دورية أكاديمية
أعرض في EDS

The value of clinical-ultrasonographic feature model to predict the severity of secondary hyperparathyroidism.

التفاصيل البيبلوغرافية
العنوان: The value of clinical-ultrasonographic feature model to predict the severity of secondary hyperparathyroidism.
المؤلفون: Zhang X; Department of Medical Ultrasonics, The First Affiliated Hospital, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Guangzhou, China., Xu W; Department of Medical Ultrasonics, The First Affiliated Hospital, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Guangzhou, China., Huang T; Department of Medical Ultrasonics, The First Affiliated Hospital, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Guangzhou, China., Huang J; Department of Medical Ultrasonics, The First Affiliated Hospital, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Guangzhou, China., Zhang C; Department of Medical Ultrasonics, The First Affiliated Hospital, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Guangzhou, China., Zhang Y; Department of Medical Ultrasonics, The First Affiliated Hospital, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Guangzhou, China., Xie X; Department of Medical Ultrasonics, The First Affiliated Hospital, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Guangzhou, China., Xu M; Department of Medical Ultrasonics, The First Affiliated Hospital, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Guangzhou, China.
المصدر: Renal failure [Ren Fail] 2022 Dec; Vol. 44 (1), pp. 146-154.
نوع المنشور: Journal Article; Observational Study
اللغة: English
بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Informa Healthcare
Original Publication: New York, N.Y. : M. Dekker, c1987-
مواضيع طبية MeSH: Hyperparathyroidism, Secondary/*diagnostic imaging , Kidney Failure, Chronic/*complications , Parathyroid Glands/*diagnostic imaging , Renal Dialysis/*adverse effects , Ultrasonography, Doppler, Color/*methods, Adult ; Aged ; Calcium/blood ; Female ; Humans ; Hyperparathyroidism, Secondary/blood ; Hyperparathyroidism, Secondary/etiology ; Hyperparathyroidism, Secondary/surgery ; Kidney Failure, Chronic/metabolism ; Kidney Failure, Chronic/therapy ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Nomograms ; Parathyroid Glands/blood supply ; Parathyroid Glands/pathology ; Parathyroid Hormone/blood ; Parathyroidectomy ; Phosphorus/blood ; Retrospective Studies ; Treatment Outcome
مستخلص: Objectives: To analyze conventional ultrasound (CUS) and contrast-enhanced ultrasound (CEUS) features in patients with secondary hyperparathyroidism (SHPT) and to evaluate the clinical-ultrasonographic feature based model for predicting the severity of SHPT.
Methods: From February 2016 to March 2021, a total of 59 patients (age 51.3 ± 11.7 years, seCr 797.8 ± 431.7 μmol/L, iPTH 1535.1 ± 1063.9 ng/L) with SHPT (including 181 parathyroid glands (PTGs)) without the history of intact parathyroid hormone (iPTH)-reducing drugs using were enrolled. The patients were divided into the mild SHPT group (mSHPT, iPTH <800 ng/L) and the severe SHPT group (sSHPT, iPTH ≥ 800 ng/L) according to the serum iPTH level. The clinical test data of patients were collected and CUS and CEUS examinations were performed for every patient. Multivariable logistic regression model according to clinical-ultrasonographic features was adopted to establish a nomogram. We performed K-fold cross-validation on this nomogram model and nomogram performance was determined by its discrimination, calibration, and clinical usefulness.
Results: There were 19 patients in the mSHPT group and 40 patients in the sSHPT group. Multivariable logistic regression indicated serum calcium, serum phosphorus and total volume of PTGs were independent predictors related with serum iPTH level. Even though CEUS score of wash-in and wash-out were showed related to severity of SHPT in univariate logistic regression analysis, they were not predictors of SHPT severity ( p  = 0.539, 0.474 respectively). The nomogram developed by clinical and ultrasonographic features showed good calibration and discrimination. The accuracy and the area under the curve (AUC), positive predictive value (PPV), negative predictive value (NPV) and accuracy of this model were 0.888, 92.5%, 63.2% and 83.1%, respectively. When applied to internal validation, the score revealed good discrimination with stratified fivefold cross-validation in the cohort (mean AUC = 0.833).
