دورية أكاديمية
أعرض في EDS

Small Molecules Targeting PTPσ-Trk Interactions Promote Sympathetic Nerve Regeneration.

التفاصيل البيبلوغرافية
العنوان: Small Molecules Targeting PTPσ-Trk Interactions Promote Sympathetic Nerve Regeneration.
المؤلفون: Blake MR; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon 97239, United States.; Graduate Program in Biomedical Sciences, Oregon Health and Science University, Portland, Oregon 97239, United States., Gardner RT; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon 97239, United States., Jin H; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon 97239, United States., Staffenson MA; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon 97239, United States., Rueb NJ; Department of Medicinal Chemistry, University of Utah College of Pharmacy, Salt Lake City, Utah 84112, United States., Barrios AM; Department of Medicinal Chemistry, University of Utah College of Pharmacy, Salt Lake City, Utah 84112, United States., Dudley GB; C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506, United States., Cohen MS; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon 97239, United States., Habecker BA; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon 97239, United States.
المصدر: ACS chemical neuroscience [ACS Chem Neurosci] 2022 Mar 02; Vol. 13 (5), pp. 688-699. Date of Electronic Publication: 2022 Feb 14.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, D.C. : American Chemical Society
مواضيع طبية MeSH: Receptor-Like Protein Tyrosine Phosphatases, Class 2*/metabolism , Spinal Cord Injuries*/metabolism, Chondroitin Sulfate Proteoglycans/metabolism ; Humans ; Nerve Regeneration/physiology ; Phosphoric Monoester Hydrolases
مستخلص: Chondroitin sulfate proteoglycans (CSPGs) prevent sympathetic nerve regeneration in the heart after myocardial infarction and prevent central nerve regrowth after traumatic brain injury and spinal cord injury. Currently, there are no small-molecule therapeutics to promote nerve regeneration through CSPG-containing scars. CSPGs bind to monomers of receptor protein tyrosine phosphatase sigma (PTPσ) on the surface of neurons, enhancing the ability of PTPσ to bind and dephosphorylate tropomyosin receptor kinases (Trks), inhibiting their activity and preventing axon outgrowth. Targeting PTPσ-Trk interactions is thus a potential therapeutic target. Here, we describe the development and synthesis of small molecules (HJ-01 and HJ-02) that disrupt PTPσ interactions with Trks, enhance Trk signaling, and promote sympathetic nerve regeneration over CSPGs.
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معلومات مُعتمدة: R01 GM135295 United States GM NIGMS NIH HHS; T32 HL094294 United States HL NHLBI NIH HHS; F31 HL152490 United States HL NHLBI NIH HHS; R01 HL093056 United States HL NHLBI NIH HHS; P20 GM103434 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: acrylamide; chondroitin sulfate proteoglycan; nerve regeneration; protein tyrosine phosphatase receptor sigma
المشرفين على المادة: 0 (Chondroitin Sulfate Proteoglycans)
EC 3.1.3.2 (Phosphoric Monoester Hydrolases)
EC 3.1.3.48 (Receptor-Like Protein Tyrosine Phosphatases, Class 2)
تواريخ الأحداث: Date Created: 20220214 Date Completed: 20220304 Latest Revision: 20240607
رمز التحديث: 20240607
مُعرف محوري في PubMed: PMC9112862
DOI: 10.1021/acschemneuro.1c00854
PMID: 35156811
قاعدة البيانات: MEDLINE
الوصف
تدمد:1948-7193
DOI:10.1021/acschemneuro.1c00854