دورية أكاديمية
أعرض في EDS

Effects of Catha Edulis Forsk on spatial learning, memory and correlation with serum electrolytes in wild-type male white albino rats.

التفاصيل البيبلوغرافية
العنوان: Effects of Catha Edulis Forsk on spatial learning, memory and correlation with serum electrolytes in wild-type male white albino rats.
المؤلفون: Limenie AA; Department of Physiology, Addis Ababa University, College of Health Sciences, Addis Ababa, Ethiopia., Dugul TT; Department of Physiology, Addis Ababa University, College of Health Sciences, Addis Ababa, Ethiopia., Eshetu EM; Department of Pharmacology, Addis Ababa University, College of Health Sciences, Addis Ababa, Ethiopia.
المصدر: PloS one [PLoS One] 2022 Feb 14; Vol. 17 (2), pp. e0257932. Date of Electronic Publication: 2022 Feb 14 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Catha/*chemistry , Electrolytes/*blood , Plant Extracts/*pharmacology , Spatial Learning/*drug effects, Animals ; Catha/metabolism ; Dose-Response Relationship, Drug ; Male ; Plant Extracts/chemistry ; Rats ; Swimming/physiology
مستخلص: Background: The burdens of psychostimulant use disorders are becoming a worldwide problem. One of the psychostimulants widely consumed in Ethiopia and East African countries is Catha edulis Forsk (khat). However, no studies have been conducted on the cognitive effects of khat and its correlation with serum electrolytes. The present study was aimed to evaluate the effects of khat on spatial learning and memory and their correlation with serum electrolytes.
Materials and Methods: Diethyl ether and chloroform (3:1v/v ratio) were solvents used to obtain the crude khat extract in this study. T80W was used to prepare the khat juice, fresh khat leave extract. The rats were received crude khat extract subchronically (KESC) (100 mg/kg, 200 mg/kg and 300 mg/kg b.w), khat juice (KHJ 2.5 mL/kg), 2% tween 80 in distilled water (T80W- v/v, vehicle) and khat extract subacutely (KESA) (300 mg/kg). For subchronic treatment, each rat was administered for twelve weeks before Morris water maze experiment has been started, while it was administered for a week for acute treatment. Spatial learning and memory were measured using the Morris water maze model and serum sodium, calcium, potassium, and chloride were evaluated using Cobas 6000.
Results: Spatial learning was improved with trials across the groups, while average escape latency (s) of rats received KESC 200 mg/kg (p<0.001), KESC 300 mg/kg (p<0.01) and KHJ 2.5 mL/kg (p<0.05) was significantly greater than rats that received vehicle. There was no significant difference in the latency between rats that received KESA 300mg/kg and vehicle (p>0.05). Thigmotaxis was significantly higher in rats that received all doses of khat extract (p<0.001). The time spent in the target quadrant in rats that received KESC 300 mg/kg was significantly reduced (p<0.05). Serum calcium level was inversely correlated with the escape latency (R = -0.417, p<0.05) in rats that received khat.
Conclusions: Khat extract and juice administered subchronically, but not subacutely, impaired learning and memory and was associated with serum calcium reduction. The neuronal basis for such alteration should be investigated.
Competing Interests: no competing interest.
References: Expert Opin Drug Saf. 2005 Nov;4(6):1145-54. (PMID: 16255671)
J Am Geriatr Soc. 2006 Feb;54(2):345-53. (PMID: 16460390)
J Physiol Pharmacol. 2014 Apr;65(2):241-6. (PMID: 24781733)
BMC Public Health. 2014 Nov 21;14:1198. (PMID: 25416647)
Learn Mem. 2017 Sep 15;24(10):532-542. (PMID: 28916628)
J Ethnopharmacol. 2014 Oct 28;156:102-6. (PMID: 25153022)
J Family Community Med. 2008 Jan;15(1):3-11. (PMID: 23012161)
Pharmacol Ther. 1990;48(3):397-416. (PMID: 1982180)
Iran J Basic Med Sci. 2016 Nov;19(11):1151-1158. (PMID: 27917269)
PLoS One. 2015 May 26;10(5):e0127574. (PMID: 26010883)
Clin Calcium. 2015 Feb;25(2):189-94. (PMID: 25634043)
Psychopharmacology (Berl). 2009 Jan;202(1-3):197-206. (PMID: 18478205)
Health Aff (Millwood). 2016 Jun 1;35(6):1114-20. (PMID: 27269030)
Dement Geriatr Cogn Dis Extra. 2018 Apr 24;8(1):151-157. (PMID: 29805381)
Neuroreport. 2000 Nov 9;11(16):3461-5. (PMID: 11095500)
Behav Brain Res. 2008 Dec 16;195(1):192-7. (PMID: 18588917)
BMC Complement Altern Med. 2014 Feb 20;14:66. (PMID: 24555719)
Br J Pharmacol. 1971 Feb;41(2):198-212. (PMID: 5572273)
Neurosci Lett. 2007 Oct 29;427(1):66-70. (PMID: 17920769)
J Am Soc Nephrol. 2016 Mar;27(3):766-80. (PMID: 26376860)
Saudi Med J. 2002 Jul;23(7):850-3. (PMID: 12174239)
PLoS One. 2011;6(6):e20602. (PMID: 21698275)
Indian J Physiol Pharmacol. 2014 Jul-Sep;58(3):240-50. (PMID: 25906607)
BMC Complement Altern Med. 2017 May 4;17(1):248. (PMID: 28472941)
Physiol Res. 2013;62(Suppl 1):S89-98. (PMID: 24329708)
Addict Health. 2011 Summer-Autumn;3(3-4):137-49. (PMID: 24494129)
Nephrol Dial Transplant. 2013 Sep;28(9):2206-9. (PMID: 23804804)
Neurobiol Learn Mem. 2008 Feb;89(2):185-91. (PMID: 17904876)
BMC Geriatr. 2021 May 24;21(1):328. (PMID: 34030649)
Afr Health Sci. 2017 Mar;17(1):175-185. (PMID: 29026391)
Pharmacogn Mag. 2017 Jul;13(Suppl 2):S354-S358. (PMID: 28808405)
PLoS One. 2016 Jun 08;11(6):e0155457. (PMID: 27275601)
Adv Nutr. 2014 Nov 14;5(6):712-41. (PMID: 25398734)
Ann Thorac Med. 2017 Oct-Dec;12(4):247-251. (PMID: 29118856)
Int J Neurosci. 2004 May;114(5):683-99. (PMID: 15204074)
Metab Brain Dis. 2016 Feb;31(1):45-52. (PMID: 26423676)
Nutr Res Pract. 2012 Dec;6(6):527-33. (PMID: 23346303)
Arch Clin Neuropsychol. 2002 Jan;17(1):57-67. (PMID: 14589753)
Evid Based Complement Alternat Med. 2012;2012:829401. (PMID: 23259000)
J Neurosci. 2009 Aug 12;29(32):10111-9. (PMID: 19675245)
Front Behav Neurosci. 2009 Jan 15;2:5. (PMID: 19169362)
J Am Heart Assoc. 2017 Jan 11;6(1):. (PMID: 28077386)
المشرفين على المادة: 0 (Electrolytes)
0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20220214 Date Completed: 20220301 Latest Revision: 20220301
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8843189
DOI: 10.1371/journal.pone.0257932
PMID: 35157725
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0257932