دورية أكاديمية
أعرض في EDS

Rare Occurrence of Aristolochic Acid Mutational Signatures in Oro-Gastrointestinal Tract Cancers.

التفاصيل البيبلوغرافية
العنوان: Rare Occurrence of Aristolochic Acid Mutational Signatures in Oro-Gastrointestinal Tract Cancers.
المؤلفون: Lim AH; Cheng Kin Ku Herbal Biodiversity & Medicine Program, SingHealth Duke-NUS Institute of Biodiversity Medicine, Singapore 169610, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore 169610, Singapore.; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore 169610, Singapore., Chan JY; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore 169610, Singapore.; Division of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore., Yu MC; Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan 333, Taiwan.; Department of Surgery, New Taipei Municipal Tucheng Hospital, New Taipei City 236, Taiwan.; College of Medicine, Chang Gung University, Taoyuan 333, Taiwan., Wu TH; Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan 333, Taiwan., Hong JH; Cheng Kin Ku Herbal Biodiversity & Medicine Program, SingHealth Duke-NUS Institute of Biodiversity Medicine, Singapore 169610, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore 169857, Singapore., Ng CCY; Cheng Kin Ku Herbal Biodiversity & Medicine Program, SingHealth Duke-NUS Institute of Biodiversity Medicine, Singapore 169610, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore 169610, Singapore.; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore 169610, Singapore., Low ZJ; Cheng Kin Ku Herbal Biodiversity & Medicine Program, SingHealth Duke-NUS Institute of Biodiversity Medicine, Singapore 169610, Singapore., Liu W; Cheng Kin Ku Herbal Biodiversity & Medicine Program, SingHealth Duke-NUS Institute of Biodiversity Medicine, Singapore 169610, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore 169610, Singapore.; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore 169610, Singapore., Vikneswari R; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore 169610, Singapore.; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore 169610, Singapore., Sung PC; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taoyuan 333, Taiwan., Fan WL; Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taoyuan 333, Taiwan., Teh BT; Cheng Kin Ku Herbal Biodiversity & Medicine Program, SingHealth Duke-NUS Institute of Biodiversity Medicine, Singapore 169610, Singapore.; Cancer Discovery Hub, National Cancer Centre Singapore, Singapore 169610, Singapore.; Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore 169610, Singapore.; Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore 169857, Singapore., Hsieh SY; College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.; Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taoyuan 333, Taiwan.
المصدر: Cancers [Cancers (Basel)] 2022 Jan 24; Vol. 14 (3). Date of Electronic Publication: 2022 Jan 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: Background: Aristolochic acids (AAs) are potent mutagens commonly found in herbal plant-based remedies widely used throughout Asian countries.
Patients and Methods: To understand whether AA is involved in the tumorigenesis of the oro-gastrointestinal tract, we used whole-exome sequencing to profile 54 cases of four distinct types of oro-gastrointestinal tract cancer (OGITC) from Taiwan.
Results: A diverse landscape of mutational signatures including those from DNA mismatch repair and reactive oxygen species was observed. APOBEC mutational signatures were observed in 60% of oral squamous cell carcinomas. Only one sample harbored AA mutational signatures, contradictory to prior reports of cancers from Taiwan. The metabolism of AA in the liver and urinary tract, transient exposure time, and high cell turnover rates at OGITC sites may explain our findings.
Conclusion: AA signatures in OGITCs are rare and unlikely to be a major contributing factor in oro-gastrointestinal tract tumorigenesis.
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معلومات مُعتمدة: CORPG3J0131-2 Chang Gung Memorial Hospital; MOH-STAR18NOV-0001 National Medical Research Council; MOH-OFIRG18may-0011 National Medical Research Council; CORPG3J0151-2 Chang Gung Memorial Hospital
فهرسة مساهمة: Keywords: aristolochic acid; carcinogens; genomics; mutagenesis; next generation sequencing
تواريخ الأحداث: Date Created: 20220215 Latest Revision: 20220219
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8833562
DOI: 10.3390/cancers14030576
PMID: 35158844
قاعدة البيانات: MEDLINE
الوصف
تدمد:2072-6694
DOI:10.3390/cancers14030576