Conclusions: The clinical-ultrasonographic features model has good performance for predicting the severity of SHPT.
References: Atherosclerosis. 2018 Nov;278:49-59. (PMID: 30253289)
Ren Fail. 2021 Dec;43(1):445-451. (PMID: 33663332)
J Clin Lab Anal. 2019 Mar;33(3):e22696. (PMID: 30485538)
Calcif Tissue Int. 2021 Apr;108(4):486-495. (PMID: 33386480)
Diagn Interv Imaging. 2016 Feb;97(2):219-25. (PMID: 26432401)
J Nephrol. 2013 Sep-Oct;26(5):848-55. (PMID: 23042437)
Kidney Int. 1996 Nov;50(5):1663-71. (PMID: 8914034)
Am J Surg. 1992 Jul;164(1):51-6. (PMID: 1626607)
J Am Soc Nephrol. 2000 Jun;11(6):1141-1152. (PMID: 10820180)
Semin Dial. 2019 Sep;32(5):444-451. (PMID: 30656752)
J Bone Miner Res. 1999 Nov;14(11):1848-54. (PMID: 10571684)
Radiol Med. 1993 May;85(5 Suppl 1):114-9. (PMID: 8332786)
Kidney Int. 1998 Dec;54(6):2140-5. (PMID: 9853280)
Clin Hemorheol Microcirc. 2020;75(1):35-46. (PMID: 31868660)
Am J Kidney Dis. 1997 Jun;29(6):862-5. (PMID: 9186071)
Semin Dial. 2019 Nov;32(6):541-552. (PMID: 31313380)
Am J Nephrol. 2008;28(4):589-97. (PMID: 18277066)
Clin Exp Nephrol. 2017 Mar;21(Suppl 1):37-45. (PMID: 28044233)
Kidney Int. 2010 Nov;78(10):975-80. (PMID: 20844473)
PLoS One. 2016 Jan 25;11(1):e0146801. (PMID: 26808154)
Ultraschall Med. 2011 Jan;32 Suppl 1:S74-82. (PMID: 20414855)
J Clin Endocrinol Metab. 1998 Aug;83(8):2765-72. (PMID: 9709944)
Ther Apher Dial. 2006 Apr;10(2):198-204. (PMID: 16684224)
Clin J Am Soc Nephrol. 2018 Jun 7;13(6):952-961. (PMID: 29523679)
Kidney Int Suppl (2011). 2017 Jul;7(1):1-59. (PMID: 30675420)
J Am Soc Nephrol. 2005 Jul;16(7):2190-7. (PMID: 15888568)
Ther Apher Dial. 2008 Oct;12(5):391-5. (PMID: 18937723)
Ultrasound Med Biol. 1990;16(6):553-9. (PMID: 2238263)
Sci Rep. 2019 Oct 10;9(1):14634. (PMID: 31602011)
Radiol Med. 2013 Aug;118(5):707-22. (PMID: 23090243)
Drugs. 2016 May;76(8):841-52. (PMID: 27142279)
Kidney Int. 2015 Aug;88(2):350-9. (PMID: 25786097)
Pediatr Nephrol. 2020 Mar;35(3):493-500. (PMID: 31696357)
Biomed Res Int. 2016;2016:6064526. (PMID: 28078296)
فهرسة مساهمة: Keywords: Secondary hyperparathyroidism; clinical-ultrasonographic feature; contrast-enhanced ultrasonography; intact parathyroid hormone; nomogram
المشرفين على المادة: 0 (Parathyroid Hormone)
27YLU75U4W (Phosphorus)
SY7Q814VUP (Calcium)
تواريخ الأحداث: Date Created: 20220215 Date Completed: 20220307 Latest Revision: 20220501
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8856024
DOI: 10.1080/0886022X.2022.2027784
PMID: 35164637
قاعدة البيانات: MEDLINE
الوصف
تدمد:1525-6049
DOI:10.1080/0886022X.2022.2027784