceutical products as therapeutics has been witnessed compared with small molecular drugs. Biopharmaceuticals possess greater specificity, selectivity and potency with fewer side effects. The pulmonary route is a potential noninvasive route studied for the delivery of various molecules, including biopharmaceuticals. It directly delivers drugs to the lungs in higher concentrations and provides greater bioavailability than other noninvasive routes. This review focuses on the pulmonary route for the delivery of biopharmaceuticals. We have covered various biopharmaceuticals, including peptides, recombinant proteins, enzymes, monoclonal antibodies and nucleic acids, administered via a pulmonary route and discussed their rewards and drawbacks. (Copyright © 2022 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Biopharmaceuticals; Gene delivery; Peptides; Proteins; Pulmonary delivery; siRNA |
| المشرفين على المادة: | 0 (Biological Products) 0 (Peptides) 0 (Pharmaceutical Preparations) |
| تواريخ الأحداث: | Date Created: 20220210 Date Completed: 20220426 Latest Revision: 20220517 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.drudis.2022.02.003 |
| PMID: | 35143963 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-5832 |
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| DOI: | 10.1016/j.drudis.2022.02.003 |