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Antidiabetic Activity and In Silico Molecular Docking of Polyphenols from Ammannia baccifera L. subsp. Aegyptiaca (Willd.) Koehne Waste: Structure Elucidation of Undescribed Acylated Flavonol Diglucoside.

التفاصيل البيبلوغرافية
العنوان: Antidiabetic Activity and In Silico Molecular Docking of Polyphenols from Ammannia baccifera L. subsp. Aegyptiaca (Willd.) Koehne Waste: Structure Elucidation of Undescribed Acylated Flavonol Diglucoside.
المؤلفون: Swilam N; Department of Pharmacognosy, Faculty of Pharmacy, The British University in Egypt (BUE), El Sherouk City 11837, Egypt., Nawwar MAM; National Research Centre, Department of Phytochemistry and Plant Systematic, Dokki 12622, Egypt., Radwan RA; Department of Biochemistry, Faculty of Pharmacy, Sinai University-Kantara Branch, El Ismailia 41611, Egypt., Mostafa ES; Department of Pharmacognosy, Faculty of Pharmacy, October University of Modern Sciences and Arts (MSA University), Giza 11787, Egypt.
المصدر: Plants (Basel, Switzerland) [Plants (Basel)] 2022 Feb 06; Vol. 11 (3). Date of Electronic Publication: 2022 Feb 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596181 Publication Model: Electronic Cited Medium: Print ISSN: 2223-7747 (Print) Linking ISSN: 22237747 NLM ISO Abbreviation: Plants (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2012]-
مستخلص: Chemical investigation of the aerial parts of Ammania aegyptiaca ethanol extract (AEEE) showed high concentrations of polyphenol and flavonoid content, with notable antioxidant activity. Undescribed acylated diglucoside flavonol myricetin 3- O - β - 4 C 1 -(6″- O -galloyl glucopyranoside) 7- O - β - 4 C 1 -glucopyranoside (MGGG) was isolated from the aerial parts of AEEE, along with four known polyphenols that had not been characterized previously from AEEE. The inhibitory effects of MGGG, AEEE, and all compounds against α -amylase, pancreatic lipase and β -glucosidase were assessed. In addition, molecular docking was used to determine the inhibition of digestive enzymes, and this confirmed that the MGGG interacted strongly with the active site residues of these enzymes, with the highest binding free energy against α -amylase (-8.99 kcal/mol), as compared to the commercial drug acarbose (-5.04 kcal/mol), thus justifying its use in the potential management of diabetes. In streptozotocin (STZ)-induced diabetic rats, AEEE significantly decreased high serum glucose, α -amylase activity and serum liver and kidney function markers, as well as increasing insulin blood level. Moreover, AEEE improved the lipid profile of diabetic animals, increased superoxide dismutase (SOD) activity, and inhibited lipid peroxidation. Histopathological studies proved the decrease in pancreas damage and supported the biochemical findings. These results provide evidence that AEEE and MGGG possess potent antidiabetic activity, which warrants additional investigation.
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فهرسة مساهمة: Keywords: Ammania aegyptiaca; diabetes; digestive enzymes; molecular docking; myricetin 3-O-β-4C1-(6″-O-galloylglucopyranoside) 7-O-β-4C1-glucopyranoside
تواريخ الأحداث: Date Created: 20220215 Latest Revision: 20220219
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8840488
DOI: 10.3390/plants11030452
PMID: 35161433
قاعدة البيانات: MEDLINE
الوصف
تدمد:2223-7747
DOI:10.3390/plants11030452