دورية أكاديمية
Pre-infection plasma cytokines and chemokines as predictors of HIV disease progression.
| العنوان: | Pre-infection plasma cytokines and chemokines as predictors of HIV disease progression. |
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| المؤلفون: | Ngcobo S; Centre for the AIDS Programme of Research in South Africa (CAPRISA), 719 Umbilo Road, Durban, South Africa.; Department of Medical Microbiology, University of KwaZulu-Natal, Durban, South Africa., Molatlhegi RP; Centre for the AIDS Programme of Research in South Africa (CAPRISA), 719 Umbilo Road, Durban, South Africa.; Department of Medical Microbiology, University of KwaZulu-Natal, Durban, South Africa., Osman F; Centre for the AIDS Programme of Research in South Africa (CAPRISA), 719 Umbilo Road, Durban, South Africa., Ngcapu S; Centre for the AIDS Programme of Research in South Africa (CAPRISA), 719 Umbilo Road, Durban, South Africa.; Department of Medical Microbiology, University of KwaZulu-Natal, Durban, South Africa., Samsunder N; Centre for the AIDS Programme of Research in South Africa (CAPRISA), 719 Umbilo Road, Durban, South Africa., Garrett NJ; Centre for the AIDS Programme of Research in South Africa (CAPRISA), 719 Umbilo Road, Durban, South Africa.; Discipline of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South Africa., Abdool Karim SS; Centre for the AIDS Programme of Research in South Africa (CAPRISA), 719 Umbilo Road, Durban, South Africa.; Department of Epidemiology, Columbia University, New York, NY, USA., Abdool Karim Q; Centre for the AIDS Programme of Research in South Africa (CAPRISA), 719 Umbilo Road, Durban, South Africa.; Department of Epidemiology, Columbia University, New York, NY, USA., McKinnon LR; Centre for the AIDS Programme of Research in South Africa (CAPRISA), 719 Umbilo Road, Durban, South Africa.; Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.; Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya., Sivro A; Centre for the AIDS Programme of Research in South Africa (CAPRISA), 719 Umbilo Road, Durban, South Africa. aida.sivro@caprisa.org.; Department of Medical Microbiology, University of KwaZulu-Natal, Durban, South Africa. aida.sivro@caprisa.org. |
| المصدر: | Scientific reports [Sci Rep] 2022 Feb 14; Vol. 12 (1), pp. 2437. Date of Electronic Publication: 2022 Feb 14. |
| نوع المنشور: | Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | Disease Progression*, Anti-HIV Agents/*therapeutic use , Chemokines/*blood , HIV Infections/*blood , HIV Infections/*prevention & control , HIV-1/*immunology , Tenofovir/*therapeutic use, Adolescent ; Adult ; Biomarkers/blood ; CD4-CD8 Ratio ; Cohort Studies ; Double-Blind Method ; Female ; HIV Infections/epidemiology ; HIV Infections/immunology ; HIV Seropositivity ; Humans ; Immunity ; Prognosis ; South Africa/epidemiology ; Treatment Outcome ; Viral Load ; Young Adult |
| مستخلص: | Previous studies have highlighted the role of pre-infection systemic inflammation on HIV acquisition risk, but the extent to which it predicts disease progression outcomes is less studied. Here we examined the relationship between pre-infection plasma cytokine expression and the rate of HIV disease progression in South African women who seroconverted during the CAPRISA 004 tenofovir gel trial. Bio-Plex 200 system was used to measure the expression of 47 cytokines/chemokines in 69 seroconvertors from the CAPRISA 004 trial. Cox proportional hazards regression analyses were used to measure associations between cytokine expression and CD4 decline prior to antiretroviral therapy initiation. Linear regression models were used to assess whether pre-infection cytokine expression were predictors of disease progression outcomes including peak and set-point viral load and CD4:CD8 ratio at less and greater than180 days post infection. Several cytokines were associated with increased peak HIV viral load (including IL-16, SCGFβ, MCP-3, IL-12p40, SCF, IFNα2 and IL-2). The strongest association with peak viral load was observed for SCGFβ, which was also inversely associated with lowest CD4:CD8 ratio < 180 days post infection and faster CD4 decline below 500 cells/µl (adjusted HR 4.537, 95% CI 1.475-13.954; p = 0.008) in multivariable analysis adjusting for age, study site, contraception, baseline HSV-2 status and trial arm allocation. Our results show that pre-infection systemic immune responses could play a role in HIV disease progression, especially in the early stages of infection. (© 2022. The Author(s).) |
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| معلومات مُعتمدة: | R21 AI115978-01 United States NH NIH HHS; Canada CIHR |
| المشرفين على المادة: | 0 (Anti-HIV Agents) 0 (Biomarkers) 0 (Chemokines) 99YXE507IL (Tenofovir) |
| تواريخ الأحداث: | Date Created: 20220215 Date Completed: 20220311 Latest Revision: 20220928 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8844050 |
| DOI: | 10.1038/s41598-022-06532-w |
| PMID: | 35165387 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2045-2322 |
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| DOI: | 10.1038/s41598-022-06532-w |