دورية أكاديمية
Eco-Friendly UV Spectrophotometric Method for Evaluation of Marbofloxacin in Tablets: Stability Study.
| العنوان: | Eco-Friendly UV Spectrophotometric Method for Evaluation of Marbofloxacin in Tablets: Stability Study. |
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| المؤلفون: | da Silva TLA; Laboratório de Controle de Qualidade, Faculdade de Farmácia, Universidade Federal de Goiás-UFG, Street 240, Goiânia, Goiás 74605-170, Brazil., Lustosa IA; Laboratório de Controle de Qualidade, Faculdade de Farmácia, Universidade Federal de Goiás-UFG, Street 240, Goiânia, Goiás 74605-170, Brazil., Torres IMS; Laboratório de Controle de Qualidade, Faculdade de Farmácia, Universidade Federal de Goiás-UFG, Street 240, Goiânia, Goiás 74605-170, Brazil., Kogawa AC; Laboratório de Controle de Qualidade, Faculdade de Farmácia, Universidade Federal de Goiás-UFG, Street 240, Goiânia, Goiás 74605-170, Brazil. |
| المصدر: | Journal of AOAC International [J AOAC Int] 2022 Jun 29; Vol. 105 (4), pp. 1017-1022. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9215446 Publication Model: Print Cited Medium: Internet ISSN: 1944-7922 (Electronic) Linking ISSN: 10603271 NLM ISO Abbreviation: J AOAC Int Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : Oxford : Oxford University Press Original Publication: Arlington, VA : AOAC International, c1992- |
| مواضيع طبية MeSH: | Anti-Bacterial Agents*/analysis , Fluoroquinolones*, Excipients ; Reproducibility of Results ; Spectrophotometry ; Spectrophotometry, Ultraviolet/methods ; Tablets/analysis |
| مستخلص: | Background: Marbofloxacin (MAR) is an antimicrobial for veterinary use, and it does not have a monograph in an official compendium for the pharmaceutical form in tablets. Objective: In this context, the objective of this work was to develop and validate an effective, eco-friendly, and indicative of stability method by spectrophotometry in the ultraviolet region (UV) for quantitative evaluation of MAR in tablets. Method: Purified water-ethanol (80:20, v/v) as a diluent, quartz cubette and 296 nm were used. Results: The method was linear in the range of 3-9 µg/mL (0.9994) with detection and quantification limits of 0.39 and 1.18 µg/mL, respectively, selective in the comparison of standard and sample, precise in intraday (RSD 1.20%), interday (RSD 1.68%), and between analysts (RSD 3.26%) levels, exact with average recovery of 100.39% and robust against small changes in wavelength, diluent concentration, and the use of the ultrasound device. The forced degradation test (sample solutions prepared in 0.1 M HCl, 0.1 M NaOH, and neutral conditions and kept at 60°C during 2 h, and exposure to UV 254 nm lamp at ambient temperature during 2 h) showed that the proposed method is able to assess the susceptibility of MAR. Conclusions: The method can be reliably applied in routine analysis of MAR in tablets as well as being stable, eco-friendly, effective, accessible, and following the principles of green analytical chemistry. Highlights: MAR, an antimicrobial for veterinary use, does not have a monograph in an official compendium for final product evaluation. The use of MAR-based products with inadequate quality can leave residues in foods of animal origin and can also contribute to microbial resistance. So, an ecologically correct and reliable method was developed to evaluate MAR in a final product. (© The Author(s) 2022. Published by Oxford University Press on behalf of AOAC INTERNATIONAL. All rights reserved. For permissions, please email: journals.permissions@oup.com.) |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Excipients) 0 (Fluoroquinolones) 0 (Tablets) 8X09WU898T (marbofloxacin) |
| تواريخ الأحداث: | Date Created: 20220211 Date Completed: 20220704 Latest Revision: 20220705 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1093/jaoacint/qsac017 |
| PMID: | 35148395 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1944-7922 |
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| DOI: | 10.1093/jaoacint/qsac017 |