دورية أكاديمية
أعرض في EDS

Risk factors for readmission among patients receiving outpatient parenteral antimicrobial therapy: a retrospective cohort study.

التفاصيل البيبلوغرافية
العنوان: Risk factors for readmission among patients receiving outpatient parenteral antimicrobial therapy: a retrospective cohort study.
المؤلفون: Douiyeb S; Department of Internal Medicine, Division of Infectious Diseases, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands. s.douiyeb@amsterdamumc.nl., de la Court JR; Department of Internal Medicine, Division of Infectious Diseases, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands.; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Center, Amsterdam, The Netherlands., Tuinte B; Department of Internal Medicine, Division of Infectious Diseases, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands., Sombogaard F; Department of Clinical Pharmacology and Pharmacy, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands., Schade RP; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Center, Amsterdam, The Netherlands., Kuijvenhoven M; Department of Clinical Pharmacology and Pharmacy, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands., Minderhoud T; Department of Internal Medicine, Division of Infectious Diseases, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands., Sigaloff KCE; Department of Internal Medicine, Division of Infectious Diseases, Amsterdam UMC - Location VUmc, Amsterdam, The Netherlands.
المصدر: International journal of clinical pharmacy [Int J Clin Pharm] 2022 Apr; Vol. 44 (2), pp. 557-563. Date of Electronic Publication: 2022 Feb 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Netherlands NLM ID: 101554912 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2210-7711 (Electronic) NLM ISO Abbreviation: Int J Clin Pharm Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Dordrecht : Springer
مواضيع طبية MeSH: Anti-Infective Agents*/adverse effects , Anti-Infective Agents*/therapeutic use , Patient Readmission*, Ambulatory Care/methods ; Aminoglycosides ; Anti-Bacterial Agents/adverse effects ; Humans ; Infusions, Parenteral ; Outpatients ; Retrospective Studies ; Risk Factors ; Vancomycin/adverse effects
مستخلص: Background In the Netherlands, home treatment with intravenous antimicrobial therapy is a relatively new concept. Although several studies have shown that outpatient parenteral antimicrobial therapy (OPAT) can be administered safely, people receiving antimicrobials at home remain at risk for adverse events, including readmission. Aim The aim of our retrospective study was to identify risk factors for readmission in patients discharged with OPAT. Method Patients who were at least 18 years or older, discharged with OPAT between January 2016-December 2018 were included. Variables that were collected consisted of baseline demographics, complications, readmission within 30 days and treatment failure. Multivariate logistic regression analysis was performed to identify risk factors for readmission. Results A total of 247 patients were included; the most common reason for OPAT was bone and joint infections (17%). Penicillin (37%), cephalosporin (26%) and vancomycin/aminoglycoside (15%) were the most commonly prescribed antimicrobials. Among patients receiving medication subject to therapeutic drug monitoring (i.e. aminoglycosides or vancomycin), 51% (19/37) received weekly therapeutic drug monitoring. Receiving aminoglycosides or vancomycin (adjusted OR 2.05; 95% CI 1.30-3.25, p < 0.05) and infection of prosthetic material (adjusted OR 2.92, 95% CI 1.11-7.65, p < 0.05) were independent risk factors associated with readmission. Conclusion Although patients receiving medication subject to therapeutic drug monitoring are at higher risk of readmission, only half of the patients discharged with aminoglycosides or vancomycin were monitored according to IDSA guidelines. A specialized team in charge of monitoring patients with OPAT is more likely to increase the rate of monitoring to prevent readmissions and complications.
(© 2022. The Author(s).)
التعليقات: Erratum in: Int J Clin Pharm. 2022 Jun;44(3):834. (PMID: 35445999)
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فهرسة مساهمة: Keywords: Antimicrobial stewardship; Antimicrobial therapy; Clinical pharmacology; Outpatient parenteral antimicrobial therapy
المشرفين على المادة: 0 (Aminoglycosides)
0 (Anti-Bacterial Agents)
0 (Anti-Infective Agents)
6Q205EH1VU (Vancomycin)
تواريخ الأحداث: Date Created: 20220214 Date Completed: 20220415 Latest Revision: 20220531
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9007809
DOI: 10.1007/s11096-022-01379-7
PMID: 35157228
قاعدة البيانات: MEDLINE
الوصف
تدمد:2210-7711
DOI:10.1007/s11096-022-01379-7