دورية أكاديمية
أعرض في EDS

Low Energy Status under Methionine Restriction Is Essentially Independent of Proliferation or Cell Contact Inhibition.

التفاصيل البيبلوغرافية
العنوان: Low Energy Status under Methionine Restriction Is Essentially Independent of Proliferation or Cell Contact Inhibition.
المؤلفون: Koderer C; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany., Schmitz W; Department of Biochemistry and Molecular Biology, Biocenter, D-97074 Wuerzburg, Germany., Wünsch AC; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany., Balint J; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany., El-Mesery M; Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt., Volland JM; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany., Hartmann S; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany., Linz C; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany., Kübler AC; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany., Seher A; Department of Oral and Maxillofacial Plastic Surgery, University Hospital Wuerzburg, D-97070 Wuerzburg, Germany.
المصدر: Cells [Cells] 2022 Feb 04; Vol. 11 (3). Date of Electronic Publication: 2022 Feb 04.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Methionine*/metabolism , Neoplasms*, Adenosine Triphosphate ; Amino Acids ; Animals ; Cell Proliferation ; Contact Inhibition ; Mice
مستخلص: Nonlimited proliferation is one of the most striking features of neoplastic cells. The basis of cell division is the sufficient presence of mass (amino acids) and energy (ATP and NADH). A sophisticated intracellular network permanently measures the mass and energy levels. Thus, in vivo restrictions in the form of amino acid, protein, or caloric restrictions strongly affect absolute lifespan and age-associated diseases such as cancer. The induction of permanent low energy metabolism (LEM) is essential in this process. The murine cell line L929 responds to methionine restriction (MetR) for a short time period with LEM at the metabolic level defined by a characteristic fingerprint consisting of the molecules acetoacetate, creatine, spermidine, GSSG, UDP-glucose, pantothenate, and ATP. Here, we used mass spectrometry (LC/MS) to investigate the influence of proliferation and contact inhibition on the energy status of cells. Interestingly, the energy status was essentially independent of proliferation or contact inhibition. LC/MS analyses showed that in full medium, the cells maintain active and energetic metabolism for optional proliferation. In contrast, MetR induced LEM independently of proliferation or contact inhibition. These results are important for cell behaviour under MetR and for the optional application of restrictions in cancer therapy.
References: Cell Metab. 2016 Apr 12;23(4):580-9. (PMID: 27076075)
Semin Cell Dev Biol. 2020 Feb;98:34-43. (PMID: 31100352)
Cell. 2011 Mar 4;144(5):646-74. (PMID: 21376230)
Exp Gerontol. 2013 Jul;48(7):647-53. (PMID: 23470275)
Cell. 2006 Jul 28;126(2):257-68. (PMID: 16873059)
Nat Med. 2018 Feb;24(2):194-202. (PMID: 29334372)
Oncol Rep. 2018 Jun;39(6):2845-2854. (PMID: 29693131)
CA Cancer J Clin. 2006 Nov-Dec;56(6):323-53. (PMID: 17135691)
Trends Endocrinol Metab. 2014 Nov;25(11):558-66. (PMID: 25153840)
Nutrients. 2016 Jul 20;8(7):. (PMID: 27447667)
Oncogene. 2011 Jul 28;30(30):3305-16. (PMID: 21516129)
J Exp Biol. 2005 May;208(Pt 9):1717-30. (PMID: 15855403)
Exp Gerontol. 2013 Oct;48(10):1120-8. (PMID: 23454633)
Int J Mol Sci. 2021 Mar 16;22(6):. (PMID: 33809777)
Nutrients. 2019 Sep 12;11(9):. (PMID: 31547425)
FEBS Lett. 2020 Jun 21;:. (PMID: 32564372)
Methods Mol Biol. 2019;1866:49-60. (PMID: 30725407)
EMBO J. 2018 Jul 13;37(14):. (PMID: 29875130)
Nat Cell Biol. 2019 Jan;21(1):63-71. (PMID: 30602761)
Nutrients. 2020 Mar 03;12(3):. (PMID: 32138282)
Blood. 2019 Sep 26;134(13):1014-1023. (PMID: 31416801)
Ann N Y Acad Sci. 2016 Jan;1363:68-79. (PMID: 26916321)
Science. 2009 May 22;324(5930):1029-33. (PMID: 19460998)
Oncogene. 2018 Aug;37(35):4769-4780. (PMID: 29780167)
Cell Metab. 2019 Mar 5;29(3):592-610. (PMID: 30840912)
J Clin Invest. 2013 Sep;123(9):3678-84. (PMID: 23999442)
Front Genet. 2016 Aug 18;7:142. (PMID: 27588026)
Gerontology. 2017;63(4):327-336. (PMID: 28118636)
Science. 2017 Nov 10;358(6364):813-818. (PMID: 29123071)
Cell Metab. 2014 Mar 4;19(3):407-17. (PMID: 24606898)
Dev Cell. 2016 Mar 7;36(5):540-9. (PMID: 26954548)
Cancer Treat Rev. 2012 Oct;38(6):726-36. (PMID: 22342103)
Am J Physiol. 1947 Sep;150(3):511-9. (PMID: 20265851)
Prog Biophys Mol Biol. 2018 May;134:55-67. (PMID: 29307754)
Metabolites. 2021 Jan 31;11(2):. (PMID: 33572567)
Exp Cell Res. 2017 Oct 1;359(1):17-19. (PMID: 28642051)
J Clin Invest. 2015 Jan;125(1):85-93. (PMID: 25654554)
Aging Cell. 2019 Feb;18(1):e12876. (PMID: 30430746)
Curr Opin Cell Biol. 2012 Oct;24(5):685-94. (PMID: 22835462)
Int J Mol Sci. 2018 Oct 19;19(10):. (PMID: 30347687)
Nat Rev Cancer. 2018 Nov;18(11):707-719. (PMID: 30327499)
Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2169-74. (PMID: 23345430)
فهرسة مساهمة: Keywords: L929; LC/MS; amino acid; caloric restriction; contact inhibition; liquid chromatography/mass spectrometry; mass spectrometry; metabolomics; methionine restriction; proliferation
المشرفين على المادة: 0 (Amino Acids)
8L70Q75FXE (Adenosine Triphosphate)
AE28F7PNPL (Methionine)
تواريخ الأحداث: Date Created: 20220215 Date Completed: 20220408 Latest Revision: 20220408
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8833905
DOI: 10.3390/cells11030551
PMID: 35159360
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4409
DOI:10.3390/cells11030551